1. Home
  2. Targets
  3. Kinetochore protein Spc25

Tdark Kinetochore protein Spc25

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).

This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 12
PubMed Score 0.33
PubTator Score 18.73

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Expression

  Differential Expression (26)

Disease log2 FC p
adrenocortical carcinoma 1.143 1.4e-02
adult high grade glioma 1.900 1.2e-04
Astrocytoma, Pilocytic 1.200 6.2e-06
Atopic dermatitis 1.800 1.9e-04
atypical teratoid / rhabdoid tumor 2.500 5.2e-06
Breast cancer 1.800 5.2e-10
breast carcinoma 1.400 4.3e-05
colon cancer 3.000 7.8e-03
ductal carcinoma in situ 1.200 2.6e-02
Endometriosis 1.324 2.2e-02
glioblastoma 2.500 1.3e-08
group 3 medulloblastoma 3.400 9.8e-09
intraductal papillary-mucinous carcinoma... 1.600 1.8e-03
intraductal papillary-mucinous neoplasm ... 2.500 3.4e-04
invasive ductal carcinoma 1.400 5.8e-03
lung adenocarcinoma 1.400 6.8e-06
lung cancer 1.800 2.5e-03
lung carcinoma 1.100 4.1e-08
malignant mesothelioma 2.000 2.0e-07
medulloblastoma, large-cell 3.500 1.5e-08
non-small cell lung cancer 2.113 2.2e-20
ovarian cancer 1.400 1.1e-03
posterior fossa group A ependymoma 1.200 9.9e-04
primitive neuroectodermal tumor 3.400 7.2e-07
psoriasis 1.700 3.2e-12
ulcerative colitis 1.100 4.2e-03

Synonym

Accession Q9HBM1 A8K4X8 D3DPC0 hSpc25
Symbols AD024
SPBC25
hSpc25

Gene

SPC25

  Ortholog (10)

Species Source Disease
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA

 UniProt Keyword (12)

See all...

 GO Component (4)

 GO Process (4)

 Compartment GO Term (28)

See all...

 GWAS Trait (3)

 HCA RNA Cell Line (56)

See all...

Pathway (16)

See all...

Protein-protein Interaction (15)

SPECC1L   KNL1   EPS15   NDC80   KTN1   EPS15L1   MYO18A   CSPP1   NUF2   FCHO2   MIS12   SNAP29   ATG16L1   C12orf43   SPC24  

PDB (2)

Gene RIF (3)

AA Sequence 

MVEDELALFDKSINEFWNKFKSTDTSCQMAGLRDTYKDSIKAFAEKLSVKLKEEERMVEMFLEYQNQISR      1 - 70
QNKLIQEKKDNLLKLIAEVKGKKQELEVLTANIQDLKEEYSRKKETISTANKANAERLKRLQKSADLYKD     71 - 140
RLGLEIRKIYGEKLQFIFTNIDPKNPESPFMFSLHLNEARDYEVSDSAPHLEGLAEFQENVRKTNNFSAF    141 - 210
LANVRKAFTATVYN                                                            211 - 224
//

Text Mined References (17)

PMID Year Title