1. Home
  2. Targets
  3. nucleic acid binding
  4. RNA binding protein
  5. mRNA processing factor
  6. mRNA splicing factor
  7. U2 small nuclear ribonucleoprotein B''

Tdark U2 small nuclear ribonucleoprotein B''

Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A' protein.

The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 27
PubMed Score 3.02
PubTator Score 1.92

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Disease Target Count P-value
sonic hedgehog group medulloblastoma 467 7.6e-07
lung cancer 4740 4.3e-03
breast carcinoma 1638 3.0e-02

Expression

  Differential Expression (3)

Disease log2 FC p
breast carcinoma 1.100 3.0e-02
lung cancer 1.700 4.3e-03
sonic hedgehog group medulloblastoma 1.200 7.6e-07

Synonym

Accession P08579 B2R7J3 D3DW21 Q9UJD4 U2 snRNP B''
Symbols Msl1
U2B''

Gene

SNRPB2

PANTHER Protein Class (4)

PDB

5O9Z   5XJC   5MQF   1A9N  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (15)

See all...

 GO Function (3)

 GO Component (7)

 GO Process (1)

 Compartment GO Term (40)

See all...

 HCA RNA Cell Line (56)

See all...

Pathway (7)

Protein-protein Interaction (33)

SF3B3   SF3B1   TOE1   GEMIN5   HTATSF1   SF3B2   CWF19L2   ICE2   XAB2   SLC4A1AP   TTC19   SF3A1   SNUPN   PRKRIP1   TGS1   TFIP11   PHAX   SF3A2   CDC40   ICE1   SNRPD2   CHERP   DDX46   CWF19L1   U2SURP   GPATCH11   SNRPA1   RNPC3   SNRPB   AQR   SF3A3   SNRPD1   SF3B5  

Gene RIF (2)

AA Sequence 

MDIRPNHTIYINNMNDKIKKEELKRSLYALFSQFGHVVDIVALKTMKMRGQAFVIFKELGSSTNALRQLQ      1 - 70
GFPFYGKPMRIQYAKTDSDIISKMRGTFADKEKKKEKKKAKTVEQTATTTNKKPGQGTPNSANTQGNSTP     71 - 140
NPQVPDYPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGF    141 - 210
KITPSHAMKITYAKK                                                           211 - 225
//

Text Mined References (31)

PMID Year Title