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Tchem Sodium/hydrogen exchanger 5

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).

 Comments

Property Summary

Ligand Count 1
NCBI Gene PubMed Count 15
PubMed Score 17.09
PubTator Score 16.33

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8
Disease Target Count Z-score Confidence
Secretory diarrhea 10 3.255 1.6
Metabolic acidosis 90 3.023 1.5

Expression

  Differential Expression (4)

Disease log2 FC p
atypical teratoid / rhabdoid tumor -1.400 4.1e-10
glioblastoma -1.200 5.2e-06
medulloblastoma, large-cell -1.300 1.5e-04
primitive neuroectodermal tumor -1.200 7.5e-05

Synonym

Accession Q14940 A5PKY7 Q9Y626
Symbols NHE5

Gene

SLC9A5

  Ortholog (8)

Species Source Disease
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA

 UniProt Keyword (12)

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 GO Function (2)

 GO Component (2)

 GO Process (5)

 Compartment GO Term (12)

 HCA RNA Cell Line (55)

See all...

Pathway (4)

Protein-protein Interaction (5)

RAP1GDS1   DIRAS1   PRKAB1   PRKAB2   PRKAA1  

Drug (1)

Structure of amiloride

amiloride
pKi 4.68

Gene RIF (8)

AA Sequence 

MLRAALSLLALPLAGAAEEPTQKPESPGEPPPGLELFRWQWHEVEAPYLVALWILVASLAKIVFHLSRKV      1 - 70
TSLVPESCLLILLGLVLGGIVLAVAKKAEYQLEPGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAV     71 - 140
VGTLWNAFTTGAALWGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFGES    141 - 210
LLNDAVTVVLYKVCNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVRIIEP    211 - 280
LLVFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGIS    281 - 350
AVDSSKWAWDSGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLD    351 - 420
RTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVKRSEHHKPTLNQELHEHTFDHILAAVEDVVGH    421 - 490
HGYHYWRDRWEQFDKKYLSQLLMRRSAYRIRDQIWDVYYRLNIRDAISFVDQGGHVLSSTGLTLPSMPSR    491 - 560
NSVAETSVTNLLRESGSGACLDLQVIDTVRSGRDREDAVMHHLLCGGLYKPRRRYKASCSRHFISEDAQE    561 - 630
RQDKEVFQQNMKRRLESFKSTKHNICFTKSKPRPRKTGRRKKDGVANAEATNGKHRGLGFQDTAAVILTV    631 - 700
ESEEEEEESDSSETEKEDDEGIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKELPWKSGQGD    701 - 770
LAVYVSSETTKIVPVDMQTGWNQSISSLESLASPPCNQAPILTCLPPHPRGTEEPQVPLHLPSDPRSSFA    771 - 840
FPPSLAKAGRSRSESSADLPQQQELQPLMGHKDHTHLSPGTATSHWCIQFNRGSRL                  841 - 896
//

Text Mined References (16)

PMID Year Title