Tbio SP110 Sp110 nuclear body protein

Protein Summary

Description

Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE). The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9HB58
• B4DVI4
• F5H1M1
• Q14976
• Q14977
• Q53TG2
• Q8WUZ6
• Q9HCT8

Gene Name

• SP110

Ensembl ID

• ENST00000258381
• ENSP00000258381
• ENSG00000135899
• ENST00000258382
• ENSP00000258382
• ENST00000358662
• ENSP00000351488
• ENST00000540870
• ENSP00000439558

Symbol

• IPR1
• VODI
• IFI41
• IFI75

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
protein domain	0.99
transcription factor perturbation	0.96
disease perturbation	0.83
tissue sample	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.18   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 321   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.18   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0