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Tbio
SPINK6
Serine protease inhibitor Kazal-type 6

Protein Summary
Description
Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8. The protein encoded by this gene is a Kazal-type serine protease inhibitor that acts on kallikrein-related peptidases in the skin. Two transcript variants the same protein have been found for this gene. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325630
  • ENSP00000324870
  • ENSG00000178172
  • ENST00000621437
  • ENSP00000481309

Symbol
  • BUSI2
  • UNQ844
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.48
cell line
0.47
biological term
0.35
drug
0.35
transcription factor
0.34


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.67   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.67   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0