Tbio SPDYA Speedy protein A

Protein Summary

Description

Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:12972555). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation (PubMed:28666995). Mediates cell survival during the DNA damage process through activation of CDK2 (PubMed:12839962).

Uniprot Accession IDs

• Q5MJ70
• Q53R05
• Q5MJ69

Gene Name

• SPDYA

Ensembl ID

• ENST00000334056
• ENSP00000335628
• ENSG00000163806
• ENST00000379579
• ENSP00000368898

Symbol

• SPDY1
• SPY1
• SPY1
• SPDY1
• RINGO3
• RINGOA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.79
transcription factor	0.65
tissue sample	0.59
biological process	0.55
cell type or tissue	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.16   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 194   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.16   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0