| Tchem | Sodium/hydrogen exchanger 5 |
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 4369 | 4.1e-10 |
| glioblastoma | 5572 | 5.2e-06 |
| primitive neuroectodermal tumor | 3031 | 7.5e-05 |
| medulloblastoma, large-cell | 6234 | 1.5e-04 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Secretory diarrhea | 6 | 3.184 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | -1.400 | 4.1e-10 |
| glioblastoma | -1.200 | 5.2e-06 |
| medulloblastoma, large-cell | -1.300 | 1.5e-04 |
| primitive neuroectodermal tumor | -1.200 | 7.5e-05 |
| PMID | Text | |
|---|---|---|
| 24936055 | These data reveal a unique role for AMPK and NHE5 in regulating the pH homeostasis of hippocampal neurons during metabolic stress. | |
| 24874739 | EIPA, a potent and specific inhibitor of Na+/H+ exchanger activity, significantly inhibits the Nef internalization into M2-macrophages, indicating that Nef is imported by Na+/H+ exchanger (solute carrier family 9, subfamily A) | |
| 21551074 | overexpression of NHE5 inhibits spine growth in response to neuronal activity | |
| 21296876 | discrete elements of an elaborate sorting signal in NHE5 contribute to beta-arrestin2 binding and trafficking along the recycling endosomal pathway. | |
| 19276089 | SCAMP2 regulates NHE5 transit through recycling endosomes and promotes its surface targeting in an Arf6-dependent manner. | |
| 16920332 | RACK1 activates NHE5 both by integrin-dependent and independent pathways, which may coordinate cellular ion homeostasis during cell-matrix adhesion. | |
| 15699339 | beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform. | |
| 12205089 | observations demonstrate that NHE5 is localized to the recycling endosomal pathway and is dynamically regulated by phosphatidylinositol 3'-kinase and by the state of F-actin assembly |
MLRAALSLLALPLAGAAEEPTQKPESPGEPPPGLELFRWQWHEVEAPYLVALWILVASLAKIVFHLSRKV 1 - 70 TSLVPESCLLILLGLVLGGIVLAVAKKAEYQLEPGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAV 71 - 140 VGTLWNAFTTGAALWGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFGES 141 - 210 LLNDAVTVVLYKVCNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVRIIEP 211 - 280 LLVFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGIS 281 - 350 AVDSSKWAWDSGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLD 351 - 420 RTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVKRSEHHKPTLNQELHEHTFDHILAAVEDVVGH 421 - 490 HGYHYWRDRWEQFDKKYLSQLLMRRSAYRIRDQIWDVYYRLNIRDAISFVDQGGHVLSSTGLTLPSMPSR 491 - 560 NSVAETSVTNLLRESGSGACLDLQVIDTVRSGRDREDAVMHHLLCGGLYKPRRRYKASCSRHFISEDAQE 561 - 630 RQDKEVFQQNMKRRLESFKSTKHNICFTKSKPRPRKTGRRKKDGVANAEATNGKHRGLGFQDTAAVILTV 631 - 700 ESEEEEEESDSSETEKEDDEGIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKELPWKSGQGD 701 - 770 LAVYVSSETTKIVPVDMQTGWNQSISSLESLASPPCNQAPILTCLPPHPRGTEEPQVPLHLPSDPRSSFA 771 - 840 FPPSLAKAGRSRSESSADLPQQQELQPLMGHKDHTHLSPGTATSHWCIQFNRGSRL 841 - 896 //
| PMID | Year | Title | |
|---|---|---|---|
| 24936055 | 2014 | Activation of AMP-activated protein kinase regulates hippocampal neuronal pH by recruiting Na(+)/H(+) exchanger NHE5 to the cell surface. | |
| 21551074 | 2011 | Regulation of dendritic spine growth through activity-dependent recruitment of the brain-enriched Na?/H? exchanger NHE5. | |
| 21296876 | 2011 | CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis. | |
| 19276089 | 2009 | Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5. | |
| 16920332 | 2007 | RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity. | |
| 15699339 | 2005 | beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12598940 | 2003 | [Tissue-specific expression of Na+ -H+ exchanger isoforms at two developmental stages of human fetus]. | |
| 12576672 | 2003 | Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 12417987 | 2002 | A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. | |
| 12205089 | 2002 | Clathrin-mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform. Regulation by phosphatidylinositol 3'-kinase and the actin cytoskeleton. | |
| 9933642 | 1999 | Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain. | |
| 9933641 | 1999 | Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain. | |
| 7759094 | 1995 | Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1. |
