| Tchem | Sodium- and chloride-dependent glycine transporter 1 |
The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. [provided by RefSeq, Jun 2016]
Comments
| Disease | Target Count |
|---|---|
| Amphetamine-Related Disorders | 74 |
| Disease | Target Count | P-value |
|---|---|---|
| cutaneous lupus erythematosus | 1056 | 2.8e-03 |
| oligodendroglioma | 2849 | 3.6e-03 |
| psoriasis | 6685 | 3.9e-03 |
| ependymoma | 2514 | 4.2e-03 |
| pediatric high grade glioma | 2712 | 5.1e-03 |
| glioblastoma | 5572 | 5.5e-03 |
| astrocytic glioma | 2241 | 1.0e-02 |
| Polycystic Ovary Syndrome | 334 | 1.2e-02 |
| mucosa-associated lymphoid tissue lymphoma | 480 | 3.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Glycine encephalopathy | 28 | 4.59 | 2.3 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | 1.300 | 1.0e-02 |
| ependymoma | 1.500 | 4.2e-03 |
| oligodendroglioma | 1.300 | 3.6e-03 |
| cutaneous lupus erythematosus | -1.200 | 2.8e-03 |
| psoriasis | -1.200 | 3.9e-03 |
| glioblastoma | 1.700 | 5.5e-03 |
| pediatric high grade glioma | 1.300 | 5.1e-03 |
| Polycystic Ovary Syndrome | -1.035 | 1.2e-02 |
| mucosa-associated lymphoid tissue lympho... | 1.150 | 3.8e-02 |
CHEMBL398398
pIC50 6.00
CHEMBL428386
pIC50 6.00
CHEMBL240031
pIC50 6.00
CHEMBL239999
pIC50 6.00
CHEMBL1834686
pIC50 6.00
CHEMBL3114963
pIC50 6.00
CHEMBL1834682
pIC50 6.00
CHEMBL64154
pIC50 6.00
CHEMBL377350
pEC50 6.01
CHEMBL377109
pEC50 6.01
CHEMBL62571
pIC50 6.01
CHEMBL399144
pIC50 6.02
CHEMBL250152
pIC50 6.02
CHEMBL209380
pEC50 6.02
CHEMBL213672
pEC50 6.02
CHEMBL213982
pIC50 6.02
CHEMBL1171648
pEC50 6.05
CHEMBL3114964
pIC50 6.05
CHEMBL3115207
pIC50 6.05
CHEMBL519701
pIC50 6.06
| PMID | Text | |
|---|---|---|
| 26302655 | Study found that temporal lobe epilepsy is associated with increased levels of GlyT1 | |
| 23132267 | Following biopterin administration, glycine transporter type I occupancy correlates with biopterin plasma concentration. | |
| 22705056 | The increased sensitivity of human GlyT1c to sanguinarine is abolished by the mutation of only cysteine 475. | |
| 22425803 | Synaptic and extrasynaptic concentrations of glycine are regulated by its type-1 glycine transporter, which is primarily expressed in astroglial and glutamatergic cell membranes. | |
| 21688322 | Human positron-emission tomography studies determine the test-retest reproducibility of [11C]GSK931145, a ligand which readily enters the brain, displaying a heterogeneous uptake which corresponds well with the known distribution of GlyT-1. | |
| 21628872 | metabolic functions of GLYT1 in intestine: metabolism/regulation of glycine/glutathione; role in response to physiological stress (e.g., oxidative stress); possible role in pathophysiology/therapy of inflammatory bowel diseases [REVIEW] | |
| 19650813 | Observational study of gene-disease association. (HuGE Navigator) | |
| 19556729 | association between SLC6A9 SNPs and essential hypertension in a Japanese population, suggesting that SLC6A9 is a susceptibility locus for essential hypertension. | |
| 19556729 | Observational study of gene-disease association. (HuGE Navigator) | |
| 19427831 | the results suggest that GLYT1 and membrane rafts are co-localized in the membrane, and that this influences the rate of glycine transport. | |
| 19086053 | Observational study of gene-disease association. (HuGE Navigator) | |
| 18638388 | SLC6A9 gene is associated with schizophrenia. | |
| 18638388 | Observational study of gene-disease association. (HuGE Navigator) | |
| 18411704 | Single nucleotide polymorphism or haplotype of the gene produce risks for susceptibility to drug dependence. | |
| 17582620 | Genetic variation of the glycine transporter 1 gene may contribute to individual vulnerability to methamphetamine dependence and psychosis. | |
| 17582620 | Observational study of gene-disease association. (HuGE Navigator) | |
| 16841561 | Observational study of gene-disease association. (HuGE Navigator) | |
| 16604304 | Observational study of gene-disease association. (HuGE Navigator) | |
| 16121932 | The mechanism of allosteric interaction of cytoplasmic and extracellular Cl- in the glial glycine transporter (hGlyTlb). |
MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKVWHGAYNSGLL 1 - 70 PQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMF 71 - 140 PYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSS 141 - 210 MTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDI 211 - 280 GNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTP 281 - 350 QWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF 351 - 420 MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGN 421 - 490 EWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDI 491 - 560 QMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMF 561 - 630 RLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSR 631 - 700 LQDSRI 701 - 706 //
| PMID | Year | Title | |
|---|---|---|---|
| 26302655 | 2015 | Glycine transporter 1 is a target for the treatment of epilepsy. | |
| 24962325 | 2014 | Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. | |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. | |
| 23132267 | 2013 | Glycine transporter type 1 occupancy by bitopertin: a positron emission tomography study in healthy volunteers. | |
| 22705056 | 2012 | Molecular basis for differential glycine transporters sensitivity to sanguinarine. | |
| 22425803 | 2012 | Interactions between glycine transporter type 1 (GlyT-1) and some inhibitor molecules - glycine transporter type 1 and its inhibitors (review). | |
| 21688322 | 2011 | Translational characterization of [11C]GSK931145, a PET ligand for the glycine transporter type 1. | |
| 21628872 | 2011 | The glycine transporter GLYT1 in human intestine: expression and function. | |
| 19650813 | 2009 | No association of alcohol dependence with SLC6A5 and SLC6A9 glycine transporter polymorphisms. | |
| 19556729 | 2009 | Association of SLC6A9 gene variants with human essential hypertension. | |
| 19427831 | 2009 | Glycine transporter 1 associates with cholesterol-rich membrane raft microdomains. | |
| 19086053 | 2009 | Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. | |
| 18638388 | 2008 | Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia. | |
| 18411704 | 2008 | [Potential genetic predictors for individual vulnerability to substance dependence]. | |
| 17582620 | 2008 | The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder. | |
| 16841561 | 2006 | Polymorphisms in glycine transporter with schizophrenia. | |
| 16710414 | 2006 | The DNA sequence and biological annotation of human chromosome 1. | |
| 16604304 | 2006 | Association study of polymorphisms in glycine transporter with schizophrenia. | |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | |
| 16121932 | The mechanism of allosteric interaction of cytoplasmic and extracellular Cl- in the glial glycine transporter (hGlyTlb). | ||
| 15146197 | 2004 | Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. | |
| 12091465 | 2002 | Glycine transporter isoforms show differential subcellular localization in PC12 cells. | |
| 11360303 | 2001 | Glyt-1 expression in cultured human Müller cells and intact retinae. | |
| 11159884 | 2001 | Glycine supply to human enterocytes mediated by high-affinity basolateral GLYT1. | |
| 10722844 | 2000 | Characterization of the interactions between the glycine transporters GLYT1 and GLYT2 and the SNARE protein syntaxin 1A. | |
| 10625616 | 2000 | GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1. | |
| 10606742 | 1999 | Cloning, functional characterisation and population analysis of a variant form of the human glycine type 2 transporter. | |
| 8494645 | 1993 | Two glycine transporter variants with distinct localization in the CNS and peripheral tissues are encoded by a common gene. | |
| 8183239 | 1994 | Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes. | |
| 7721869 | 1995 | The role of N-glycosylation in the targeting and activity of the GLYT1 glycine transporter. | |
| 7587377 | 1995 | Assignment of SLC6A9 to human chromosome band 1p33 by in situ hybridization. |
