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Tbio
SOX5
Transcription factor SOX-5

Protein Summary
Description
Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro. This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381381
  • ENSP00000370788
  • ENSG00000134532
  • ENST00000396007
  • ENSP00000379328
  • ENST00000451604
  • ENSP00000398273
  • ENST00000541536
  • ENSP00000441973
  • ENST00000545921
  • ENSP00000443520
  • ENST00000546136
  • ENSP00000437487
  • ENST00000646273
  • ENSP00000493866

Symbol
  • L-SOX5
  • LAMSHF
  • L-SOX5B
  • L-SOX5F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
biological process
0.86
transcription factor
0.84
microRNA
0.8
histone modification site profile
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.54   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.54   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0