| Tbio | Clathrin coat assembly protein AP180 |
Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 4.4e-70 |
| oligodendroglioma | 2850 | 9.0e-09 |
| psoriasis | 6694 | 2.5e-07 |
| glioblastoma | 5792 | 7.9e-07 |
| Astrocytoma, Pilocytic | 3081 | 9.6e-07 |
| medulloblastoma, large-cell | 6241 | 1.0e-06 |
| adult high grade glioma | 3801 | 3.7e-06 |
| pituitary cancer | 1972 | 2.2e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 3.6e-05 |
| primitive neuroectodermal tumor | 3035 | 1.6e-04 |
| astrocytic glioma | 2597 | 7.8e-03 |
| Pick disease | 1894 | 1.9e-02 |
| group 3 medulloblastoma | 4104 | 3.0e-02 |
| ependymoma | 4679 | 3.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cataract 8 multiple types | 33 | 4.508 | 2.3 |
| Alzheimer's disease | 658 | 3.024 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -4.100 | 3.7e-06 |
| astrocytic glioma | -1.900 | 7.8e-03 |
| Astrocytoma, Pilocytic | -1.900 | 9.6e-07 |
| atypical teratoid / rhabdoid tumor | -3.800 | 3.6e-05 |
| ependymoma | -2.900 | 3.6e-02 |
| glioblastoma | -3.800 | 7.9e-07 |
| group 3 medulloblastoma | -1.300 | 3.0e-02 |
| lung carcinoma | 4.600 | 4.4e-70 |
| medulloblastoma, large-cell | -3.600 | 1.0e-06 |
| oligodendroglioma | -1.900 | 9.0e-09 |
| Pick disease | -1.900 | 1.9e-02 |
| pituitary cancer | 1.100 | 2.2e-05 |
| primitive neuroectodermal tumor | -1.800 | 1.6e-04 |
| psoriasis | -1.200 | 2.5e-07 |
MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNS 1 - 70 SWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQ 71 - 140 MAFDFARVKKGADGVMRTMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFAC 141 - 210 YNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQ 211 - 280 HLNTLEGKKPGNNEGSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDLFATASAAVPVSTSKPSSDLL 281 - 350 DLQPDFSSGGAAAAAAPAPPPPAGGATAWGDLLGEDSLAALSSVPSEAQISDPFAPEPTPPTTTAEIATA 351 - 420 SASASTTTTVTAVTAEVDLFGDAFAASPGEAPAASEGAAAPATPTPVAAALDACSGNDPFAPSEGSAEAA 421 - 490 PELDLFAMKPPETSVPVVTPTASTAPPVPATAPSPAPAVAAAAAATTAATAAATTTTTTSAATATTAPPA 491 - 560 LDIFGDLFESTPEVAAAPKPDAAPSIDLFSTDAFSSPPQGASPVPESSLTADLLSVDAFAAPSPATTASP 561 - 630 AKVDSSGVIDLFGDAFGSSASEPQPASQAASSSSASADLLAGFGGSFMAPSPSPVTPAQNNLLQPNFEAA 631 - 700 FGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPAGQPAPVSMVPPSPAMAASKALGSDLDSSLASLVGNLGI 701 - 770 SGTTTKKGDLQWNAGEKKLTGGANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGF 771 - 840 GMPPAGTGMPMMPQQPVMFAQPMMRPPFGAAAVPGTQLSPSPTPASQSPKKPPAKDPLADLNIKDFL 841 - 907 //
