| Tbio | Sorting nexin-13 |
May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas.
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 9.6e-10 |
| osteosarcoma | 7950 | 1.2e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 5.1e-05 |
| Pick disease | 1894 | 7.4e-05 |
| Crohn's disease | 321 | 8.4e-05 |
| medulloblastoma, large-cell | 6241 | 1.1e-04 |
| psoriasis | 6694 | 5.3e-04 |
| ulcerative colitis | 1819 | 8.4e-04 |
| progressive supranuclear palsy | 676 | 6.7e-03 |
| glioblastoma | 5792 | 7.6e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.9e-02 |
| lung cancer | 4740 | 2.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Acrocephalosyndactylia | 17 | 4.112 | 2.1 |
| Learning disability | 17 | 3.295 | 1.6 |
| Brachydactyly | 156 | 3.209 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | -1.200 | 5.1e-05 |
| Crohn's disease | -1.000 | 8.4e-05 |
| glioblastoma | 1.100 | 7.6e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.100 | 1.9e-02 |
| lung cancer | 1.100 | 2.5e-02 |
| medulloblastoma, large-cell | -1.800 | 1.1e-04 |
| osteosarcoma | 3.191 | 1.2e-05 |
| ovarian cancer | -2.500 | 9.6e-10 |
| Pick disease | -1.100 | 7.4e-05 |
| progressive supranuclear palsy | -1.300 | 6.7e-03 |
| psoriasis | -1.200 | 5.3e-04 |
| ulcerative colitis | -1.044 | 8.4e-04 |
MLTEASLSIWGWGSLGIVLFLITFGPFVIFYLTFYILCFVGGGLVVTLLFGKTNSEKYLEQCEHSFLPPT 1 - 70 SPGVPKCLEEMKREARTIKIDRRLTGANIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNA 71 - 140 LIQFATRSKEIDWQPYFTTRIVDDFGTHLRVFRKAQQKITEKDDQVKGTAEDLVDTFFEVEVEMEKEVCR 141 - 210 DLVCTSPKDEEGFLRDLCEVLLYLLLPPGDFQNKIMRYFVREILARGILLPLINQLSDPDYINQYVIWMI 211 - 280 RDSNCNYEAFMNIIKLSDNIGELEAVRDKAAEELQYLRSLDTAGDDINTIKNQINSLLFVKKVCDSRIQR 281 - 350 LQSGKEINTVKLAANFGKLCTVPLDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVL 351 - 420 LSRQRDGKHQTNQTKGLLRAAAVGIYEQYLSEKASPRVTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVY 421 - 490 ELMLRDERFYPSFRQNALYVRMLAELDMLKDPSFRGSDDGDGESFNGSPTGSINLSLDDLSNVSSDDSVQ 491 - 560 LHAYISDTVYADYDPYAVAGVCNDHGKTYALYAITVHRRNLNSEEMWKTYRRYSDFHDFHMRITEQFESL 561 - 630 SSILKLPGKKTFNNMDRDFLEKRKKDLNAYLQLLLAPEMMKASPALAHYVYDFLENKAYSKGKGDFARKM 631 - 700 DTFVNPLRNSMRNVSNAVKSLPDSLAEGMTKMSDNMGKMSERLGQDIKQSFFKVPPLIPKTDSDPEHRRV 701 - 770 SAQLDDNVDDNIPLRVMLLLMDEVFDLKERNQWLRRNIKNLLQQLIRATYGDTINRKIVDHVDWMTSPEQ 771 - 840 VADSVKRFRDAFWPNGILAEAVPCRDKSIRMRTRVAGKTKLLAIMPDELKHIIGAETTRKGILRVFEMFQ 841 - 910 HNQLNRRMVYVFLEGFLETLFPQYKFRELFNKLHSRSKQMQKYKQKLQTTQAPSLQKR 911 - 968 //
