Property Summary

NCBI Gene PubMed Count 28
PubMed Score 8.71
PubTator Score 47.84

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (22)

Disease log2 FC p
astrocytic glioma 1.500 4.7e-03
ependymoma 1.500 1.0e-02
oligodendroglioma 1.200 2.1e-02
osteosarcoma -1.883 4.6e-06
atypical teratoid / rhabdoid tumor 1.400 1.3e-03
glioblastoma 1.600 3.7e-03
acute quadriplegic myopathy 1.366 1.6e-05
adrenocortical carcinoma -1.420 1.5e-02
pancreatic ductal adenocarcinoma liver m... -2.600 6.1e-04
tuberculosis 1.200 6.5e-07
non-small cell lung cancer -1.115 1.4e-08
intraductal papillary-mucinous adenoma (... -1.300 2.9e-02
intraductal papillary-mucinous carcinoma... -1.300 4.4e-02
intraductal papillary-mucinous neoplasm ... -2.000 9.7e-03
lung cancer 2.200 1.1e-05
colon cancer 2.400 5.5e-04
Breast cancer 3.200 2.4e-02
pediatric high grade glioma 1.200 3.4e-03
aldosterone-producing adenoma -1.873 1.2e-02
psoriasis -1.900 3.5e-145
lung carcinoma -1.200 1.3e-07
ovarian cancer 1.700 9.8e-05

Gene RIF (3)

PMID Text
24975899 SNTB1 and MCPH1 are located on chromosome 8, which may be involved in neuroticism, avoidant personality and depression.
22721673 Yeast two hybrid assay identifies the HIV-1 Nef-interacting protein syntrophin
16192269 beta1-syntrophin acts through a class-I PDZ interaction with the C terminus of ABCA1 to regulate the cellular distribution and activity of the transporter

AA Sequence

MAVAAAAAAAGPAGAGGGRAQRSGLLEVLVRDRWHKVLVNLSEDALVLSSEEGAAAYNGIGTATNGSFCR      1 - 70
GAGAGHPGAGGAQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENKMPILIS     71 - 140
KIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPYVKKGSPVSEI    141 - 210
GWETPPPESPRLGGSTSDPPSSQSFSFHRDRKSIPLKMCYVTRSMALADPENRQLEIHSPDAKHTVILRS    211 - 280
KDSATAQAWFSAIHSNVNDLLTRVIAEVREQLGKTGIAGSREIRHLGWLAEKVPGESKKQWKPALVVLTE    281 - 350
KDLLIYDSMPRRKEAWFSPVHTYPLLATRLVHSGPGKGSPQAGVDLSFATRTGTRQGIETHLFRAETSRD    351 - 420
LSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQSPYEKLKMSS    421 - 490
DDGIRMLYLDFGGKDGEIQLDLHSCPKPIVFIIHSFLSAKITRLGLVA                          491 - 538
//

Text Mined References (37)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24975899 2014 Association of microcephalin 1, syntrophin-beta 1, and other genes with automatic thoughts in the Japanese population.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24024966 2013 Genome-wide association study of chronic periodontitis in a general German population.
23933737 2013 Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia.
23406873 2013 A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
21423176 2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ?-Pix in negative regulation of focal adhesion maturation.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.
20889312 2010 A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
20208534 2010 Common variants at 5q22 associate with pediatric eosinophilic esophagitis.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
18468998 2008 Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.
18088087 2008 Phosphoproteome of resting human platelets.
16533813 2006 Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction.
16192292 2006 The potential role of human endogenous retrovirus K10 in the pathogenesis of rheumatoid arthritis: a preliminary study.
16192270 2005 A novel Arabidopsis gene causes Bax-like lethality in Saccharomyces cerevisiae.
16192269 2005 Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15024025 2004 Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12665801 2003 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12136098 2002 NotI flanking sequences: a tool for gene discovery and verification of the human genome.
11352924 2001 Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions.
11168526 2001 Differential targeting of components of the dystrophin complex to the postsynaptic membrane.
11069112 2000 Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex.
10545507 1999 Different dystrophin-like complexes are expressed in neurons and glia.
10212242 1999 Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition.
9482110 1998 The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins.
9412493 1998 Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins.
8576247 1996 The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives.
8183929 1994 Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24.
8119949 1994 Heterogeneity of the 59-kDa dystrophin-associated protein revealed by cDNA cloning and expression.
7844150 1995 Syntrophin binds to an alternatively spliced exon of dystrophin.