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Tdark Schlafen family member 5

May have a role in hematopoietic cell differentiation.

 Comments

Property Summary

NCBI Gene PubMed Count 7
PubMed Score 0.00
PubTator Score 2.84

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0

Expression

  Differential Expression (20)

Disease log2 FC p
hepatocellular carcinoma 1.100 3.1e-04
ependymoma 1.400 1.3e-02
oligodendroglioma 1.100 5.1e-03
osteosarcoma 1.913 3.6e-04
cystic fibrosis 2.021 4.3e-06
atypical teratoid / rhabdoid tumor 1.100 1.7e-04
glioblastoma 1.300 6.3e-03
juvenile dermatomyositis 1.851 2.8e-11
acute quadriplegic myopathy 1.515 6.0e-08
pancreatic ductal adenocarcinoma liver m... 2.244 2.2e-03
tuberculosis and treatment for 6 months -1.900 6.1e-06
sarcoidosis 1.100 1.3e-02
pediatric high grade glioma 1.100 2.0e-03
primary Sjogren syndrome 1.300 9.5e-04
subependymal giant cell astrocytoma 1.099 4.5e-02
psoriasis 1.100 2.9e-04
lung carcinoma -2.500 3.4e-24
Pick disease 1.300 2.9e-06
ulcerative colitis 2.500 5.6e-09
ovarian cancer 1.200 1.1e-02

Synonym

Accession Q08AF3 Q08AF2 Q8WU54 Q96A82
Symbols

Gene

SLFN5

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (7)

 GO Function (1)

 GO Component (1)

 GO Process (1)

 Compartment GO Term (3)

 HCA RNA Cell Line (56)

See all...

Pathway (1)

Gene RIF (2)

PMID Text
26012550 SLFN5 exhibits key roles in controlling motility and invasiveness of renal cell carcinoma cells by negatively controlling expression of MMP-1, MMP-13, and several other genes involved in the control of malignant cell motility.
20956525 SLFN5 knockdown also resulted in increased invasion in three-dimensional collagen, suggesting a dual role for SLFN5 in the regulation of invasion and anchorage-independent growth of melanoma cells.

AA Sequence 

MSLRIDVDTNFPECVVDAGKVTLGTQQRQEMDPRLREKQNEIILRAVCALLNSGGGIIKAEIENKGYNYE      1 - 70
RHGVGLDVPPIFRSHLDKMQKENHFLIFVKSWNTEAGVPLATLCSNLYHRERTSTDVMDSQEALAFLKCR     71 - 140
TQTPTNINVSNSLGPQAAQGSVQYEGNINVSAAALFDRKRLQYLEKLNLPESTHVEFVMFSTDVSHCVKD    141 - 210
RLPKCVSAFANTEGGYVFFGVHDETCQVIGCEKEKIDLTSLRASIDGCIKKLPVHHFCTQRPEIKYVLNF    211 - 280
LEVHDKGALRGYVCAIKVEKFCCAVFAKVPSSWQVKDNRVRQLPTREWTAWMMEADPDLSRCPEMVLQLS    281 - 350
LSSATPRSKPVCIHKNSECLKEQQKRYFPVFSDRVVYTPESLYKELFSQHKGLRDLINTEMRPFSQGILI    351 - 420
FSQSWAVDLGLQEKQGVICDALLISQNNTPILYTIFSKWDAGCKGYSMIVAYSLKQKLVNKGGYTGRLCI    421 - 490
TPLVCVLNSDRKAQSVYSSYLQIYPESYNFMTPQHMEALLQSLVIVLLGFKSFLSEELGSEVLNLLTNKQ    491 - 560
YELLSKNLRKTRELFVHGLPGSGKTILALRIMEKIRNVFHCEPANILYICENQPLKKLVSFSKKNICQPV    561 - 630
TRKTFMKNNFEHIQHIIIDDAQNFRTEDGDWYGKAKFITQTARDGPGVLWIFLDYFQTYHLSCSGLPPPS    631 - 700
DQYPREEINRVVRNAGPIANYLQQVMQEARQNPPPNLPPGSLVMLYEPKWAQGVPGNLEIIEDLNLEEIL    701 - 770
IYVANKCRFLLRNGYSPKDIAVLFTKASEVEKYKDRLLTAMRKRKLSQLHEESDLLLQIGDASDVLTDHI    771 - 840
VLDSVCRFSGLERNIVFGINPGVAPPAGAYNLLLCLASRAKRHLYILKASV                       841 - 891
//

Text Mined References (8)

PMID Year Title
26012550 2015 Human Schlafen 5 (SLFN5) Is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma Cells.
21269460 2011 Initial characterization of the human central proteome.
20956525 2010 Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
9846487 1998 Schlafen, a new family of growth regulatory genes that affect thymocyte development.