SNAP91
Clathrin coat assembly protein AP180
Protein Summary
Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity).
- ENST00000369694
- ENSP00000358708
- ENSG00000065609
- ENST00000439399
- ENSP00000400459
- ENST00000520213
- ENSP00000428026
- ENST00000520302
- ENSP00000428511
- ENST00000521743
- ENSP00000428215
- KIAA0656
- CALM
- AP180
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.94 | ||
PubMedID | 0.68 | ||
cellular component | 0.64 | ||
tissue sample | 0.59 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 127.62 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 97 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 127.62 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 97 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0