SMCP
Sperm mitochondrial-associated cysteine-rich protein
Protein Summary
Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity). Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. [provided by RefSeq, Jul 2008]
- ENST00000368765
- ENSP00000357754
- ENSG00000163206
- MCS
- MCSP
- MCS
- MCSP
- HSMCSGEN1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell line | 0.48 | ||
kinase perturbation | 0.48 | ||
disease perturbation | 0.43 | ||
disease | 0.42 | ||
cellular component | 0.34 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.18 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 188 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.18 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 188 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0