Tchem SPHK1 Sphingosine kinase 1

Protein Summary

Description

Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]

Uniprot Accession IDs

• Q9NYA1
• Q8N632
• Q96GK1
• Q9HD92
• Q9NY70
• Q9NYL3
• SK 1

Gene Name

• SPHK1

Ensembl ID

• ENST00000323374
• ENSP00000313681
• ENSG00000176170
• ENST00000392496
• ENSP00000376285
• ENST00000545180
• ENSP00000440970
• ENST00000590959
• ENSP00000468547
• ENST00000592299
• ENSP00000465726

Symbol

• SPHK
• SPK
• SPHK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.99
disease	0.91
gene perturbation	0.9
histone modification site profile	0.84

Protein Classes

DTO Classes

Protein / Kinase / Non-protein Kinase / Lipid Kinase / Sphingosine Kinase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 947.97   (req: < 5)

Gene RIFs: 285   (req: <= 3)

Antibodies: 667   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 947.97   (req: >= 5)

Gene RIFs: 285   (req: > 3)

Antibodies: 667   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 45

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0