Tbio SLITRK6 SLIT and NTRK-like protein 6

Protein Summary

Description

Regulator of neurite outgrowth required for normal hearing and vision. This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. This protein functions as a regulator of neurite outgrowth required for normal hearing and vision. Mutations in this gene are a cause of myopia and deafness. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• Q9H5Y7
• A8K9S8
• Q495Q0
• Q6AW93
• Q9HAA8
• Q9NT60

Gene Name

• SLITRK6

Ensembl ID

• ENST00000400286
• ENSP00000383143
• ENSG00000184564

Symbol

• DFNMYP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.64
gene perturbation	0.59
microRNA	0.59
tissue sample	0.59
cell type or tissue	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.63   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 244   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.63   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0