Property Summary

NCBI Gene PubMed Count 29
PubMed Score 77.76
PubTator Score 45.88

Knowledge Summary


No data available


  Differential Expression (7)

Disease log2 FC p
intraductal papillary-mucinous adenoma (... 3.500 5.2e-05
intraductal papillary-mucinous carcinoma... 2.700 7.3e-03
intraductal papillary-mucinous neoplasm ... 1.900 3.2e-02
colon cancer -2.900 1.2e-02
lung cancer 4.000 1.6e-06
ulcerative colitis -1.200 6.7e-04
psoriasis -2.100 3.0e-67

Gene RIF (12)

24874739 EIPA, a potent and specific inhibitor of Na+/H+ exchanger activity, significantly inhibits the Nef internalization into M2-macrophages, indicating that Nef is imported by Na+/H+ exchanger (solute carrier family 9, subfamily A)
24376510 These data indicate that the acid-dependent NHE2 stimulation is implemented by transcriptional upregulation of NHE2 via acid-induced Egr-1 in the intestinal epithelial cells.
22052014 Phosphorylation of nPKC-delta results in activation of ERK1/2 kinase and subsequent induction of Egr-1. Subsequently, Egr-1 directly targets NHE2 promoter and promotes NHE2 transcriptional upregulation by interaction with NHE2-PMA response element.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19479940 The functional and molecular expression of NHEs in cultured human endolymphatic sac (ES) epithelial cells was determined and the effect of IFN-gamma on NHE function, was examined.
19389806 Report morphological adaptation with preserved proliferation/NHE2 content in the colon of patients with short bowel syndrome.
19056765 Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3 in intestinal epithelial cells.
17943310 T84 human colon cells contain three isoforms of the Na+/H+ exchanger, NHE1, NHE2, and NHE4, but not the Cl-dependent NHE
17881426 No mutation was found in the coding regions and intron-exon boundaries of the genes for CA II, CA IV, CA XIV, kNCB1, NHE3, NHE8, NHRF1, NHRF2 and SLC26A6 amplified from genomic DNA of family members with pRTA.
17561809 expression of the human NHE2 promoter is controlled by Sp1 and Sp3 by interactions with the proximal promoter and the transcription initiation site of NHE2
16982955 Observational study of gene-disease association. (HuGE Navigator)
15664417 In humans, NHE2 transcripts appear to be gestationally regulated, which may contribute to changes in NHE activity.

AA Sequence


Text Mined References (31)

PMID Year Title
25486439 2015 Gene expression in the human endolymphatic sac: the solute carrier molecules in endolymphatic fluid homeostasis.
25423035 2014 Predictive gene signatures: molecular markers distinguishing colon adenomatous polyp and carcinoma.
25406947 2014 Meta-analysis of human methylation data for evidence of sex-specific autosomal patterns.
24376510 2013 Extracellular acidosis stimulates NHE2 expression through activation of transcription factor Egr-1 in the intestinal epithelial cells.
22052014 2012 PKC?-dependent activation of ERK1/2 leads to upregulation of the human NHE2 transcriptional activity in intestinal epithelial cell line C2BBe1.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19479940 2009 Interferon-gamma suppresses Na+ -H+ exchanger in cultured human endolymphatic sac epithelial cells.
19389806 2009 Morphological adaptation with preserved proliferation/transporter content in the colon of patients with short bowel syndrome.
19056765 2009 Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3.
17943310 2008 NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells.
17881426 2008 Familial pure proximal renal tubular acidosis--a clinical and genetic study.
17561809 2007 Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site.
16982955 2006 Extensive genetic analysis of 10 candidate genes for hypertension in Japanese.
16959974 2006 The consensus coding sequences of human breast and colorectal cancers.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15664417 2005 Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCR.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11408268 2001 Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement.
11350981 2001 Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers.
11254504 2001 The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterization.
10579058 1999 Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3.
10444453 1999 Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2.
10187839 1999 Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia.
9847074 1998 Toward a complete human genome sequence.
8901634 1996 A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange.
8843774 1996 Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA.
8595899 1995 Molecular cloning, sequencing, chromosomal localization, and tissue distribution of the human Na+/H+ exchanger (SLC9A2).
7683411 1993 Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2).
2346229 1990 Quantitative analysis of the retrograde reaction of motoneurons with an image analyser.
1318024 1992 Human placental syncytiotrophoblast expresses two pharmacologically distinguishable types of Na(+)-H+ exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (basal) membrane.