Tdark SNX22 Sorting nexin-22

Protein Summary

Description

May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). The protein encoded by this gene is a sorting nexin that is found in the cytoplasm, where it interacts with membrane-bound phosphatidylinositol 3-phosphate. The encoded protein may play a role in intracellular trafficking. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• Q96L94
• Q8WUS9
• Q9H844

Gene Name

• SNX22

Ensembl ID

• ENST00000325881
• ENSP00000323435
• ENSG00000157734
• ENST00000558466
• ENSP00000452692

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.71
tissue sample	0.67
transcription factor	0.57
transcription factor binding site profile	0.54
microRNA	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.43   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 42   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.43   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0