| Tbio | snRNA-activating protein complex subunit 3 |
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| medulloblastoma, large-cell | 6241 | 2.8e-06 |
| atypical teratoid / rhabdoid tumor | 5112 | 4.4e-06 |
| malignant mesothelioma | 3232 | 1.7e-05 |
| osteosarcoma | 7950 | 4.2e-05 |
| ovarian cancer | 8520 | 1.1e-04 |
| psoriasis | 6694 | 1.2e-04 |
| hepatocellular carcinoma | 547 | 1.4e-04 |
| adult high grade glioma | 3801 | 1.7e-04 |
| Pick disease | 1894 | 2.0e-04 |
| group 4 medulloblastoma | 1855 | 4.6e-04 |
| glioblastoma | 5792 | 9.2e-04 |
| lung cancer | 4740 | 8.0e-03 |
| astrocytic glioma | 2597 | 1.4e-02 |
| ependymoma | 4679 | 1.6e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.100 | 1.7e-04 |
| astrocytic glioma | -1.100 | 1.4e-02 |
| atypical teratoid / rhabdoid tumor | -1.400 | 4.4e-06 |
| ependymoma | 1.300 | 1.6e-02 |
| glioblastoma | -1.700 | 9.2e-04 |
| group 4 medulloblastoma | 1.100 | 4.6e-04 |
| hepatocellular carcinoma | 1.100 | 1.4e-04 |
| lung cancer | 1.400 | 8.0e-03 |
| malignant mesothelioma | -1.300 | 1.7e-05 |
| medulloblastoma, large-cell | -1.600 | 2.8e-06 |
| osteosarcoma | -1.180 | 4.2e-05 |
| ovarian cancer | 1.300 | 1.1e-04 |
| Pick disease | 1.200 | 2.0e-04 |
| psoriasis | -1.900 | 1.2e-04 |
| Accession | Q92966 D3DRI8 Q2VPI6 Q5T285 SNAPc subunit 3 |
| Symbols |
SNAP50 PTFbeta |
MAEGSRGGPTCSGVGGRQDPVSGSGGCNFPEYELPELNTRAFHVGAFGELWRGRLRGAGDLSLREPPASA 1 - 70 LPGSQAADSDREDAAVARDLDCSLEAAAELRAVCGLDKLKCLEDGEDPEVIPENTDLVTLGVRKRFLEHR 71 - 140 EETITIDRACRQETFVYEMESHAIGKKPENSADMIEEGELILSVNILYPVIFHKHKEHKPYQTMLVLGSQ 141 - 210 KLTQLRDSIRCVSDLQIGGEFSNTPDQAPEHISKDLYKSAFFYFEGTFYNDKRYPECRDLSRTIIEWSES 211 - 280 HDRGYGKFQTARMEDFTFNDLCIKLGFPYLYCHQGDCEHVIVITDIRLVHHDDCLDRTLYPLLIKKHWLW 281 - 350 TRKCFVCKMYTARWVTNNDSFAPEDPCFFCDVCFRMLHYDSEGNKLGEFLAYPYVDPGTFN 351 - 411 //
