| Tdark | Kinetochore protein Spc25 |
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).
This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008]
This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count |
|---|---|
| IGA Glomerulonephritis | 454 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6685 | 6.1e-101 |
| non-small cell lung cancer | 2798 | 2.2e-20 |
| Breast cancer | 3098 | 8.4e-09 |
| group 3 medulloblastoma | 2254 | 9.8e-09 |
| medulloblastoma, large-cell | 6234 | 1.5e-08 |
| lung carcinoma | 2844 | 4.1e-08 |
| malignant mesothelioma | 3163 | 2.0e-07 |
| pediatric high grade glioma | 2712 | 3.9e-07 |
| primitive neuroectodermal tumor | 3031 | 7.2e-07 |
| atypical teratoid / rhabdoid tumor | 4369 | 5.2e-06 |
| glioblastoma | 5572 | 5.2e-06 |
| lung adenocarcinoma | 2714 | 6.8e-06 |
| pilocytic astrocytoma | 3086 | 8.2e-06 |
| lung cancer | 4473 | 2.3e-05 |
| breast carcinoma | 1614 | 4.3e-05 |
| Atopic dermatitis | 944 | 1.9e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 3.4e-04 |
| posterior fossa group A ependymoma | 1511 | 9.9e-04 |
| ovarian cancer | 8491 | 1.1e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 1.8e-03 |
| ulcerative colitis | 2087 | 4.2e-03 |
| invasive ductal carcinoma | 2950 | 5.8e-03 |
| colon cancer | 1475 | 7.8e-03 |
| adrenocortical carcinoma | 1427 | 1.4e-02 |
| Endometriosis | 535 | 2.2e-02 |
| ductal carcinoma in situ | 1745 | 2.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Acquired metabolic disease | 267 | 0.0 | 2.0 |
| Metabolic syndrome X | 155 | 0.0 | 2.0 |
| Type 2 diabetes mellitus | 192 | 0.0 | 2.0 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | 2.000 | 2.0e-07 |
| glioblastoma | 2.800 | 5.2e-06 |
| group 3 medulloblastoma | 3.400 | 9.8e-09 |
| atypical teratoid / rhabdoid tumor | 2.500 | 5.2e-06 |
| medulloblastoma, large-cell | 3.500 | 1.5e-08 |
| primitive neuroectodermal tumor | 3.400 | 7.2e-07 |
| Atopic dermatitis | 1.800 | 1.9e-04 |
| adrenocortical carcinoma | 1.143 | 1.4e-02 |
| non-small cell lung cancer | 2.113 | 2.2e-20 |
| intraductal papillary-mucinous carcinoma... | 1.600 | 1.8e-03 |
| intraductal papillary-mucinous neoplasm ... | 2.500 | 3.4e-04 |
| colon cancer | 3.000 | 7.8e-03 |
| lung cancer | 4.000 | 2.3e-05 |
| breast carcinoma | 1.400 | 4.3e-05 |
| pediatric high grade glioma | 2.500 | 3.9e-07 |
| pilocytic astrocytoma | 1.200 | 8.2e-06 |
| posterior fossa group A ependymoma | 1.200 | 9.9e-04 |
| lung adenocarcinoma | 1.400 | 6.8e-06 |
| psoriasis | 1.800 | 6.1e-101 |
| Endometriosis | 1.324 | 2.2e-02 |
| Breast cancer | 1.900 | 8.4e-09 |
| lung carcinoma | 1.100 | 4.1e-08 |
| ductal carcinoma in situ | 1.200 | 2.6e-02 |
| invasive ductal carcinoma | 1.400 | 5.8e-03 |
| ulcerative colitis | 1.100 | 4.2e-03 |
| ovarian cancer | 1.400 | 1.1e-03 |
| PMID | Year | Title | |
|---|---|---|---|
| 26496610 | 2015 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. | |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. | |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. | |
| 23085020 | 2012 | The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments. | |
| 21269460 | 2011 | Initial characterization of the human central proteome. | |
| 20360068 | 2010 | Systematic analysis of human protein complexes identifies chromosome segregation proteins. | |
| 20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. | |
| 17207965 | 2007 | hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. | |
| 15961401 | 2005 | Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore. | |
| 15815621 | 2005 | Generation and annotation of the DNA sequences of human chromosomes 2 and 4. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 14738735 | 2004 | The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 14699129 | 2004 | Identification of two novel components of the human NDC80 kinetochore complex. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 9585408 | 1998 | The beta subunit of the Sec61 complex facilitates cotranslational protein transport and interacts with the signal peptidase during translocation. |
