| Tdark | Kinetochore protein Spc25 |
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).
This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008]
This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 2.2e-20 |
| psoriasis | 6694 | 3.2e-12 |
| Breast cancer | 3578 | 5.2e-10 |
| group 3 medulloblastoma | 4104 | 9.8e-09 |
| glioblastoma | 5792 | 1.3e-08 |
| medulloblastoma, large-cell | 6241 | 1.5e-08 |
| lung carcinoma | 2843 | 4.1e-08 |
| malignant mesothelioma | 3232 | 2.0e-07 |
| primitive neuroectodermal tumor | 3035 | 7.2e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 5.2e-06 |
| Astrocytoma, Pilocytic | 3081 | 6.2e-06 |
| lung adenocarcinoma | 2716 | 6.8e-06 |
| breast carcinoma | 1638 | 4.3e-05 |
| adult high grade glioma | 3801 | 1.2e-04 |
| Atopic dermatitis | 952 | 1.9e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.4e-04 |
| posterior fossa group A ependymoma | 468 | 9.9e-04 |
| ovarian cancer | 8520 | 1.1e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.8e-03 |
| lung cancer | 4740 | 2.5e-03 |
| ulcerative colitis | 1819 | 4.2e-03 |
| invasive ductal carcinoma | 2951 | 5.8e-03 |
| colon cancer | 1478 | 7.8e-03 |
| adrenocortical carcinoma | 1428 | 1.4e-02 |
| Endometriosis | 540 | 2.2e-02 |
| ductal carcinoma in situ | 1745 | 2.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Acquired metabolic disease | 336 | 0.0 | 3.0 |
| Metabolic syndrome X | 52 | 0.0 | 3.0 |
| Type 2 diabetes mellitus | 272 | 0.0 | 3.0 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | 1.143 | 1.4e-02 |
| adult high grade glioma | 1.900 | 1.2e-04 |
| Astrocytoma, Pilocytic | 1.200 | 6.2e-06 |
| Atopic dermatitis | 1.800 | 1.9e-04 |
| atypical teratoid / rhabdoid tumor | 2.500 | 5.2e-06 |
| Breast cancer | 1.800 | 5.2e-10 |
| breast carcinoma | 1.400 | 4.3e-05 |
| colon cancer | 3.000 | 7.8e-03 |
| ductal carcinoma in situ | 1.200 | 2.6e-02 |
| Endometriosis | 1.324 | 2.2e-02 |
| glioblastoma | 2.500 | 1.3e-08 |
| group 3 medulloblastoma | 3.400 | 9.8e-09 |
| intraductal papillary-mucinous carcinoma... | 1.600 | 1.8e-03 |
| intraductal papillary-mucinous neoplasm ... | 2.500 | 3.4e-04 |
| invasive ductal carcinoma | 1.400 | 5.8e-03 |
| lung adenocarcinoma | 1.400 | 6.8e-06 |
| lung cancer | 1.800 | 2.5e-03 |
| lung carcinoma | 1.100 | 4.1e-08 |
| malignant mesothelioma | 2.000 | 2.0e-07 |
| medulloblastoma, large-cell | 3.500 | 1.5e-08 |
| non-small cell lung cancer | 2.113 | 2.2e-20 |
| ovarian cancer | 1.400 | 1.1e-03 |
| posterior fossa group A ependymoma | 1.200 | 9.9e-04 |
| primitive neuroectodermal tumor | 3.400 | 7.2e-07 |
| psoriasis | 1.700 | 3.2e-12 |
| ulcerative colitis | 1.100 | 4.2e-03 |
