Tbio SPATA6 Spermatogenesis-associated protein 6

Protein Summary

Description

Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits.

Uniprot Accession IDs

• Q9NWH7
• Q5T3N7
• Q8WUE6

Gene Name

• SPATA6

Ensembl ID

• ENST00000371843
• ENSP00000360909
• ENSG00000132122
• ENST00000371847
• ENSP00000360913

Symbol

• HASH
• SRF1
• SRF-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.83
tissue sample	0.69
transcription factor perturbation	0.68
histone modification site profile	0.6
tissue	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.69   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 81   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.69   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0