SPACA3
Sperm acrosome membrane-associated protein 3
Protein Summary
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro. The protein encoded by this gene is a sperm surface protein that may be involved in adhesion to the egg prior to fertilization. While the encoded protein has significant similarity to lysozyme at the amino acid level, it has no detectable bacteriocidal activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
- ENST00000269053
- ENSP00000269053
- ENSG00000141316
- ENST00000580599
- ENSP00000463386
- LYC3
- LYZL3
- SLLP1
- SPRASA
- CT54
- LYC3
- LYZC
- LYZL3
- SLLP1
- ALLP17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.82 | ||
protein domain | 0.73 | ||
cellular component | 0.67 | ||
biological process | 0.55 | ||
cell line | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.05 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 56 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.05 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 56 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0