Tbio SP100 Nuclear autoantigen Sp-100

Protein Summary

Description

Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• P23497
• B4DDX5
• B8ZZD8
• E7EUA7
• E9PH61
• F8WFE2
• O75450
• Q13343
• Q8TE34
• Q96F70
• Q96T24
• Q96T95
• Q9NP33
• Q9UE32

Gene Name

• SP100

Ensembl ID

• ENST00000264052
• ENSP00000264052
• ENSG00000067066
• ENST00000340126
• ENSP00000343023
• ENST00000409112
• ENSP00000386427
• ENST00000409341
• ENSP00000386404
• ENST00000409897
• ENSP00000386998
• ENST00000427101
• ENSP00000399389

Symbol

• lysp100b

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
biological process	0.97
transcription factor perturbation	0.96
ligand (protein) perturbation	0.83
molecular function	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 517.87   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 288   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 517.87   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0