Tdark SLITRK4 SLIT and NTRK-like protein 4

Protein Summary

Description

It is involved in synaptogenesis and promotes synapse differentiation (PubMed:27812321). Suppresses neurite outgrowth (By similarity). This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q8IW52
• Q5JXG3
• Q8TCM8
• Q96DL3

Gene Name

• SLITRK4

Ensembl ID

• ENST00000338017
• ENSP00000336627
• ENSG00000179542
• ENST00000356928
• ENSP00000349400
• ENST00000596188
• ENSP00000469205

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.71
tissue sample	0.65
cell type or tissue	0.6
protein domain	0.58
PubMedID	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.69   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 226   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.69   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0