Tbio SMAD7 Mothers against decapentaplegic homolog 7

Protein Summary

Description

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• O15105
• B7Z773
• K7EQ10
• O14740
• Q6DK23
• MAD homolog 7

Gene Name

• SMAD7

Ensembl ID

• ENST00000262158
• ENSP00000262158
• ENSG00000101665
• ENST00000589634
• ENSP00000467621
• ENST00000591805
• ENSP00000466902

Symbol

• MADH7
• MADH8
• CRCS3
• MADH7
• MADH8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.96
hub protein	0.95
PubMedID	0.95
gene perturbation	0.94

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Mothers Against Decapentaplegic Homolog 7

DTO Classes

Protein / Transcription Factor / Mothers Against Decapentaplegic Homolog 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1019.17   (req: < 5)

Gene RIFs: 299   (req: <= 3)

Antibodies: 485   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1019.17   (req: >= 5)

Gene RIFs: 299   (req: > 3)

Antibodies: 485   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0