SMAD9
Mothers against decapentaplegic homolog 9
Protein Summary
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
- ENST00000350148
- ENSP00000239885
- ENSG00000120693
- ENST00000379826
- ENSP00000369154
- ENST00000399275
- ENSP00000382216
- MADH6
- MADH9
- SMAD8
- PPH2
- MADH6
- MADH9
- SMAD8
- SMAD8A
- SMAD8B
- SMAD8/9
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
biological process | 0.8 | ||
virus perturbation | 0.79 | ||
tissue sample | 0.68 | ||
cellular component | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 766.77 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 307 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 766.77 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 307 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0