Property Summary

NCBI Gene PubMed Count 348
PubMed Score 1085.68
PubTator Score 660.11

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count P-value
periodontitis 269 2.8e-16
non-small cell lung cancer 2798 6.2e-15
chronic lymphosyte leukemia 232 1.4e-13
lung carcinoma 2844 6.2e-08
ulcerative colitis 2087 6.7e-08
psoriasis 6685 2.2e-07
pituitary cancer 1972 3.5e-07
posterior fossa group A ependymoma 1511 8.1e-07
pilocytic astrocytoma 3086 3.7e-06
interstitial cystitis 2299 1.9e-05
lung cancer 4473 2.6e-05
cystic fibrosis 1670 2.9e-04
Atopic dermatitis 944 4.2e-04
juvenile dermatomyositis 1189 4.9e-04
ovarian cancer 8491 1.0e-03
Rheumatoid Arthritis 1170 1.2e-03
Breast cancer 3098 1.4e-03
invasive ductal carcinoma 2950 1.6e-03
tuberculosis and treatment for 3 months 327 1.7e-03
non diabetic and post-ischemic heart failure 200 1.7e-03
intraductal papillary-mucinous adenoma (IPMA) 2956 2.0e-03
primary pancreatic ductal adenocarcinoma 1271 2.1e-03
gastric carcinoma 832 3.0e-03
pancreatic cancer 2300 3.2e-03
urothelial carcinoma 318 5.1e-03
Duchenne muscular dystrophy 602 7.8e-03
osteosarcoma 7933 7.9e-03
medulloblastoma, large-cell 6234 9.8e-03
atypical teratoid / rhabdoid tumor 4369 1.1e-02
adrenocortical carcinoma 1427 1.2e-02
acute quadriplegic myopathy 1157 1.4e-02
limb girdle muscular dystrophy 2B 74 1.7e-02
pediatric high grade glioma 2712 1.8e-02
glioblastoma 5572 2.0e-02
interstitial lung disease 292 2.0e-02
intraductal papillary-mucinous carcinoma (IPMC) 2988 2.1e-02
non primary Sjogren syndrome sicca 840 2.2e-02
pancreatic carcinoma 567 2.3e-02
Bipolar Disorder 266 2.8e-02
head and neck cancer 270 2.8e-02
type II diabetes mellitus and post-ischemic heart failure 89 3.2e-02
aldosterone-producing adenoma 664 3.8e-02
heterozygous familial hypercholesterolemia 1 4.0e-02

Expression

  Differential Expression (43)

Disease log2 FC p
Rheumatoid Arthritis 3.700 1.2e-03
pancreatic cancer 2.600 3.2e-03
interstitial lung disease -2.200 2.0e-02
urothelial carcinoma -2.600 5.1e-03
glioblastoma 1.700 2.0e-02
osteosarcoma 1.460 7.9e-03
chronic lymphosyte leukemia -1.400 1.4e-13
posterior fossa group A ependymoma 2.400 8.1e-07
non diabetic and post-ischemic heart fai... -1.500 1.7e-03
type II diabetes mellitus and post-ische... -1.400 3.2e-02
periodontitis 1.200 2.8e-16
atypical teratoid / rhabdoid tumor 1.600 1.1e-02
medulloblastoma, large-cell -1.300 9.8e-03
Duchenne muscular dystrophy 1.120 7.8e-03
juvenile dermatomyositis 1.033 4.9e-04
limb girdle muscular dystrophy 2B 1.115 1.7e-02
acute quadriplegic myopathy 1.692 1.4e-02
Atopic dermatitis 1.800 4.2e-04
adrenocortical carcinoma -1.827 1.2e-02
primary pancreatic ductal adenocarcinoma 2.481 2.1e-03
tuberculosis and treatment for 3 months -1.600 1.7e-03
non-small cell lung cancer -1.788 6.2e-15
intraductal papillary-mucinous adenoma (... -2.600 2.0e-03
intraductal papillary-mucinous carcinoma... -2.100 2.1e-02
lung cancer -2.800 2.6e-05
ulcerative colitis 4.800 6.7e-08
interstitial cystitis 4.000 1.9e-05
cystic fibrosis 2.600 2.9e-04
pediatric high grade glioma 1.500 1.8e-02
pilocytic astrocytoma 2.500 3.7e-06
non primary Sjogren syndrome sicca -1.200 2.2e-02
pancreatic carcinoma 1.500 2.3e-02
aldosterone-producing adenoma -2.595 3.8e-02
psoriasis -3.000 2.2e-07
invasive ductal carcinoma -1.371 1.6e-03
lung carcinoma -2.100 6.2e-08
heterozygous familial hypercholesterolem... 1.008 4.0e-02
gastric carcinoma 3.800 3.0e-03
Bipolar Disorder 1.002 2.8e-02
ovarian cancer 2.300 1.0e-03
Breast cancer 1.200 1.4e-03
pituitary cancer -4.000 3.5e-07
head and neck cancer 2.100 2.8e-02

 GO Component (2)

Gene RIF (316)

PMID Text
26990535 miR-203 and miR-221 regulate SOCS1 and SOCS3 in essential thrombocythemia
26812031 Increased SOCS3 expression in PBMCs and T cells from patients with ankylosing spondylitis correlates with patient's functional ability, acute-phase reactants and serum pro-inflammatory cytokines.
26707189 Treatment of isolinderalactone increased the protein level of SCOS3, decreased phosphorylation of the STAT3 and suppressed expression of the down-stream genes of the X-linked inhibitor of apoptosis protein
26668321 Data suggest that PCSK9 is involved in regulation of lipid metabolism in hepatocytes by proinflammatory cytokine TNFalpha; induction of lipogenesis and insulin resistance in liver (as seen in obesity) involves up-regulation of both PCSK9 and SOCS3.
26485275 Decreased SOCS3 expression is associated with cholangiocarcinoma.
26464723 A significant relevance involved in SOCS3 gene polymorphisms and infantile asthma development based on a Chinese Han population.
26447993 Our findings suggest that the rs4969170A>G polymorphism of SOCS3 gene may be used as a prognostic predictor for HCC patients who underwent surgical treatment.
26429311 Dysregulation of SOCS3 functions can cause a variety of diseases, including allergy, autoimmune diseases, inflammation and cancer. (Review)
26416445 induction of SOCS3 may be a novel mechanism by which FXR exerts its anti-hepatocellular carcinoma effects
26393582 In hepatocellular carcinoma tumor tissues, SOCS3 showed an increased methylation frequency and intensity compared with that in the adjacent non-tumor tissues.
26306032 crucial requirements for IL-31 signaling and its counter-regulation by SOCS3
26261631 Suggest racial/ethnic- and/or sex-specific association between the SOCS3 A+930-->G (rs4969168) SNP and serum APOA1/LDL cholesterol levels in some Chinese populations.
26252772 SOCS3 down-expression induces lineage commitment towards erythroid progenitor cell fate by activation of erythroid-specific gene in HSCs
26246577 SOCS3 is an inducible host factor that regulates virus egress during Ebola virus infection.
26178755 The role of the SOCS3 protein in the Jak/stat3 pathway is to mediate different mechanisms for preterm and term labor processes in the placenta.
26072679 Varicella-zoster virus infection induces SOCS3 expression, resulting in modulation of type I interferon signaling and viral replication.
26047583 Epigenetic inhibition of SOCS3 is regulated by miR1264 which specifically targets DNMT1 transcript.
25943894 Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of suppressor of cytokine signaling 3 (SOCS3)
25939384 Data indicate that suppressor of cytokine signaling 3 (SOCS3) knockdown markedly increases the abundance of TANK-binding kinase 1 (TBK1).
25849377 Lower expression of SOCS3 is associated with response to radiation in cervical cancer.
25847945 alveolar macrophages can secrete SOCS1 and -3 in exosomes and microparticles, respectively, for uptake by alveolar epithelial cells and subsequent inhibition of STAT activation.
25840690 there is a regulatory pathway consisting of miR-30, SOCS3, and Jak/STAT3 in GSCs, and targeting this pathway may be a promising strategy to treat glioma.
25827060 Data suggest that SOCS3 plays critical negative role in regulation of expression of TRAIL (TNF-related apoptosis-inducing ligand) in endoplasmic reticulum stress in macrophages via Jun N-terminal kinase/AP-1 transcription factor signaling.
25770161 Results so that AA genotype carriers had significantly higher levels of SOCS3 RNA and have greater susceptibility to GO
25764157 Reduced SOCS3 expression in eosinophils, lead to an inhibition of GATA-3 and FoxP3, impaired eosinophil migration, adhesion and degranulation.
25744243 Enhanced expression of suppresser of cytokine signaling 3 inhibits the IL-6-induced epithelial-to-mesenchymal transition and cholangiocarcinoma cell metastasis.
25730073 SOCS-3 may have a role in dyslipidemia in China in the Xinjiang Uygur population
25695729 SOCS3 negatively regulates proliferation and angiogenesis of NCI-H446 cells and that HIF-1alpha is required in this process. The results also suggested a suppressive role of SOCS3 in Akt signaling, but not STAT3 signaling to block HIF-1alpha expression
25689935 H. pylori infection induced hepatic insulin resistance by the c-Jun/miR-203/SOCS3 signaling pathway and provide possible implications with regard to resolving insulin resistance.
25648699 Loss of CAST in angiogenic ECs facilitates mu-calpain-induced SOCS3 degradation, which amplifies pathological angiogenesis through interleukin-6/STAT3/VEGF-C axis.
25640370 the present study demonstrated that advanced grade of urothelial bladder carcinoma was significantly associated with lowered mRNA expression of SOC-3 as well as elevated urinary levels of proinflammatory cytokines and CK-18.
25545374 SOCS3 overexpression is associated with early relapse of mucosal inflammation in in ulcerative colitis.
25458989 SOCS3 and STAT3 are the major controllers of the outcome of infection with Mycobacterium tuberculosis. (Review)
25377316 Increased expression of SOCS3 may serve to perpetuate "inflammation" by promoting TNF-alpha production and limiting epithelial repair in response to commensal microflora.
25286386 This study showed that there was significantly increased levels of SOCS-2 mRNA in elderly and Alzheimer's disease brain.
25283858 Hepatitis C virus infection triggers endoplasmic reticulum stress and downregulates IRS1 and IRS2 through upregulation of SOCS-3.
25283845 upregulated in choriodecidua following labor
25261987 Low expression of SOCS-3 is associated with gastric cancer.
25207681 A differential expression of both SOCS1 and SOCS3 was observed between PBMCs and neutrophils in patients with Behcet's disease.
25132761 No correlations were reported between adipokine profile, HOMA-IR values and hepatic expression of the SOCS-3 gene in chronic hepatitis C.
25125049 This study suggest that SOCS3 regulates IL-6 signaling as an antagonist in CSF.
25034082 found SOCS3 gene polymorphisms are not associated with occurrence of adolescent idiopathic scoliosis (AIS) but the polymorphism(rs4969168)is associated with abnormal growth pattern of AIS, indicating SOCS3 gene might be a disease-modifying gene of AIS
25019494 In conclusion, miR-221 could accentuate interferon's anti-hepatitis C virus effect by targeting SOCS1 and SOCS3.
24996521 Reg3A overexpression promoted cell growth in pancreatic cancer. SOCS3 is a key target in cancer by inhibiting cell growth and inducing apoptosis. SOCS3 negatively regulated Reg3A-mediated cell growth in pancreatic cancer.
24969884 Down- regulation of both SOCS-1 and SOCS-3 genes in resistant cells.
24951315 This study showed an imbalance of SOCS1 and SOCS3 transcription in MS patients, and a moderated negative correlation between them (Spearman's r=-0.57; p=0.0003).
24939297 Results show that the cytokine signaling-3 (SOCS3) expression was significantly elevated in both the liver tissue and peripheral blood mononuclear cells (PBMCs) from patients with HBV-induced acute-on-chronic liver failure (HBV-ACLF).
24932998 High levels of STAT3 expression were associated with early stages of breast cancer development and patients in the control group with obesity showed higher expression of SOCS3 regarding overweight
24931262 Data demonstrate that the serum levels of SOCS3 and STAT3 were increased in childhood atopic dermatitis (AD) compared with controls.
24883303 IL-8 and CXCR2 expression was distinctly uncommon as opposed to IL-6, VEGF and SOCS-3, which were detected in the vast majority of cases.
24833710 Cannabinoids induce autophagy in a model of intestinal epithelium, an effect that leads to the reduction of SOCS3.
24827536 a reduction in function, rather than a reduction in expression of SOCS3 accounts for the unregulated expression of IL-17 in SS, and may play a crucial role in aetiopathogenesis.
24762139 Decreased SOCS3 and IL-35 plasma levels and increased Th1/Th2 cytokine ratios in RPL cases pointed out the supression of anti-inflammatory process and this suppression might play an important role in the pathogenesis of idiopathic RPL.
24711032 rs4969168 polymorphism of SOCS3 gene is associated with IR in ethnic Uygur population from Xinjiang, China.
24659790 These results demonstrate a role for SOCS3 in regulating proinflammatory TNF-alpha signal transduction and reveal a novel immune-modulatory mechanism by which HCV suppresses inflammatory responses
24636575 Hepatitis B virus could induce both SOCS-1 and 3 expression regardless of endogenous interferon level.
24633048 SOCS3 promoter hypermethylation status has a favorable prognostic value in GBM patients because of whole genome methylation status. Particularly, the hypermethylation of the SOCS3 promoter indicates positive G-CIMP status.
24631457 AP1 activation and SOCS3 induction by EPAC1 in human umbilical vein endothelial cells occur independently of c-Jun phosphorylation on Ser63.
24607843 miR-221 directly inhibits the expression of SOCS3 and IRF2.
24595859 SOCS signaling is involved in the regulation of immune cells, and recent findings suggest that SOCS proteins, especially SOCS1 and SOCS3, are often dysregulated in a wide variety of autoimmune diseases. [review]
24593195 Elevated SOCS-3 overexpression is associated with tumor aggressiveness in renal cell carcinoma.
24584041 Elevated levels of cytokines were associated with high mycobacteria-specific IgG titres as well as SOCS3 mRNA and progression of moderate-to-severe disease.
24531711 We investigated the role of SOCS3 in p53- and PTEN-mediated activation of inflammatory feedback loop and malignant transformation
24491408 let-7 re-expression enhanced cytoplasmic expression of suppressor of cytokine signaling 3 (SOCS3), which blocks STAT3 activation by JAK2
24476004 Inhibition of SOCS3 expression promoted the proliferation, migration, and invasion of HepG2 cells.
24414258 overexpression of SOCS-3 protects against LPS-induced adhesion molecules expression and airway inflammation.
24354892 The wild-type and pathological mutants of JAK2 are enzymatically equivalent and equally susceptible to inhibition by SOCS3.
24212839 Hepatitis C genotype 1 patients who were responders to interferon-based therapy had a high frequency of multiple protective polymorphisms in the myxovirus resistance protein, osteopontin and suppressor of cytokine signaling 3 genes.
24131863 methylation of SOCS1, SOCS2, SOCS3 and CISH is infrequent in Ph-ve MPN.
24088176 SOCS3-induced pro-inflammatory effects were due, at least in part, to its role in controlling activation and nuclear accumulation of nuclear factor-kappaB and activity of phosphatidylinositol 3-kinase.
24084073 levels were diminished in chronic rhinosinusitis with nasal polyps sinonasal tissues
23910692 SOCS3 and Foxp3 are coexpressed in Treg cells in human nasal mucosa and that SOCS3 negatively regulates Foxp3 expression in human airway mucosa, possibly through phosphorylation of STAT3.
23900445 Variations in genes AGRP, CPE, GHRL, GLP1R, HTR2A, NPY1R, NPY5R, SOCS3 and STAT3 showed modest associations with BMI in European Americans.
23898208 Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of suppressor of cytokine signaling 3 (SOCS3)
23894411 a novel mechanism by which miR-19a may augment JAK-STAT signal transduction via control of SOCS3 expression
23824571 Data indicate that SOCS-3, STAT-3, and the status of extragastric nodal metastasis were identified to be the independent factors of the lymph node metastasis from gastric cancer (GC).
23803735 PPARgamma-induced SOCS3 expression represses Th17 cell differentiation.
23782265 Data suggest flavanoids (naringenin, flavone) induce expression of SOCS3 and suppress STAT3 (signal transducer and activator of transcription 3) signaling in vascular endothelial cells; thus, dietary components can act as anti-inflammatory agents.
23686487 these findings show that ribosomal stress-induced SOCS3 plays a novel regulatory role in epithelial BAFF production
23554973 Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of suppressor of cytokine signaling 3 (SOCS3)
23553658 Results suggest that SOCS-1/3 participates in FGF-2 modulation of RANKL expression in paget's disease of bone.
23545584 These results demonstrate the differential expression of SOCS1 and SOCS3 in atherosclerosis.
23490372 Authors found that the rs4969170 AA genotype and rs4969170 A allele frequency were significantly more common in the insulin-resistant group than the non-insulin-resistant group among chronic hepatitis C patients.
23472246 Levels of STAT1 andor the protein expression of its negative regulators, PIAS1 and SOCS3, may be a good predictor of hepatitis C virus response to therapy
23454976 studies reveal that SOCS3 targets specific JAK-cytokine receptor pairs and explains the mechanism and specificity of SOCS action
23432547 SOCS3 was methylated in most mantle cell lymphoma tumors & cell lines, in which SOCS3 transduction increased apoptosis, activity, downregulated NF-kappaB-p65, CCND1, BCL2 & BCL-XL,& lessened IL-10-induced STAT3 activation.
23430957 HDAC8 plays an important role in the modulation of SOCS1 and SOCS3 by curcumin.
23430705 SOCS3 silencing is able to promote epithelial-mesenchymal transformation in hepatocallular carcinoma cells by changing the phenotypic characteristics and modulating characteristic markers.
23392112 An age-related impairment in normal muscle stem cell function is influenced by SOCS3 protein.
23375208 Chronic rhinosinusitis with polyps and without polyps is associated with increased expression of SOCS1 and SOCS3
23360921 In resected pancreatic cancer, carriers of a minor allele for rs8064821 (SOCS3) were associated with a survival advantage compared with noncarriers with an additional 2-year survival if both minor alleles were present.
23335796 SOCS33 expression in coronary artery smooth muscle cells is down-regulated by DNA methylation and NF-kappaB ineraction with STAT3.
23320781 Expression of M. tuberculosis-induced suppressor of cytokine signaling (SOCS) 1, SOCS3, FoxP3 and secretion of IL-6 associates with differing clinical severity of tuberculosis.
23302305 SOCS3 definitely plays roles in regulating Pyk2 signaling and cell motility in A549 cells. Decreased SOCS3 induced by methylation may confer a migration advantage to A549 cells.
23274199 Data indicate that tocilizumab enhanced the interferon-induced phosphorylation of STAT1 and inhibited SOCS3 expression and the phosphorylation of both STAT3 and ERK.
23229770 in patients with eosinophilic esophagitis, the esophagus expresses and synthesizes high levels of SOCS1 and SOCS3 proteins
23226414 The present study investigates the involvement of the IL-6 family of cytokines, activation of the transcription factor STAT3 and the role of SOCS3 in regulating excitotoxic neuronal death.
23206599 In this review SOCS3 (and PTEN) were found to act as negative regulators in such processes as cytoskeleton assembly and axon regeneration.
23185530 Myocardial infarction is distinguished by the up-regulation of SOCS3 and FAM20A genes within first days in the vast majority of patients.
23164156 Intrahepatic SOCS1/3 mRNA levels are associated with cirrhosis but do not predict virological response to therapy in chronic hepatitis C.
23154639 The colon epithelial cell line Caco-2 was stimulated with interferon gamma, interleukin -4 prostaglandin E(2) to allow correlations between SOCS3 expression with STAT1, STAT6 and cyclic amp signaling.
23152563 SOCS3 profoundly enhances Fas signal-induced apoptosis by suppression of NF-kappaB-dependent Bfl-1 expression.
23133602 In HCV-HIV coinfected patients treated with PegIFNalpha and ribavirin, SVR is associated with IL28B rs8099917 polymorphism; HCV treatment-induced neutropenia and thrombocytopenia are associated with SOCS3 rs4969170 polymorphism
23111066 Data indicate that knockdown of HDAC8 resulted in the increased expression of SOCS1 and SOCS3, and overexpression of SOCS1 and SOCS3 significantly inhibited cell growth and suppressed JAK2/STAT signaling.
23108375 Using two renal cellular models&SOCS-3 siRNA knockdown,we studied SOCS-3 effects on oncostatin M-induced STAT activation, differentiation and proliferation.SOCS-3 knockdown resulted in enhanced pSTAT1/3 phosphorylation & epithelial diff'n.
23046072 results suggested that there is no marked association between SOCS3 gene promoter region polymorphisms and the risk of developing metastatic colorectal cancer
23033269 Higher SOCS3 expression in human T cells favors T helper type 17 cells. Therefore, increased SOCS3 expression in human tuberculosis may reflect polarization toward IL-17-expressing T cells as well as T-cell exhaustion marked by reduced proliferation.
23030674 SOCS3 expression is increased in human bladder epithelial cells when stimulated with a uropathogenic Escherichia coli strain.
23028842 SOCS3 functions as a tumor suppressor gene in head and neck squamous cell carcinoma with relevance on proliferation and invasion processes.
22957141 Reduced expression of miR122 contributes to decreased SOCS3 expression via promoter methylation.
22951153 Obese subjects showed a decreased ability to produce IFN-alpha and IFN-beta in response to TLR ligands; this response was associated with increased basal levels of SOCS3 but not SOCS1.
22925925 SOCS3 is involved in repressing the M1 proinflammatory phenotype, thereby deactivating inflammatory responses in macrophages.
22848642 LPS induces upregulation of MCP-1 in DSCs, which may play a critical role in inhibiting the cytotoxicity of NK cells partly by promoting SOCS3 expression
22820139 Over-expression of SOCS-3 mRNA from peripheral blood of NHL patients correlates with advanced disease and poor response to treatment.
22787435 Bcr-Abl may critically requires tyrosine phosphorylation of SOCS-1 and SOCS-3 to mediate tumorigenesis when these SOCS proteins are present in cells.
22768656 High SOCS3 is associated with idiopathic short stature.
22745793 The results demonstrate that SOCS1 and SOCS3 each play a functionally distinct role in modulating TLR3, JAK/STAT, and CXCR4/CXCR7 signaling in hMSC.
22739986 the depletion of SOCS3, as well as the chemical inactivation of PI3K activity in psoriatic keratinocytes, definitively unveils the role of PI3K/AKT cascade on the resistance of diseased keratinocytes to apoptosis.
22739025 induction of DNMT1 expression in the chronically inflamed colon may release IL-6 signaling towards signal transducer and activator of transcription 3 from inhibition through SOCS3 increasing the propensity to malignant transformation
22632162 Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of suppressor of cytokine signaling 3 (SOCS3)
22613986 present study demonstrates that Ang II induces angiogenic factors production partly via AT1/ JAK2/STAT3/SOCS3 signaling pathway in MHCC97H cells
22591635 SOCS3 protein is an important regulator of cytokine signaling associated with inflammatory bowel disease and IBD-colorectal cancer[review]
22587677 no significant difference in mRNA expression in adipose and placental tissue obtained from pregnant women with and without gestational diabetes mellitus
22576756 both SOCS-3 mRNA and SOCS-3 protein are expressed in human arthritic chondrocytes and affect cellular responses involved in cartilage pathology.
22575502 these results demonstrate that in results demonstrate that in human endothelial cells resistin up-regulates SOCS3 expression and activates STAT3 transcription factor.
22574771 review of biology and mechanism of action of suppressor of cytokine signaling 3 [review]
22560881 results suggest modulation of SOCS3 expression may represent a novel mechanism through which FXR activation could selectively affect cytokine bioactivity in inflammation response
22547065 Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.
22535619 High SOCS3 expression is associated with mucosal relapse in ulcerative colitis.
22532676 IFN-gamma-induced phosphorylation of STAT-1 and transcription of CIITA were suppressed in Kaposi's sarcoma-associated herpesvirus-inoculated endothelial cells via a mechanism involving SOCS3 (suppressor of cytokine signaling 3).
22488585 SOCS3 epigenetic silencing was occasionally detected in immunodeficiency-related non-Hodgkin lymphoma.
22487676 SOCS1 and SOCS3 mRNA and protein expression was significantly increased in the nasal mucosa and mononuclear leukocytes of patients with mild and moderate/severe persistent perennial allergic rhinitis.
22425648 SOCS3 expression in the paraventricular nucleus was inversely related to serum leptin.
22342841 SOCS3 bound and directly inhibited the catalytic domains of JAK1, JAK2, and TYK2 but not JAK3 via an evolutionarily conserved motif unique to JAKs. Mutation of this motif led to the formation of an active kinase that could not be inhibited by SOCS3.
22311708 ERK-dependent regulation of transcriptional activity that requires codependent activation of multiple transcription factors within the same region of the SOCS-3 gene promoter.
22294695 keratinocytes have a cell type-specific impaired capacity to up-regulate SOCS3 which may crucially determine the course of chronic inflammatory skin diseases.
22266116 TNF-alpha inhibits insulin signaling by increased phosphorylation of IRS-1(Ser307) and insulin receptor(Tyr960), and by increasing SOCS3 levels, all of which block normal insulin signal transduction.
22260693 One important aspect of SOCS-3 functionality is its role as the specificity determinant within an E3 ubiquitin ligase complex which targets cellular substrates for polyubiquitylation and proteasomal degradation. [Review]
22093833 SOCS3 is an important factor for lipid metabolism and a potential drug-target for treatment of widespread obesity.
22084247 a new biological activity for CUEDC2 as the regulator of JAK1/STAT3 signaling and the mechanism by which SOCS3 has been linked to suppression of the JAK/STAT pathway
22075701 SOCS3 transgene expression in immature B cells regulates both the maintenance of the germinal center and IgE affinity maturation during a T cell-dependent immune response.
21934357 Epigenetic dysregulation of the SOCS3 gene may interfere with the cellular response to the complex cytokine network thus supporting survival and expansion of multiple myeloma cells.
21898505 Glucocorticoids interfere with IL-6-induced expression of the feedback inhibitor SOCS3, thereby leading to enhanced expression of acute-phase genes in hepatocytes.
21892197 The polymorphism rs4969168 within or near the SOCS3 gene has a significant effect in the Han nationality, while rs9892622 was associated with obesity in Uygur and Kazakh nationalities in Xinjiang of China.
21876460 Deregulated expression of pSTAT3 and SOCS3 might possess potential roles in the development and progression of human cutaneous melanoma.
21765854 Eosinophils are able to transcribe and translate SOCS3 protein and can contribute to the regulation of the Th1/Th2 balance through SOCS3 production.
21734367 SOCS-1 and SOCS-3 can prevent tubulointerstitial fibrosis by inhibiting TEMT, which may be connected with the activation of STAT1 and STAT3
21590492 our findings suggest that SOCS3 inactivation by promoter hypermethylation is mutually exclusive to EGFR activation in gliomas and preferentially promotes glioma cell invasion through STAT3 and FAK activation.
21547863 concurrent strength and endurance training reduces fat mass and serum leptin and the ratio leptin/fat mass without significant effects on vastus lateralis OB-Rb protein expression; training does not increase the basal expression of SOCS3 protein in humans
21545585 gene expression induced by live non-pathogenic Lactobacillus and Streptococcus
21490101 Our study demonstrates that the alpha-IFN resistance of HCV core mutants is attributable to upregulated overexpression of the cellular interferon signal attenuator SOCS3 and that this upregulation is caused by overexpression of interleukin-6.
21481788 data describe the involvement of IL-6 transsignaling/Stat3/Socs3 in pancreatic intraepithelial neoplasia progression and pancreatic ductal adenocarcinoma development
21478033 SOCS3 influences myoblast differentiation.
21451109 In this study, we describe a unique signaling pathway responsible for the SOCS3-mediated downregulation of proinflammatory cytokines
21385272 Signal transducer and activator of transcription 3 (STAT3) and Suppressor of Cytokine Signaling (SOCS3) balance controls cytotoxicity and IL-10 expression in decidual-like natural killer cell line NK-92.
21360047 Suppressor of cytokine signalling protein SOCS3 expression is increased at sites of acute and chronic inflammation
21354254 suppressor of cytokine signaling 3 regulates cardiac cell signaling crosstalk, between NF-kappaB and p-STAT3, under hypoxic stress
21337543 found higher levels of SOCS-1/3 mRNA levels in CD4(+) T cells of HIV-infected patients than in healthy controls
21325601 Serum amyloid A overrides Treg anergy via monocyte-dependent and Treg-intrinsic, SOCS3-associated pathways.
21308719 SOCS-3 may be one of proteins which influence ability of TRAIL and resveratrol to cause programmed cell death in prostate cancer.
21275162 Huatan Tongluo Granule upregulates SOCS3 and downregulates TNFa patients with acute cerebral infarction.
21263153 SOCS3 overexpression in K562 cells and in primary erythroid cells recapitulated the growth inhibition induced by Sox6, which demonstrates that SOCS3 is a relevant Sox6 effector.
21190606 High glucose could produce morphological and ultrastructural changes in renal tubular epithelial cells and induce up-regulation of SOCS-1/3 expression.
21173340 Data suggest that increased plasma soluble gp130/soluble IL-6R/IL-6 ratio and reduced membrane transsignaling gp130 expression could contribute to decreased SOCS-3 expression and subsequent reduction in SOCS-3 antiinflammatory activity in preeclampsia.
21042758 Insights into the development of applications of SOCS3 gene therapy for lung cancer and, possibly, other human cancers.
21029588 SOCS3 expression is reduced in placenta of women with intrahepatic cholestasis of pregnancy.
20934424 SOCS1 and 3 may control chemotaxis and adhesion
20840058 increased expression in kidney and liver of patients who died of anaphylactic shock
20717995 SOCS3 hypermethylation may be involved in the pathogenesis of prostate cancer and could identify a tumor subset with an aggressive behavior.
20690084 Data conclude that SOCS-3 polymorphism is not a genetic risk factor for RA in Chinese patients.
20690084 Observational study of gene-disease association. (HuGE Navigator)
20689596 Data propose that EBV protein Zta activates SOCS3 protein as an immune escape mechanism that both suppresses optimal IFNalpha secretion by human monocytes and favors a state of type I IFN irresponsiveness in these cells.
20673263 Authors detected differential expression of SOCS3 between TB patients and LTBIs, but not between TB patients and NIDs, and decreased expression of SOCS3 in T-cells from LTBIs as compared with NIDs.
20631305 Data suggest that SOCS3 may allow HIV-1 to evade the protective innate immune response within the CNS, allowing the recurrence of viral replication and, ultimately, promoting progression toward HAD.
20631305 Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of suppressor of cytokine signaling 3 (SOCS3)
20588308 Observational study of gene-disease association. (HuGE Navigator)
20504769 oral administration of HA900 modulates Th-1-type autoimmune disease and inflammation by up-regulating SOCS3 expression and down-regulating pleiotrophin expression via TLR-4 in intestinal epithelial cells
20503287 Observational study of gene-disease association. (HuGE Navigator)
20484656 Interferon-gamma-induced SOCS3 expression leads to inhibition of IL-6-induced signal transducer and activator of transcription (STAT)3 activation and interleukin (IL)-6-dependent expression of anti-, but not pro-inflammatory, target genes.
20478455 results suggest that pro-inflammatory cytokines induced SOCS-3 expression. SOCS-3 induction suggests playing important role in negative feedback, suppressing serious destruction of periodontal tissue through a chemokine-dependent mechanism.
20468064 Observational study of gene-disease association. (HuGE Navigator)
20438785 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20433750 Higher mRNA expression levels of SOCS1, 3, 4 and 7 are significantly associated with earlier tumour stage and better clinical outcome in human breast cancer.
20406964 Observational study of gene-disease association. (HuGE Navigator)
20398276 Data demonstrate that SOCS proteins are expressed in human melanoma cell lines and their modulation can influence the responsiveness of melanoma cells to IFN-alpha and IFN-gamma.
20375166 SOCS3 suppresses hepatitis C virus replication in an mTOR-dependent manner.
20372794 SOCS1 and SOCS3 expression attenuates Lck-mediated cellular transformation
20351777 Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3
20335309 SOCS-3 is a novel modulator of FGF-2-regulated cellular events in prostate cancer.
20237496 Observational study of gene-disease association. (HuGE Navigator)
20231901 SOCS-3 and PIAS-3 upregulation impairs IL-12-mediated interferon-gamma response in CD56 T cells in HCV-infected heroin users
20155426 Deficient expression of SOCS3 is associated with an aggressive phenotype and portends a poor clinical outcome in breast carcinoma.
20137421 Up regulation of SOCS1 and SOCS5 expression and down-regulation of SOCS3 and CIS may correlate with the development of a Th1 mediated immune response in Vogt-Koyanagi-Harada disease.
20136974 Probiotic administration increased expression of SOCS-2 and SOCS-3 in Helicobacter pylori infection to limit inflammatory signaling.
20130595 Forced expression of SOCS3 and SHP-1 inhibits IFN-alpha signaling in psoriatic T cells.
20067961 Saturated fat and carbohydrates, components of the high fat meal, known to induce oxidative stress and inflammation, also induce an increase in LPS, TLR-4, and SOCS3
20005910 SOCS3 expression was increased in liver from patients with HBV-infection and this correlated with the severity of liver inflammation.
19951849 findings suggest that overexpression of p-STAT3 (Tyr705) occurs in urothelial carcinoma, and that pathways other than SOCS3 may contribute to its activation in this cancer
19913854 Dysregulation of sterol regulatory element binding protein-1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling-3.
19803812 interactions between the molecular expression of SOCS3, IRS-1 and phospho-AKT mediated by the genotype 1b virus
19737863 overexpression of SOCS3 in T cells reduces IL-17 and accelerates atherosclerosis.
19643162 The objective of this study was to investigate the effect of SOCS-3 on TNFalpha-induced signalling in beta cells.
19634073 Our results show that androgenic -regulation of SOCS-3 leads to inhibition of prolif-eration and secretion in human prostate cancer.
19617629 adiponectin augmented the expression of A20, suppressor of cytokine signaling (SOCS) 3, B-cell CLL/lymphoma (BCL) 3, TNF receptor-associated factor (TRAF) 1, and TNFAIP3-interacting protein (TNIP) 3.
19595407 These results suggest that RSV infection escapes the innate antiviral response by inducing SOCS1, SOCS3 or CIS expression in epithelial cells.
19592492 a role for SOCS1 and -3 in the seemingly paradoxical hyperresponsive state in cells deficient in IL-18Ralpha, supporting the concept that IL-18Ralpha participates in both pro- and anti-inflammatory responses
19543316 SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.
19524687 SOCS3, as negative regulators of cytokine signaling, might maintain homeostasis by regulating multiple signaling pathways and reverse cell malignant behavior.
19423540 Observational study of gene-disease association. (HuGE Navigator)
19258923 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19231005 Liver expression of SOCS3 is a stronger baseline predictor of antiviral response than viral genotype in determining response to hepatitis c.
19229050 SOCS3 tyrosine phosphorylation may be a novel bio-marker of myeloproliferative neoplasms resulting from a JAK2 mutation, JAK2 H538QK539L or JAK2 F537-K539delinsL mutations
19225535 SOCS3 inhibits TPO-induced megakaryocytic proliferation in normal and primary myelofibrosis but not the spontaneous growth in primary myelofibrosis
19164812 Suppressors of cytokine signaling modulate JAK/STAT-mediated cell responses during atherosclerosis.
19129540 Inhibition of cytokine response by IL-25 occurred via a p38 Map kinase-driven Socs-3-dependent mechanism
19115200 SOCS3 is a tumor suppressor in breast cancer cells that is regulated by PRL
19083014 SOCS3 genetic variants play a role in human obesity.
19083014 Observational study of gene-disease association. (HuGE Navigator)
19077438 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19052638 There is no strong effect of the common genetic variation within the SOCS3 gene on the development of type 2 diabetes mellitus.
19052638 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
19036437 Enhanced SOCS-3 gene expression could promote IL-10 production by placental trophoblast cells, suggesting that SOCS-3 may play an important role in regulation of cytokine induced anti-inflammatory response in placental trophoblasts.
19027008 These results suggest that the interaction of SOCS3 with MAP1S and the integrity of the microtubule cytoskeleton play an important role in the negative regulation of SOCS3 on IL-6 signaling.
18989459 influenza A viruses not only suppress IFNbeta gene induction but also inhibit type I IFN signaling through a mechanism involving induction of the SOCS-3 protein
18986700 increased ratio of sgp130/sIL-6R production and/or reduced sIL-6R production combined with down-regulation of IL-6R and SOCS-3 expression in trophoblasts may lead to less cytokine inhibitory activity in preeclampsia placentas
18971287 CCL11 induces SOCS1 and SOCS3 expression in murine macrophages, human monocytes, and dendritic cells and inhibits GM-CSF-mediated STAT5 activation and IL-4-induced STAT6 activation in a range of hematopoietic cells.
18952062 SOCS3 negatively regulates IL-1beta-induced MUC8 gene expression.
18941624 SOCS3 expression in skeletal muscle is not up-regulated in women, despite very high serum leptin concentrations compared to men
18820827 difference in SOCS1, SOCS2 and SOCS3 transcript levels between normal individuals and SLE patients is not statistically significant
18815196 SOCS3 promoter methylation iss detected in 32% of patients with idiopathic myelofibrosis suggesting a role for SOCS3 methylation in this disorder.
18770864 The methylation of SOCS3 may be involved in the pathogenesis of glioblastoma multiforme and in the resistance of this neoplasm to conventional treatment.
18752121 Constitutive and altered SOCS-3 expression may have potential roles in a subset of hepatocellular carcinoma patients.
18687693 SOCS-3 acts as a negative regulator of the cell cycle progression under E2F/DP-1 control by interfering with heterodimer formation between DP-1 and E2F
18660489 Observational study of gene-disease association. (HuGE Navigator)
18656467 monocyte SOCS3 correlated with glomerular filtration rate, urea and diastolic blood pressure
18636124 Observational study of gene-disease association. (HuGE Navigator)
18571793 Oncostatin M stimulation of astrocytes leads to induction of SOCS-3 expression and activation of ERK1/2 and JNK pathways.
18549612 There is a statistically significant difference in the expression level of socs3 mRNA in myelo-proliferative disease patients between jak2v617f mutation positive group and negative group.
18538318 the lymphadenitis due to M. tuberculosis was associated with activated lysozymes and SOCS-3 but not SOCS-1 compared to controls, which may play a role in the long-term bacterial replication and altered immune modulation characteristic of the disease.
18507841 SOCS3 negatively regulates cell motility and decreased SOCS3 induced by methylation may confer a migration advantage to A549 cells. This suggest a negative role of SOCS3 in PYK2 signaling: previously unidentified regulatory mechanism for PYK2 function.
18440067 The methylation status of CpG islands of SOCS3 genes in chronic myeloproliferative neoplasms.
18414649 Data found that the level of TLR2 and SOCS-3, genes associated with atopy in the children, were significantly downregulated by presence of S. haematobium infection.
18250407 SOCS3 and SOCS1 critically regulate influenza A virus-triggered innate immune responses by inhibiting type I interferon alphabeta receptor (IFNAR)1 antiviral signaling and differentially modulating inflammatory signaling pathways.
18240972 Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation.
18199397 SOCS-3 may cause tissue damage indirectly in multiple organ dysfunction syndrome.
18097573 Reduced expression of SOCS-3 is closely related to lymph node metastasis. Therefore, SOCS-3 may be a good predictor for lymph node metastasis.
18055217 We conclude that endogenous SOCS3 inhibits AP-1 activity through blocking of JNK phosphorylation.
18045952 SOCS-3 inhibits androgen-stimulated proliferation by influencing cell cycle regulation in a prostate cancer cell line.
17935223 The infection of cells with adenovirus CN305 (AdCN305)-SOCS3 and AdCN305-cpp-SOCS3 resulted in dramatic cytotoxicity in liver tumor cells.
17895321 SOCS3 remained significantly unchanged in polycystic ovarian syndrome women
17881539 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17703412 Observational study of gene-disease association. (HuGE Navigator)
17668875 SOCS3 expression may influence the response to antiviral therapy and genotype 1b hepatitis C virus might induce its up-regulation. This may account for the different responses to therapy between genotype 1-infected and genotype 2-infected patients.
17636039 This study details a novel mechanism of SOCS3 up-regulation by PGE2 in breast cancer cells that appears to be STAT independent and involve Sp1 binding to the promoter.
17605868 SOCS-3 expression of naive T cells was up-regulated significantly after IL-2 stimulation; expression was down-regulated markedly after OVA(323 - 329) antigen stimulation.
17589943 Increased expression of mucosal SOCS3, but not of SOCS1, may play a critical role in the development of the colonic inflammation of ulcerative colitis.
17530721 Interleukin-6 (IL-6) was expressed in monocytes and B cells, IL-10 in monocytes, and suppressor of cytokine signaling 3 in monocytes and T cells from patients with active disease.
17445271 Observational study of gene-disease association. (HuGE Navigator)
17445271 our data do not suggest evidence for a major role of the respective SNPs in SOCS3 in the pathogenesis of extreme obesity in our study groups
17438093 Altered SOCS gene expression leads to increased cell signaling through the ERK-MAPK pathway and may play a role in disease pathogenesis by enhancing glioblastoma multiforme radioresistance.
17374732 SOCS3 may possibly play a role in IL-6 resistance in at least a fraction of tumors.
17363902 This is the first demonstration of SOCS-mediated ubiquitination and routing of a cytokine receptor and its impact on maintaining an appropriate signaling output.
17325857 a defect in expression of SOCS-2 and SOCS-3 genes may be crucial for the IGF-I hypersensitivity and progressive increase in erythroid cell population size characteristic of Polycythemia vera.
17297444 SOCS3 overexpression reduced proliferation.
17273770 inactivation of the SOCS3 gene by hypermethylation may be involved in the promotion of malignant behavior of melanomas
17264307 Using RT-PCR, we demonstrated for the first time that neutrophils express mRNA for SOCS-3. It is interesting that IL-4 increased expression of SOCS-3 at the mRNA and protein levels.
17241887 SOCS-3 epigenetic silencing is responsible for sustained IL-6/STAT-3 signaling and enhanced Mcl-1 expression in cholangiocarcinoma
17148681 Collectively, our results show that SOCS-3 antagonizes regulation of cellular events by cAMP and is expressed in human prostate cancer.
17138568 SOCS3 binds the phosphorylated immunoreceptor tyrosine-based inhibitory motif (ITIM) of sialic acid-binding immunoglobulin-like lectin (siglec) 7 and targets it for proteasomal-mediated degradation.
17083795 Upon LPS stimulation, expression of SOCS-3 mRNA is increased in cord blood lymphocytes.
17001312 elevated expression of SOCS genes is a specific lesion of breast-cancer cells that may confer resistance to proinflammatory cytokines and trophic factors, by shutting down STAT1/STAT5 signaling that mediate essential functions in the mammary gland
16943387 The increase in mRNA for SOCS-3, which correlates with elevated levels of SOCS protein and positive immunostaining in M. avium/HIV-1 co-infected tissues.
16920065 Decreased SOCS3 expression in obese adipose tissue may reflect a defective leptin signaling pathway.
16914720 These data argue for the existence of a novel cAMP/Epac/Rap1/SOCS-3 pathway for limiting IL-6 receptor signaling in Endothelial Cells and illuminate a new mechanism by which cAMP may mediate its potent anti-inflammatory effects.
16831601 Deletion of the SOCS3 gene in hepatocytes promotes the activation of STAT3, resistance to apoptosis, and an acceleration of proliferation, resulting in enhanced hepatitis-induced hepatocarcinogenesis.
16822822 Data demonstrate that SOCS3 inhibits leptin activation of AMPK and suggest this impairment of leptin signaling in skeletal muscle may contribute to the aberrant regulation of fatty acid metabolism observed in obesity.
16805839 Our data also show that SOCS3 promoted maintenance of neural stem cells
16709613 role for IL-11 via pSTAT3 and SOCS3 in initiating and progressing decidualization
16568091 Able to repress the activity of the Brk non-receptor tyrosine kinase.
16543409 SOCS-3 inhibits IL-1 signal transduction by inhibiting ubiquitination of TRAF6, thus preventing association and activation of TAK1.
16410555 Results suggest a novel interaction between the SOCS1 and SOCS3 proteins and the FGFR3 signaling pathway.
16402267 Observational study of gene-disease association. (HuGE Navigator)
16374465 this study suggests a potential novel function of SOCS-3 in regulating keratinocyte proliferation and differentiation in vitro and during skin repair in vivo.
16210657 Inhibition of function in dominant-negative SOCS3 transgenic mice clearly reduces the severity of allergic conjunctivitis
16055089 estrogen receptor 1 directly regulates human SOCS-3 promoter activity in human breast cancer cells
16007195 loss of SOCS-3 by the associated DNA methylation confers cells advantage in growth and migration
16007169 promoter methylation and subsequent transcript downregulation of SOCS-3 transcripts and, to a much lesser extent, SOCS-1 are involved in the multistep carcinogenesis of head and neck squamous cell carcinoma
15939448 The induction of SOCS3 by HSV-1 occurs via STAT3 activation immediately after HSV-1 infection.
15629435 SOCS3/CIS3 regulates hepatocyte growth factor-induced keratinocyte migration by inhibiting signal transducer and activator of transcription 3 phosphorylation
15618960 SOCS-3 is not a tumour suppressor but rather a protector of tumour cells.
15607366 The SOCS3 mRNA expression in bone marrow cells from CML patients who responded well to IFN-alpha therapy was significantly lower than that in cells from healthy volunteers and patients who were resistant to IFN-alpha therapy.
15589317 The insertion of amino acid exchanges into the kinase inhibitory regions of SOCS-3 demonstrated a requirement of these domains for a proper inhibitory function.
15385932 overexpression of suppressor of cytokine signaling 3 is associated with anaplastic large cell lymphoma
15361843 SOCS1 and SOCS2 but not SOCS3 suppressed the growth of ovarian and breast cancer cells.
15331532 SOCS-3 expression in human skeletal muscle in vivo is not related to insulin resistance in the presence of elevated IL-6 concentrations suggesting that cytokine action could differ in type 2 diabetic patients and nondiabetic obese subjects.
15308667 interleukin-1beta regulates interleukin-6-induced suppressor of cytokine signaling 3 expression
15300962 Leptin resembles immune molecules called cytokines, which another protein, Socs3, inhibits. Colleagues wondered whether Socs3 also suppresses leptin and promotes resistance to the hormone.
15249995 Observational study of gene-disease association. (HuGE Navigator)
15249995 Homozygosity for the A-allele of the C -920-->A promoter polymorphism of the SOCS3 gene may be associated with increased whole-body insulin sensitivity.
15240148 Our results demonstrate that SOCS-1 and SOCS-3 proteins inhibit IFN-alpha-induced activation of the Jak-STAT pathway and expression of the antiviral proteins 2',5'-OAS and MxA.
15217536 Frequent hypermethylation of the functional SOCS-3 promoter correlates with its transcription silencing in NSCLC cell lines and primary lung cancer tissue samples; methylation silencing of SOCS-3 may be used as a marker for early detection of NSCLC
15163721 rapidly induced in amnion FL cells in HSV-1 infection and appears to be mainly responsible for suppression of IFN signaling and IFN production during the HSV-1 infection.
14617776 hypermethylation in CpG islands of the functional SOCS-3 promoter that correlates with its transcription silencing in primary lung cancer tissue samples
12847520 These data indicate that SOCS-3 has an important role in regulating the onset and maintenance of T(H)2-mediated allergic immune disease.
12783885 acceleration of degradation by tyrosine phosphorylation
12688541 SOCS-3 plays an important role in the suppression of cytokine signaling by GH in down-regulating the acute phase response after injury.
12654831 induction of SOCS3 by Leishmania donovani provides a potent inhibitory mechanism by which intracellular microorganisms may suppress macrophage activation and interfere with the host immune response
12626585 Data showing that SOCS3 is not recruited to phosphotyrosine motifs of the IL-10 receptor complex suggest that IL-10 signaling is less sensitive than IL-6 signaling to inhibition by SOCS3.
12565872 Results describe the cloning and characterization of the promoter region of the human SOCS-3 gene.
12560330 SOCS-3 may have a role in IL-6-mediated insulin resistance in liver
12459551 translational control plays an important role in stabilization and function of SOCS3
12403768 These data suggest, that there are two, largely distinct modes of negative regulation of gp130 activity, despite the fact that both SOCS3 and SHP2 are recruited to the same site within gp130.
12351404 chronic expression confers resistance to IFN-alpha in chronic myelogenous leukemia cells
12198248 SOCS-3 is a major regulator of growth hormone signaling in insulin-producing cells
12027890 evidence for pY429pY431 being a new high affinity binding site for SOCS-3 on the EpoR
11727828 active MKK6 in HepG2 cells enhanced basal activity or IL-6-induced transcriptional activation of a SOCS3 promoter

AA Sequence

MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLI      1 - 70
RDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFPSPP     71 - 140
TEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQL    141 - 210
PGPIREFLDQYDAPL                                                           211 - 225
//

Text Mined References (350)

PMID Year Title
26990535 2016 miR-203 and miR-221 regulate SOCS1 and SOCS3 in essential thrombocythemia.
26812031 Suppressors of cytokine signalling in ankylosing spondylitis and their associations with disease severity, acute-phase reactants and serum cytokines.
26707189 2016 Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer.
26668321 2016 Suppressor of Cytokine Signaling-3 (SOCS-3) Induces Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Expression in Hepatic HepG2 Cell Line.
26485275 2015 The Prognostic Role of SOCS3 and A20 in Human Cholangiocarcinoma.
26464723 2015 Genetic correlation of SOCS3 polymorphisms with infantile asthma: an evidence based on a case-control study.
26447993 2015 SOCS3 Genetic Polymorphism Is Associated With Clinical Features and Prognosis of Hepatocellular Carcinoma Patients Receiving Hepatectomy.
26429311 2015 SOCS3 and its role in associated diseases.
26416445 2015 FXR induces SOCS3 and suppresses hepatocellular carcinoma.
26393582 2015 SOCS3 Methylation Predicts a Poor Prognosis in HBV Infection-Related Hepatocellular Carcinoma.
26306032 2015 Prerequisites for Functional Interleukin 31 Signaling and Its Feedback Regulation by Suppressor of Cytokine Signaling 3 (SOCS3).
26261631 2015 Suppressor of cytokine signaling 3 A+930-->G (rs4969168) polymorphism is associated with apolipoprotein A1 and low-density lipoprotein cholesterol.
26252772 2015 Promotion of Erythropoietic Differentiation in Hematopoietic Stem Cells by SOCS3 Knock-Down.
26246577 2015 Suppressor of Cytokine Signaling 3 Is an Inducible Host Factor That Regulates Virus Egress during Ebola Virus Infection.
26178755 2015 Role of SOCS3 in the Jak/stat3 pathway in the human placenta: different mechanisms for preterm and term labor.
26072679 2015 Suppressor of Cytokine Signaling 3 Expression Induced by Varicella-Zoster Virus Infection Results in the Modulation of Virus Replication.
26047583 2015 Down-regulation of hsa-miR-1264 contributes to DNMT1-mediated silencing of SOCS3.
25939384 2015 SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity.
25849377 2015 Suppressor of cytokine signaling (SOCS) genes are silenced by DNA hypermethylation and histone deacetylation and regulate response to radiotherapy in cervical cancer cells.
25847945 2015 Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling.
25840690 2015 miR-30 overexpression promotes glioma stem cells by regulating Jak/STAT3 signaling pathway.
25827060 2015 Molecular mechanism of ER stress-induced gene expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in macrophages.
25770161 2015 Genetic variations in the SOCS3 gene in patients with Graves' ophthalmopathy.
25764157 2015 SOCS3 silencing attenuates eosinophil functions in asthma patients.
25744243 2015 Enhanced expression of suppresser of cytokine signaling 3 inhibits the IL-6-induced epithelial-to-mesenchymal transition and cholangiocarcinoma cell metastasis.
25730073 2015 Relationship between polymorphism of SOCS-3 and dyslipidemia in China Xinjiang Uygur.
25695729 2015 SOCS3 blocks HIF-1? expression to inhibit proliferation and angiogenesis of human small cell lung cancer by downregulating activation of Akt, but not STAT3.
25689935 2015 Helicobacter pylori infection causes hepatic insulin resistance by the c-Jun/miR-203/SOCS3 signaling pathway.
25648699 2015 Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells.
25640370 2015 Significance of suppressor of cytokine signaling-3 expression in bladder urothelial carcinoma in relation to proinflammatory cytokines and tumor histopathological grading.
25545374 2015 High suppressor of cytokine signaling-3 expression impairs STAT3-dependent protective effects of interleukin-22 in ulcerative colitis in remission.
25458989 2014 SOCS3 and STAT3, major controllers of the outcome of infection with Mycobacterium tuberculosis.
25420583 2014 Construction and in vitro evaluation of a recombinant live attenuated PRRSV expressing GM-CSF.
25416956 2014 A proteome-scale map of the human interactome network.
25377316 2015 Intestinal epithelial suppressor of cytokine signaling 3 enhances microbial-induced inflammatory tumor necrosis factor-?, contributing to epithelial barrier dysfunction.
25286386 2015 Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer's disease brains and human microglia.
25283858 2014 Hepatitis C virus infection in vitro triggers endoplasmic reticulum stress and downregulates insulin receptor substrates 1 and 2 through upregulation of cytokine signaling suppressor 3.
25283845 2015 Transcriptomic profiling of human choriodecidua during term labor: inflammation as a key driver of labor.
25261987 2015 Low expression of SOCS-1 and SOCS-3 is a poor prognostic indicator for gastric cancer patients.
25207681 2014 Differential expression of suppressor of cytokine signalling proteins in Behçet's disease.
25203322 2014 PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis.
25132761 2014 Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C.
25125049 2014 Expression of suppressor of cytokine signaling 3 in cerebrospinal fluid after subarachnoid hemorrhage.
25034082 2014 Lack of association between suppressor of cytokine signaling-3 gene polymorphism and susceptibility and curve severity of adolescent idiopathic scoliosis.
25019494 2014 MiR-221 accentuates IFN?s anti-HCV effect by downregulating SOCS1 and SOCS3.
24996521 2014 SOCS3 methylation in synergy with Reg3A overexpression promotes cell growth in pancreatic cancer.
24969884 2014 Silencing of suppressor of cytokine signaling-3 due to methylation results in phosphorylation of STAT3 in imatinib resistant BCR-ABL positive chronic myeloid leukemia cells.
24951315 2014 Quantitative analysis of the suppressors of cytokine signaling 1 and 3 in peripheral blood leukocytes of patients with multiple sclerosis.
24939297 2014 SOCS3 expression correlates with severity of inflammation in mouse hepatitis virus strain 3-induced acute liver failure and HBV-ACLF.
24932998 2014 JAK2, STAT3 and SOCS3 gene expression in women with and without breast cancer.
24931262 2014 Serum levels of suppressor of cytokine signaling 3 and signal transducer and activator of transcription 3 in childhood atopic dermatitis.
24883303 2014 Immunohistochemical analysis of IL-6, IL-8/CXCR2 axis, ?Tyr p-STAT-3, and SOCS-3 in lymph nodes from patients with chronic lymphocytic leukemia: correlation between microvascular characteristics and prognostic significance.
24833710 2014 Cannabinoid-induced autophagy regulates suppressor of cytokine signaling-3 in intestinal epithelium.
24827536 2014 Dysregulation of the suppressor of cytokine signalling 3-signal transducer and activator of transcription-3 pathway in the aetiopathogenesis of Sjögren's syndrome.
24762139 2015 What is the impact of SOCS3, IL-35 and IL17 in immune pathogenesis of recurrent pregnancy loss?
24728074 2014 Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.
24711032 2014 [Association of SOCS3 gene polymorphisms with insulin resistance in Xinjiang Uygur population].
24659790 2014 Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-? responses.
24636575 2014 Correlation between the suppressor of cytokine signaling-1 and 3 and hepatitis B virus: possible roles in the resistance to interferon treatment.
24633048 2014 SOCS3 promoter hypermethylation is a favorable prognosticator and a novel indicator for G-CIMP-positive GBM patients.
24631457 2014 The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs.
24607843 2014 Survival in patients with high-risk prostate cancer is predicted by miR-221, which regulates proliferation, apoptosis, and invasion of prostate cancer cells by inhibiting IRF2 and SOCS3.
24595859 2014 SOCS signaling in autoimmune diseases: molecular mechanisms and therapeutic implications.
24593195 2014 The role of CXC-chemokine receptor CXCR2 and suppressor of cytokine signaling-3 (SOCS-3) in renal cell carcinoma.
24584041 2014 Progression of clinical tuberculosis is associated with a Th2 immune response signature in combination with elevated levels of SOCS3.
24531711 2015 SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model.
24491408 2014 MicroRNA let-7 downregulates STAT3 phosphorylation in pancreatic cancer cells by increasing SOCS3 expression.
24476004 2014 Loss of suppressors of cytokine signaling 3 promotes aggressiveness in hepatocellular carcinoma.
24414258 2014 Nox2/ROS-dependent human antigen R translocation contributes to TNF-?-induced SOCS-3 expression in human tracheal smooth muscle cells.
24354892 2014 Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.
24212839 2013 Myxovirus resistance, osteopontin and suppressor of cytokine signaling 3 polymorphisms predict hepatitis C virus therapy response in an admixed patient population: comparison with IL28B.
24131863 2013 Methylation profiling of SOCS1, SOCS2, SOCS3, CISH and SHP1 in Philadelphia-negative myeloproliferative neoplasm.
24088176 2014 A critical role for suppressor of cytokine signalling 3 in promoting M1 macrophage activation and function in vitro and in vivo.
24084073 2014 Suppressor of cytokine signaling 3 expression is diminished in sinonasal tissues from patients with chronic rhinosinusitis with nasal polyps.
23910692 2013 Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3.
23900445 2014 Genetic association analysis of 30 genes related to obesity in a European American population.
23894411 2013 miR-19a: an effective regulator of SOCS3 and enhancer of JAK-STAT signalling.
23824571 2013 Lymph node metastasis is mediated by suppressor of cytokine signaling-3 in gastric cancer.
23816468 2013 Angiotensin-converting enzyme 2 attenuates oxidative stress and VSMC proliferation via the JAK2/STAT3/SOCS3 and profilin-1/MAPK signaling pathways.
23803735 2013 Socs3 induction by PPAR? restrains cancer-promoting inflammation.
23782265 2013 Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.
23720494 2013 Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
23686487 2013 SOCS3 regulates BAFF in human enterocytes under ribosomal stress.
23553658 2013 SOCS-1/3 participation in FGF-2 signaling to modulate RANK ligand expression in paget's disease of bone.
23545584 2013 Multiple roles of SOCS proteins: differential expression of SOCS1 and SOCS3 in atherosclerosis.
23490372 2013 Association of suppressor of cytokine signalling 3 polymorphisms with insulin resistance in patients with chronic hepatitis C.
23472246 2013 The role of hepatic expression of STAT1, SOCS3 and PIAS1 in the response of chronic hepatitis C patients to therapy.
23454976 2013 SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition.
23432547 2013 Gene methylation and silencing of SOCS3 in mantle cell lymphoma.
23430957 2013 Pure curcumin increases the expression of SOCS1 and SOCS3 in myeloproliferative neoplasms through suppressing class I histone deacetylases.
23430705 2013 Interference of suppressor of cytokine signaling 3 promotes epithelial-mesenchymal transition in MHCC97H cells.
23392112 2013 Elevated SOCS3 and altered IL-6 signaling is associated with age-related human muscle stem cell dysfunction.
23375208 2013 Chronic rhinosinusitis with polyps and without polyps is associated with increased expression of suppressors of cytokine signaling 1 and 3.
23360921 2013 Survival is associated with genetic variation in inflammatory pathway genes among patients with resected and unresected pancreatic cancer.
23335796 2013 SOCS3 promotor hypermethylation and STAT3-NF-?B interaction downregulate SOCS3 expression in human coronary artery smooth muscle cells.
23320781 2013 Expression of M. tuberculosis-induced suppressor of cytokine signaling (SOCS) 1, SOCS3, FoxP3 and secretion of IL-6 associates with differing clinical severity of tuberculosis.
23302305 2012 [Expression of SOCS3 and Pyk2 and their correlation in non-small cell lung cancer].
23274199 2013 Humanised antihuman IL-6R antibody with interferon inhibits renal cell carcinoma cell growth in vitro and in vivo through suppressed SOCS3 expression.
23229770 2013 Misregulation of suppressors of cytokine signaling in eosinophilic esophagitis.
23226414 2012 Protective role of STAT3 in NMDA and glutamate-induced neuronal death: negative regulatory effect of SOCS3.
23206599 2012 Neuron-intrinsic inhibitors of axon regeneration: PTEN and SOCS3.
23185530 2012 Altered gene expression pattern in peripheral blood mononuclear cells in patients with acute myocardial infarction.
23164156 2013 Intrahepatic mRNA levels of SOCS1 and SOCS3 are associated with cirrhosis but do not predict virological response to therapy in chronic hepatitis C.
23154639 2012 STAT1, STAT6 and adenosine 3',5'-cyclic monophosphate (cAMP) signaling drive SOCS3 expression in inactive ulcerative colitis.
23152563 2012 Suppressors of cytokine signaling promote Fas-induced apoptosis through downregulation of NF-?B and mitochondrial Bfl-1 in leukemic T cells.
23133602 2012 Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants.
23111066 2013 Histone deacetylases inhibitor sodium butyrate inhibits JAK2/STAT signaling through upregulation of SOCS1 and SOCS3 mediated by HDAC8 inhibition in myeloproliferative neoplasms.
23108375 2013 SOCS-3 is downregulated in progressive CKD patients and regulates proliferation in human renal proximal tubule cells in a STAT1/3 independent manner.
23046072 2012 Mutational screening of the SOCS3 gene promoter in metastatic colorectal cancer patients.
23033269 2012 SOCS3 promotes interleukin-17 expression of human T cells.
23030674 2013 Expression of suppressor of cytokine signalling 3 (SOCS3) in human bladder epithelial cells infected with uropathogenic Escherichia coli.
23028842 2012 Loss of expression and function of SOCS3 is an early event in HNSCC: altered subcellular localization as a possible mechanism involved in proliferation, migration and invasion.
23019338 2012 Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components.
22957141 2012 Silencing of microRNA-122 enhances interferon-? signaling in the liver through regulating SOCS3 promoter methylation.
22951153 2013 Decreased interferon-? and interferon-? production in obesity and expression of suppressor of cytokine signaling.
22925925 2012 SOCS3 deficiency promotes M1 macrophage polarization and inflammation.
22848642 2012 Monocyte chemoattractant protein-1 secreted by decidual stromal cells inhibits NK cells cytotoxicity by up-regulating expression of SOCS3.
22820139 Clinical significance of suppressor of cytokines signalling-3 mRNA expression from patients with non-Hodgkin lymphoma under chemotherapy.
22787435 2012 A requirement for SOCS-1 and SOCS-3 phosphorylation in Bcr-Abl-induced tumorigenesis.
22768656 2012 Expression of SOCS1, SOCS2, and SOCS3 in growth hormone-stimulated skin fibroblasts from children with idiopathic short stature.
22745793 2012 Toll-like receptor 3 and suppressor of cytokine signaling proteins regulate CXCR4 and CXCR7 expression in bone marrow-derived human multipotent stromal cells.
22739986 2012 Anti-apoptotic effects of suppressor of cytokine signaling 3 and 1 in psoriasis.
22739025 2012 IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer.
22613986 2012 Angiotensin II induces angiogenic factors production partly via AT1/JAK2/STAT3/SOCS3 signaling pathway in MHCC97H cells.
22591635 2012 SOCS3 in immune regulation of inflammatory bowel disease and inflammatory bowel disease-related cancer.
22587677 2012 The expression of suppressor of cytokine signaling 1 and 3 in fat and placental tissue from women with gestational diabetes.
22576756 2012 Enhanced suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function.
22575502 2012 A novel pro-inflammatory mechanism of action of resistin in human endothelial cells: up-regulation of SOCS3 expression through STAT3 activation.
22574771 2012 The biology and mechanism of action of suppressor of cytokine signaling 3.
22560881 2012 FXR ligands protect against hepatocellular inflammation via SOCS3 induction.
22547065 2012 Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.
22535619 2013 Increased suppressor of cytokine signaling-3 expression predicts mucosal relapse in ulcerative colitis.
22532676 2012 Kaposi's sarcoma-associated herpesvirus inhibits expression and function of endothelial cell major histocompatibility complex class II via suppressor of cytokine signaling 3.
22488585 2013 Alterations of negative regulators of cytokine signalling in immunodeficiency-related non-Hodgkin lymphoma.
22487676 2012 Expression of SOCS1 and SOCS3 is altered in the nasal mucosa of patients with mild and moderate/severe persistent allergic rhinitis.
22425648 2012 Suppressor of cytokine signaling 3 in the human hypothalamus.
22342841 2012 Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity.
22311708 2012 Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors.
22294695 2012 Human primary keratinocytes show restricted ability to up-regulate suppressor of cytokine signaling (SOCS)3 protein compared with autologous macrophages.
22266116 2012 TNF? and SOCS3 regulate IRS-1 to increase retinal endothelial cell apoptosis.
22260693 2012 Unbiased identification of substrates for the Epac1-inducible E3 ubiquitin ligase component SOCS-3.
22093833 2011 Role of suppressor of cytokine signaling 3 in lipid metabolism: analysis based on a phage-display human liver cDNA library.
22084247 2012 CUEDC2 (CUE domain-containing 2) and SOCS3 (suppressors of cytokine signaling 3) cooperate to negatively regulate Janus kinase 1/signal transducers and activators of transcription 3 signaling.
22075701 2011 SOCS3 deletion in B cells alters cytokine responses and germinal center output.
21934357 2011 Methylation-associated dysregulation of the suppressor of cytokine signaling-3 gene in multiple myeloma.
21898505 2012 Glucocorticoids increase interleukin-6-dependent gene induction by interfering with the expression of the suppressor of cytokine signaling 3 feedback inhibitor.
21892197 2011 Association of two polymorphisms within and near SOCS3 gene with obesity in three nationalities in Xinjiang province of China.
21876460 2011 Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in human cutaneous melanoma.
21765854 2011 Suppressors of cytokine signaling 3 expression in eosinophils: regulation by PGE? and Th2 cytokines.
21734367 2011 Suppressors of cytokine signaling inhibit tubular epithelial cell-myofibroblast transdifferentiation.
21590492 2011 SOCS3 promoter methylation is mutually exclusive to EGFR amplification in gliomas and promotes glioma cell invasion through STAT3 and FAK activation.
21547863 2011 Training, leptin receptors and SOCS3 in human muscle.
21545585 2011 Lactobacillus rhamnosus GG and Streptococcus thermophilus induce suppressor of cytokine signalling 3 (SOCS3) gene expression directly and indirectly via interleukin-10 in human primary macrophages.
21490101 2011 Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 91.
21481788 2011 Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.
21478033 2011 Impact of SOCS3 overexpression on human skeletal muscle development in vitro.
21451109 2011 The PPE18 protein of Mycobacterium tuberculosis inhibits NF-?B/rel-mediated proinflammatory cytokine production by upregulating and phosphorylating suppressor of cytokine signaling 3 protein.
21385272 2011 Signal transducer and activator of transcription 3 (STAT3) and Suppressor of Cytokine Signaling (SOCS3) balance controls cytotoxicity and IL-10 expression in decidual-like natural killer cell line NK-92.
21360047 2011 Suppressor of cytokine signalling protein SOCS3 expression is increased at sites of acute and chronic inflammation.
21354254 2011 Hypoxia-induced SOCS3 is limiting STAT3 phosphorylation and NF-?B activation in congenital heart disease.
21337543 2011 HIV interferes with SOCS-1 and -3 expression levels driving immune activation.
21325601 2011 Serum amyloid A overrides Treg anergy via monocyte-dependent and Treg-intrinsic, SOCS3-associated pathways.
21308719 2011 SOCS-3 antagonizes pro-apoptotic effects of TRAIL and resveratrol in prostate cancer cells.
21275162 2010 [Effects of Huatan Tongluo Granule on SOCS-3 and TNF-alpha expressions in patients with acute cerebral infarction].
21263153 2011 Sox6 enhances erythroid differentiation in human erythroid progenitors.
21190606 2010 [The expression of suppressor of cytokine signaling-1/3 in renal tubular epithelial cells induced by high glucose].
21173340 2011 Elevated maternal soluble Gp130 and IL-6 levels and reduced Gp130 and SOCS-3 expressions in women complicated with preeclampsia.
21042758 2010 Adenovirus-mediated SOCS3 gene transfer inhibits the growth and enhances the radiosensitivity of human non-small cell lung cancer cells.
21029588 2010 [Expression of suppressor of cytokine signaling 3 and its significance in human placenta with pregnant intrahepatic cholestasis].
20934424 2010 Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11.
20840058 2010 Effect of anaphylactic shock on suppressors of cytokine signaling.
20717995 2011 Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior.
20690084 2010 No association of polymorphisms in the suppressor of cytokine signaling (SOCS)-3 with rheumatoid arthritis in the Chinese Han population.
20689596 2010 Epstein-Barr virus interferes with the amplification of IFNalpha secretion by activating suppressor of cytokine signaling 3 in primary human monocytes.
20673263 2011 Suppressor of cytokine signaling-3 is affected in T-cells from tuberculosisTB patients.
20631305 2010 Suppressor of cytokine signaling 3 inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages.
20588308 2010 Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
20504769 2010 Oral administration of high molecular weight hyaluronan (900 kDa) controls immune system via Toll-like receptor 4 in the intestinal epithelium.
20503287 2010 Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
20484656 2010 IFN gamma-dependent SOCS3 expression inhibits IL-6-induced STAT3 phosphorylation and differentially affects IL-6 mediated transcriptional responses in endothelial cells.
20478455 2010 Pro-inflammatory cytokines induce suppressor of cytokine signaling-3 in human periodontal ligament cells.
20468064 2010 Association study of 182 candidate genes in anorexia nervosa.
20438785 2010 Polymorphisms in innate immunity genes and risk of childhood leukemia.
20433750 2010 Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer.
20406964 2010 Risk of meningioma and common variation in genes related to innate immunity.
20398276 2010 Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells.
20375166 2010 Suppressor of cytokine signaling 3 suppresses hepatitis C virus replication in an mTOR-dependent manner.
20372794 2010 Enforced SOCS1 and SOCS3 expression attenuates Lck-mediated cellular transformation.
20351777 2010 Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3.
20335309 2010 SOCS-3 antagonises the proliferative and migratory effects of fibroblast growth factor-2 in prostate cancer by inhibition of p44/p42 MAPK signalling.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
20231901 2010 Upregulation of SOCS-3 and PIAS-3 impairs IL-12-mediated interferon-gamma response in CD56 T cells in HCV-infected heroin users.
20155426 2010 Loss of SOCS3 expression is associated with an increased risk of recurrent disease in breast carcinoma.
20137421 2009 [Expression of suppressor of cytokine signaling in peripheral blood monocular cells of patients with Vogt-Koyanagi-Harada disease].
20136974 2010 Anti-inflammatory actions of probiotics through activating suppressor of cytokine signaling (SOCS) expression and signaling in Helicobacter pylori infection: a novel mechanism.
20130595 2010 Deficient SOCS3 and SHP-1 expression in psoriatic T cells.
20067961 2010 Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3.
20005910 2010 Hepatitis B virus overexpresses suppressor of cytokine signaling-3 (SOCS3) thereby contributing to severity of inflammation in the liver.
19951849 2009 Expression of signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 in urothelial carcinoma.
19913854 2010 Dysregulation of sterol regulatory element binding protein-1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling-3 and signal transducer and activator of transcription-1 signaling.
19803812 2009 SOCS3 and IRS-1 gene expression differs between genotype 1 and genotype 2 hepatitis C virus-infected HepG2 cells.
19737863 2009 Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis.
19643162 2009 Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.
19634073 2009 [Androgens stimulate the expression of SOCS-3 and inhibits their effect on proliferation and secretion].
19617629 2009 Adiponectin inhibits pro-inflammatory signaling in human macrophages independent of interleukin-10.
19595407 2009 RSV replication is attenuated by counteracting expression of the suppressor of cytokine signaling (SOCS) molecules.
19592492 2009 Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling.
19543316 2009 SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.
19524687 2009 Restoration of SOCS3 suppresses human lung adenocarcinoma cell growth by downregulating activation of Erk1/2, Akt apart from STAT3.
19423540 2009 Common variation in genes related to innate immunity and risk of adult glioma.
19258923 2009 Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
19231005 2009 Hepatic SOCS3 expression is strongly associated with non-response to therapy and race in HCV and HCV/HIV infection.
19229050 2009 SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases.
19225535 2009 SOCS3 inhibits TPO-stimulated, but not spontaneous, megakaryocytic growth in primary myelofibrosis.
19164812 2009 Suppressors of cytokine signaling modulate JAK/STAT-mediated cell responses during atherosclerosis.
19129540 2009 Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.
19115200 2009 SOCS3 as a tumor suppressor in breast cancer cells, and its regulation by PRL.
19083014 2009 Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study.
19077438 2009 Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations.
19052638 2008 Lack of association between the tagging SNP A+930-->G of SOCS3 and type 2 diabetes mellitus: meta-analysis of four independent study populations.
19036437 2009 Over-expression of SOCS-3 gene promotes IL-10 production by JEG-3 trophoblast cells.
19027008 2008 The role of microtubule-associated protein 1S in SOCS3 regulation of IL-6 signaling.
18989459 2008 Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression.
18986700 2008 Altered interleukin-6 receptor, IL-6R and gp130, production and expression and decreased SOCS-3 expression in placentas from women with pre-eclampsia.
18971287 2009 CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression.
18952062 2008 Interaction of SOCS3 with NonO attenuates IL-1beta-dependent MUC8 gene expression.
18941624 2008 Gender dimorphism in skeletal muscle leptin receptors, serum leptin and insulin sensitivity.
18820827 2008 The analysis of CIS, SOCS1, SOSC2 and SOCS3 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients.
18815196 2008 Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in myeloproliferative disorders.
18770864 2008 Prognostic relevance of SOCS3 hypermethylation in patients with glioblastoma multiforme.
18752121 2008 SOCS-3 is associated with vascular invasion and overall survival in hepatocellular carcinoma.
18687693 2008 SOCS-3 inhibits E2F/DP-1 transcriptional activity and cell cycle progression via interaction with DP-1.
18660489 2008 Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
18656467 2008 Increased expression of SOCS3 in monocytes and SOCS1 in lymphocytes correlates with progressive loss of renal function and cardiovascular risk factors in chronic kidney disease.
18636124 2008 Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.
18571793 2008 Molecular basis of oncostatin M-induced SOCS-3 expression in astrocytes.
18549612 2008 [Relationship between socs3 mRNA expression and jak2v617f point mutation in bcr-abl negative patients with myelo-proliferative disease].
18538318 2008 SOCS in situ expression in tuberculous lymphadenitis in an endemic area.
18507841 2008 SOCS3 inhibiting migration of A549 cells correlates with PYK2 signaling in vitro.
18440067 2008 Methylation status of SOCS1 and SOCS3 in BCR-ABL negative and JAK2V617F negative chronic myeloproliferative neoplasms.
18414649 2008 Lower expression of TLR2 and SOCS-3 is associated with Schistosoma haematobium infection and with lower risk for allergic reactivity in children living in a rural area in Ghana.
18250407 2008 Cutting edge: innate immune response triggered by influenza A virus is negatively regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-dependent pathway.
18240972 2008 Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation.
18199397 2008 [Study on the relationship between the expression of SOCS-1/3 in the peripheral blood mononuclear cells in patients with multiple organ dysfunction syndrome and their prognosis].
18097573 2008 Decreased expression of SOCS-3 mRNA in breast cancer with lymph node metastasis.
18055217 2008 SOCS3 suppresses AP-1 transcriptional activity in neuroblastoma cells through inhibition of c-Jun N-terminal kinase.
18045952 2007 Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion.
17935223 2008 Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma.
17895321 2007 Association of serum and follicular fluid leptin concentrations with granulosa cell phosphorylated signal transducer and activator of transcription 3 expression in fertile patients with polycystic ovarian syndrome.
17881539 2008 Elevated expression and polymorphisms of SOCS3 influence patient response to antiviral therapy in chronic hepatitis C.
17703412 2007 Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
17668875 2007 Suppressor of cytokine signaling 3 (SOCS3) expression and hepatitis C virus-related chronic hepatitis: Insulin resistance and response to antiviral therapy.
17636039 2007 Characterization of the SOCS3 promoter response to prostaglandin E2 in T47D cells.
17605868 2007 [Mechanism underlying IL-2 inhibition on T cell specific immune response].
17589943 2007 Clinical significance of mucosal suppressors of cytokine signaling 3 expression in ulcerative colitis.
17530721 2007 Specific gene expression profiles in systemic juvenile idiopathic arthritis.
17445271 2007 Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3 gene in extremely obese children and adolescents.
17438093 2007 Reciprocal regulation of SOCS 1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme.
17374732 2007 Constitutive suppressor of cytokine signaling 3 expression confers a growth advantage to a human melanoma cell line.
17363902 2007 Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor.
17325857 2007 Overexpression of SOCS-2 and SOCS-3 genes reverses erythroid overgrowth and IGF-I hypersensitivity of primary polycythemia vera (PV) cells.
17297444 2007 Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon.
17273770 2007 Methylation status of the SOCS3 gene in human malignant melanomas.
17264307 2007 Molecular mechanisms involved in interleukin-4-induced human neutrophils: expression and regulation of suppressor of cytokine signaling.
17241887 2007 Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing.
17148681 2006 Suppressor of cytokine signaling-3 antagonizes cAMP effects on proliferation and apoptosis and is expressed in human prostate cancer.
17138568 2007 SOCS3 targets Siglec 7 for proteasomal degradation and blocks Siglec 7-mediated responses.
17083795 2006 [Expression and role of TLR and SOCS mRNA in newborn infants].
17001312 2007 Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals.
16943387 2006 Mycobacterium avium-induced SOCS contributes to resistance to IFN-gamma-mediated mycobactericidal activity in human macrophages.
16920065 2006 Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women.
16914720 2006 Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells.
16831601 2006 Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.
16822822 2006 The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans.
16805839 2006 Overexpression of SOCS3 inhibits astrogliogenesis and promotes maintenance of neural stem cells.
16709613 2006 Interleukin 11 signaling components signal transducer and activator of transcription 3 (STAT3) and suppressor of cytokine signaling 3 (SOCS3) regulate human endometrial stromal cell differentiation.
16685656 2006 Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis.
16568091 2006 Identification of STAT3 as a specific substrate of breast tumor kinase.
16543409 2006 Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex.
16410555 2006 Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling.
16402267 2006 Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins.
16381901 2006 The LIFEdb database in 2006.
16374465 2006 The suppressor of cytokine signaling-3 is upregulated in impaired skin repair: implications for keratinocyte proliferation.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16210657 2005 The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model.
16055089 2005 Estrogen receptor-alpha regulates SOCS-3 expression in human breast cancer cells.
16007195 2005 Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma.
16007169 2005 SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition.
15939448 2005 Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 confers efficient viral replication.
15629435 2005 SOCS3/CIS3 negative regulation of STAT3 in HGF-induced keratinocyte migration.
15618960 2005 Constitutive SOCS-3 expression protects T-cell lymphoma against growth inhibition by IFNalpha.
15607366 2005 Expression of SOCS3 mRNA in bone marrow cells from CML patients associated with cytogenetic response to IFN-alpha.
15601820 2004 VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
15589317 2005 SOCS-1 and SOCS-3 inhibit IL-4 and IL-13 induced activation of Eotaxin-3/CCL26 gene expression in HEK293 cells.
15489336 2004 From ORFeome to biology: a functional genomics pipeline.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15385932 2004 Suppressor of cytokine signaling 3 expression in anaplastic large cell lymphoma.
15361843 2004 Differential hypermethylation of SOCS genes in ovarian and breast carcinomas.
15331532 2004 Suppressor of cytokine signaling 3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients.
15308667 2004 Dual function of interleukin-1beta for the regulation of interleukin-6-induced suppressor of cytokine signaling 3 expression.
15300962 2004 Unraveling Socs.
15249995 2004 Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity.
15240148 2004 SOCS-1 and SOCS-3 inhibit IFN-alpha-induced expression of the antiviral proteins 2,5-OAS and MxA.
15217536 2004 Activity of the suppressor of cytokine signaling-3 promoter in human non-small-cell lung cancer.
15163721 2004 Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
15070676 2004 Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation.
14617776 2003 SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer.
14559241 2003 SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit.
12847520 2003 SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses.
12783885 2003 Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation.
12688541 2003 Growth hormone down-regulation of Interleukin-1beta and Interleukin-6 induced acute phase protein gene expression is associated with increased gene expression of suppressor of cytokine signal-3.
12654831 2003 Leishmania donovani-induced expression of suppressor of cytokine signaling 3 in human macrophages: a novel mechanism for intracellular parasite suppression of activation.
12626585 2003 Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3.
12565872 2003 Cloning and characterization of a functional promoter of the human SOCS-3 gene.
12560330 2003 Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12459551 2003 The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6.
12403768 2003 SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130.
12351404 2002 Constitutive expression of SOCS3 confers resistance to IFN-alpha in chronic myelogenous leukemia cells.
12228220 2002 SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2.
12198248 2002 The effect of suppressor of cytokine signaling 3 on GH signaling in beta-cells.
12182826 2002 Preparation and expression of biologically active prolactin and growth hormone receptors and suppressor of cytokine signaling proteins 1, 2, 3, and 6 tagged with cyan and yellow fluorescent proteins.
12163560 2002 Functional inactivation of CXC chemokine receptor 4-mediated responses through SOCS3 up-regulation.
12133942 2002 Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction.
12076535 2002 The SOCS box: a tale of destruction and degradation.
12070153 2002 Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation.
12027890 2002 A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor.
11970967 2002 Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp.
11889171 2002 Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor.
11867182 2002 Activation of signal transducer and activator transcription 3 and expression of suppressor of cytokine signal 1 during liver regeneration in rats.
11786421 2002 Regulation of signal transducer and activator of transcription and suppressor of cytokine-signaling gene expression in the brain of mice with astrocyte-targeted production of interleukin-12 or experimental autoimmune encephalomyelitis.
11727828 2001 The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription.
11713228 2001 Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor.
11481489 2001 Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3.
11331873 2001 Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras.
11279517 2001 Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci.
11076863 2000 DNA cloning using in vitro site-specific recombination.
11071852 2000 Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor.
11034314 2000 IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3.
11018044 2000 SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985.
10946280 2000 Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation.
10882725 2000 CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2.
10837055 2000 Negative regulation of cytokine signaling pathways.
10777583 2000 SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130.
10585430 1999 SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms.
10490101 1999 SOCS3 is essential in the regulation of fetal liver erythropoiesis.
10421843 1999 Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain.
10051596 1999 The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
9344848 1997 Cloning and characterization of novel CIS family genes.
9266833 1997 Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.