Property Summary

NCBI Gene PubMed Count 19
PubMed Score 835.71
PubTator Score 102.07

Knowledge Summary


No data available


  Differential Expression (10)

Disease log2 FC p
astrocytic glioma 2.300 1.1e-02
posterior fossa group B ependymoma 3.500 2.5e-12
oligodendroglioma 3.100 9.6e-04
osteosarcoma -2.232 1.1e-05
cystic fibrosis 1.771 1.1e-04
atypical teratoid/rhabdoid tumor -1.300 6.7e-06
pancreatic ductal adenocarcinoma liver m... -1.470 6.2e-03
group 4 medulloblastoma 1.600 1.1e-04
pilocytic astrocytoma 3.000 1.2e-06
lung carcinoma 2.500 6.9e-13

Pathway (1)

Protein-protein Interaction (5)

Gene RIF (11)

24667918 Microarray analysis indicates HIV-1 Tat-induced upregulation of SPARC related modular calcium binding 1 (SMOC1) in primary human brain microvascular endothelial cells
23333304 Microarray analysis indicates HIV-1 Tat-induced upregulation of SPARC related modular calcium binding 1 (SMOC1) in primary human brain microvascular endothelial cells
23274784 IL-17A but not IL-22 suppresses the replication of hepatitis B virus by inducing the expression of MxA and OAS.
23263445 SMOC1 provides a link between prenatal hormone exposure and digit ratio.
21750680 Homozygosity mapping and subsequent targeted mutation analysis of a locus on 14q24.2 identified homozygous mutations in SMOC1 (SPARC-related modular calcium binding 1) in eight unrelated families with Waardenburg Anophthalmia syndrome.
21349332 The present study thus identified SPARC related modular calcium binding 1 as a new cancer-associated protein capable of interacting with tenascin-C in vitro
21194680 Waardenburg anophthalmia syndrome is genetically heterogeneous; a second was locus found on chromosome 14, and mutations in SMOC1 were shown also cause this syndrome.
21194678 these findings indicate that SMOC1/Smoc1 is essential for ocular and limb development in both humans and mice.
20359165 Analyzed the secretory protein profiles of BMSCs grown in osteogenic medium (OSM) and identified SPARC-related modular calcium-binding protein 1 (SMOC1), a member of the SPARC family, as a regulator of osteoblast differentiation of BMSCs.
17386346 SMOC-1 is of physiological interest because it codes a secreted glycoprotein with five domains, each containing regions homologous to those on other proteins that mediate cell-matrix interactions.
12130637 isolation of the novel gene SMOC-1 encoding a secreted modular protein containing an EF-hand calcium-binding domain; localization within basement membranes in kidney and skeletal muscle and expression in the zona pellucida surrounding the oocyte

AA Sequence

LKGCLGVSKEGRLV                                                            421 - 434

Text Mined References (20)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
24249740 2014 Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.
24057671 2014 Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
23646827 2013 Mutations in ALDH1A3 cause microphthalmia.
23274784 2013 IL-17A but not IL-22 suppresses the replication of hepatitis B virus mediated by over-expression of MxA and OAS mRNA in the HepG2.2.15 cell line.
23263445 2013 Genetic association suggests that SMOC1 mediates between prenatal sex hormones and digit ratio.
23222517 2012 Seventy-five genetic loci influencing the human red blood cell.
23088713 2012 Protein interactions of the transcription factor Hoxa1.
21750680 2011 Loss of the BMP antagonist, SMOC-1, causes Ophthalmo-acromelic (Waardenburg Anophthalmia) syndrome in humans and mice.
21349332 2011 SMOC1 is a tenascin-C interacting protein over-expressed in brain tumors.
21194680 2011 Mutations in the SPARC-related modular calcium-binding protein 1 gene, SMOC1, cause waardenburg anophthalmia syndrome.
21194678 2011 SMOC1 is essential for ocular and limb development in humans and mice.
20359165 2010 Secretome analysis of human BMSCs and identification of SMOC1 as an important ECM protein in osteoblast differentiation.
17386346 2007 A whole genome scan for pulse pressure/stroke volume ratio in African Americans: the HyperGEN study.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12508121 2003 The DNA sequence and analysis of human chromosome 14.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12130637 2002 Characterization of SMOC-1, a novel modular calcium-binding protein in basement membranes.