Property Summary

NCBI Gene PubMed Count 23
PubMed Score 79.44
PubTator Score 27.22

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (14)

Disease log2 FC p
Rheumatoid Arthritis 2.500 1.2e-03
astrocytic glioma 1.200 8.8e-03
ependymoma 1.600 1.9e-02
psoriasis -1.900 6.8e-05
glioblastoma 1.700 3.1e-05
osteosarcoma 2.000 2.1e-05
atypical teratoid / rhabdoid tumor 2.100 7.3e-05
medulloblastoma, large-cell 1.500 1.9e-04
primitive neuroectodermal tumor 1.300 2.4e-03
intraductal papillary-mucinous carcinoma... 1.100 1.4e-02
adult high grade glioma 1.300 4.4e-03
pilocytic astrocytoma 1.100 9.4e-04
Pick disease 1.200 1.0e-03
ovarian cancer 1.500 1.3e-04

 GO Function (1)

Protein-protein Interaction (1)

Gene RIF (12)

PMID Text
26983541 results uncover a novel role for the Smc5/6 complex as a restriction factor selectively blocking extrachromosomal DNA transcription; by destroying this complex, HBx relieves the inhibition to allow productive hepatitis B virus gene expression
25145851 Structural maintenance of chromosomes (SMC) complexes, which in eukaryotic cells include cohesin, condensin and the Smc5/6 complex, are central regulators of chromosome dynamics
24258023 Depletion of Smc5 and Smc6 resulted in aberrant mitotic chromosome phenotypes that were accompanied by the abnormal distribution of topoisomerase IIalpha (topo IIalpha) and condensins and by chromosome segregation errors
21550342 Studies indicate that Nse1 may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5/6 complex.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19861517 Observational study of gene-disease association. (HuGE Navigator)
19502785 SMC5 is crucial for mitotic progression and maintenance of sister chromatid cohesion during mitosis.
18667531 Nse1 RING-like motif is a protein-protein interaction domain required for Smc5-Smc6 holocomplex integrity and recruitment to, or retention at, DNA lesions
18086888 The four non-SMC components of the human complex were identified and characterized and it was demonstrated that the MAGEG1 protein is part of this complex.
17589526 SMC5/6 complex facilitates telomere homologous recombination and elongation in alternative lengthening of telomeres cells through SUMOylation of telomere-binding proteins.
16810316 SMC5/6 complex is recruited to nuclease-induced double-strand breaks (DSBs) and is required for the recruitment of cohesin to DSBs.
16055714 the human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells

AA Sequence

MATPSKKTSTPSPQPSKRALPRDPSSEVPSKRKNSAPQLPLLQSSGPFVEGSIVRISMENFLTYDICEVS      1 - 70
PGPHLNMIVGANGTGKSSIVCAICLGLAGKPAFMGRADKVGFFVKRGCSRGMVEIELFRASGNLVITREI     71 - 140
DVAKNQSFWFINKKSTTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHK    141 - 210
YHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQ    211 - 280
EYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDK    281 - 350
HIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGE    351 - 420
IIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTIN    421 - 490
MKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQY    491 - 560
GFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKV    561 - 630
ISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLER    631 - 700
KTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDL    701 - 770
ILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQ    771 - 840
TQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGK    841 - 910
KVELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGIRIRVKFRSS    911 - 980
TQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINERRVFEMVVNTACKENTSQYF    981 - 1050
FITPKLLQNLPYSEKMTVLFVYNGPHMLEPNTWNLKAFQRRRRRITFTQPS                      1051 - 1101
//

Text Mined References (28)

PMID Year Title
26983541 2016 Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
25931565 2015 DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links.
25145851 2014 The maintenance of chromosome structure: positioning and functioning of SMC complexes.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24258023 2014 Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21550342 2011 The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability.
21269460 2011 Initial characterization of the human central proteome.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19861517 2009 Predisposition for TMPRSS2-ERG fusion in prostate cancer by variants in DNA repair genes.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19502785 2009 SMC5 and MMS21 are required for chromosome cohesion and mitotic progression.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
18667531 2008 Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability.
18086888 2008 Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex.
17589526 2007 The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins.
16810316 2006 Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16055714 2005 Human MMS21/NSE2 is a SUMO ligase required for DNA repair.
15601840 2005 Composition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complex.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15164053 2004 DNA sequence and analysis of human chromosome 9.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12168954 2002 Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
11408570 2001 Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex.
9628581 1998 Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.