Property Summary

NCBI Gene PubMed Count 19
PubMed Score 10.24
PubTator Score 9.09

Knowledge Summary


No data available


  Differential Expression (7)

Disease log2 FC p
osteosarcoma 1.642 6.0e-05
juvenile dermatomyositis 1.217 2.3e-09
acute quadriplegic myopathy 1.016 6.2e-05
primary pancreatic ductal adenocarcinoma 1.454 1.6e-03
intraductal papillary-mucinous neoplasm ... 1.200 1.0e-02
ovarian cancer -1.300 6.7e-05
pancreatic cancer 1.100 1.9e-02

Gene RIF (6)

25535984 These results identify SNX6 as a key regulator of lamin A synthesis and incorporation into the nuclear envelope.
25496667 Genome-wide shRNA screening identifies SNX6, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells
20830743 Study observed that SNX6 increases BRMS1-dependent transcriptional repression. Moreover, over-expression of SNX6 was capable of diminishing trans-activation in a dose-dependent manner.
20354142 SNX6 modulates the retrograde trafficking and basal levels of BACE1, thereby regulating BACE1-mediated APP processing and Abeta biogenesis
19935774 These observations indicate that in addition to SNX1/2, SNX6 in association with the dynein/dynactin complex drives the formation and movement of tubular retrograde intermediates.
17148574 SNX5 and SNX6 may constitute functional equivalents of Vps17p in mammalian retromer

AA Sequence


Text Mined References (30)

PMID Year Title
26220253 2015 Retromer: Structure, function, and roles in mammalian disease.
26172538 2015 Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25535984 2014 Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope.
24610942 2014 Isoform 5 of PIPKI? regulates the endosomal trafficking and degradation of E-cadherin.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23936387 2013 A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
23414517 2013 A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23085988 2012 Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22223895 2012 Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-?-acetylation features.
21269460 2011 Initial characterization of the human central proteome.
20830743 2010 Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression.
20354142 2010 Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing.
19935774 2009 The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport.
19619496 2009 The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
18253931 2008 Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17148574 2007 A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer.
17043677 2007 Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12508121 2003 The DNA sequence and analysis of human chromosome 14.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11591366 2001 Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus.
11485546 2001 A large family of endosome-localized proteins related to sorting nexin 1.
11279102 2001 Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases.
11278302 2001 Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone.