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  6. Nuclear body protein SP140-like protein

Tdark Nuclear body protein SP140-like protein


 Comments

Property Summary

NCBI Gene PubMed Count 7
PubMed Score 0.93
PubTator Score 0.31

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Primary biliary cirrhosis 45 3.081 1.5

Expression

  Differential Expression (19)

Disease log2 FC p
malignant mesothelioma 1.300 4.8e-06
esophageal adenocarcinoma 1.200 2.1e-02
cutaneous lupus erythematosus 1.600 1.1e-02
glioblastoma 1.900 5.3e-04
osteosarcoma -2.041 6.8e-03
juvenile dermatomyositis 1.033 1.6e-10
pancreatic ductal adenocarcinoma liver m... 1.167 3.1e-02
intraductal papillary-mucinous carcinoma... 1.100 4.4e-03
intraductal papillary-mucinous neoplasm ... 1.200 5.8e-03
lung cancer -2.300 1.7e-03
active Crohn's disease 1.056 4.8e-02
ulcerative colitis 1.300 7.7e-07
adult high grade glioma 2.000 2.3e-06
pilocytic astrocytoma 2.100 4.4e-08
posterior fossa group A ependymoma 1.100 7.1e-05
subependymal giant cell astrocytoma 2.153 4.3e-03
lung carcinoma -2.100 4.3e-29
ovarian cancer -1.300 3.7e-05
pituitary cancer -1.200 5.4e-03

Synonym

Accession Q9H930 Q2M375 Q4ZG65 Q9BSP3
Symbols

Gene

SP140L

PANTHER Protein Class (3)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (9)

 GO Function (2)

 GO Component (1)

 Compartment GO Term (2)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

See all...

Gene RIF (3)

PMID Text
26347895 our results show that SP140L is phylogenetically recent member of SP100 proteins and acts as an autoantigen in primary biliary cirrhosis patients.
20800603 Observational study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

AA Sequence 

MAGGGSDLSTRGLNGGVSQVANEMNHLPAHSQSLQRLFTEDQDVDEGLVYDTVFKHFKRHKLEISNAIKK      1 - 70
TFPFLEGLRDRELITNKMFEDSEDSCRNLVPVQRVVYNVLSELEKTFNLSVLEALFSEVNMQEYPDLIHI     71 - 140
YKSFKNAIQDKLSFQESDRKEREERPDIKLSLKQGEVPESPEARKESDQACGKMDTVDIANNSTLGKPKR    141 - 210
KRRKKKGHGWSRMGTRTQKNNQQNDNSKADGQLVSSEKKANMNLKDLSKIRGRKRGKPGTHFTQSDRAPQ    211 - 280
KRVRSRASRKHKDETVDFQAPLLPVTCGGVKGILHKEKLEQGTLAKCIQTEDGKWFTPMEFEIKGGYARS    281 - 350
KNWRLSVRCGGWPLRRLMEEGSLPNPPRIYYRNKKRILKSQNNSSVDPCMRNLDECEVCRDGGELFCCDT    351 - 420
CSRVFHEDCHIPPVESEKTPWNCIFCRMKESPGSQQCCQESEVLERQMCPEEQLKCEFLLLKVYCCSESS    421 - 490
FFAKIPYYYYIREACQGLKEPMWLDKIKKRLNEHGYPQVEGFVQDMRLIFQNHRASYKYKDFGQMGLRLE    491 - 560
AEFEKDFKEVFAIQETNGNS                                                      561 - 580
//

Text Mined References (10)

PMID Year Title
26347895 2015 SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis.
23942779 2013 A genome-wide association study of behavioral disinhibition.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
20800603 2010 Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.