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Tchem Sodium- and chloride-dependent glycine transporter 1

Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.

The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. [provided by RefSeq, Jun 2016]

 Comments

Property Summary

Ligand Count 500
NCBI Gene PubMed Count 32
PubMed Score 10.45
PubTator Score 153.87

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8
Disease Target Count Z-score Confidence
Glycine encephalopathy 29 4.539 2.3
Hyperekplexia 16 3.323 1.7

Expression

  Differential Expression (9)

Disease log2 FC p
astrocytic glioma 1.300 1.0e-02
cutaneous lupus erythematosus -1.200 2.8e-03
ependymoma 1.500 4.2e-03
glioblastoma 1.700 5.5e-03
mucosa-associated lymphoid tissue lympho... 1.150 3.8e-02
oligodendroglioma 1.300 3.6e-03
pediatric high grade glioma 1.300 5.1e-03
Polycystic ovary syndrome -1.035 1.2e-02
psoriasis -1.200 3.9e-03

Synonym

Accession P48067 A6NDH1 A6NII2 A6NNZ8 Q5TAB8 Q5TAB9 Q5TAC0 GlyT-1
Symbols GLYT1
GCENSG

Gene

SLC6A9

PANTHER Protein Class (2)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (12)

See all...

 GO Function (3)

 GO Component (4)

 GO Process (2)

 Compartment GO Term (14)

 OMIM Phenotype (1)

 MGI Phenotype (9)

 GWAS Trait (2)

 HCA RNA Cell Line (56)

See all...

Pathway (6)

Ligand (500)

Structure of CHEMBL398398

CHEMBL398398
pIC50 6.00

Structure of CHEMBL428386

CHEMBL428386
pIC50 6.00

Structure of CHEMBL240031

CHEMBL240031
pIC50 6.00

Structure of CHEMBL239999

CHEMBL239999
pIC50 6.00

Structure of CHEMBL1834686

CHEMBL1834686
pIC50 6.00

Structure of CHEMBL3114963

CHEMBL3114963
pIC50 6.00

Structure of CHEMBL1834682

CHEMBL1834682
pIC50 6.00

Structure of CHEMBL64154

CHEMBL64154
pIC50 6.00

Structure of CHEMBL377350

CHEMBL377350
pEC50 6.01

Structure of CHEMBL377109

CHEMBL377109
pEC50 6.01

Structure of CHEMBL62571

CHEMBL62571
pIC50 6.01

Structure of CHEMBL399144

CHEMBL399144
pIC50 6.02

Structure of CHEMBL250152

CHEMBL250152
pIC50 6.02

Structure of CHEMBL209380

CHEMBL209380
pEC50 6.02

Structure of CHEMBL213672

CHEMBL213672
pEC50 6.02

Structure of CHEMBL213982

CHEMBL213982
pIC50 6.02

Structure of CHEMBL1171648

CHEMBL1171648
pEC50 6.05

Structure of CHEMBL3114964

CHEMBL3114964
pIC50 6.05

Structure of CHEMBL3115207

CHEMBL3115207
pIC50 6.05

Structure of CHEMBL519701

CHEMBL519701
pIC50 6.06

Gene RIF (21)

AA Sequence 

MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKVWHGAYNSGLL      1 - 70
PQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMF     71 - 140
PYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSS    141 - 210
MTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDI    211 - 280
GNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTP    281 - 350
QWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF    351 - 420
MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGN    421 - 490
EWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDI    491 - 560
QMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMF    561 - 630
RLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSR    631 - 700
LQDSRI                                                                    701 - 706
//

Text Mined References (33)

PMID Year Title