| Tchem | Sodium- and chloride-dependent glycine transporter 1 |
The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. [provided by RefSeq, Jun 2016]
Comments
Property Summary
| Ligand Count | 512 |
| NCBI Gene PubMed Count | 32 |
| PubMed Score | 10.45 |
| PubTator Score | 153.87 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Amphetamine-Related Disorders | 74 | 0.0 | 0.0 |
| GLYCINE ENCEPHALOPATHY WITH NORMAL SERUM GLYCINE | 1 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Alcoholic Intoxication, Chronic | 289 |
| Nonorganic psychosis | 84 |
| Psychotic Disorders | 151 |
| Schizophrenia | 1160 |
| Disease | Target Count | P-value |
|---|---|---|
| cutaneous lupus erythematosus | 1057 | 2.8e-03 |
| oligodendroglioma | 2850 | 3.6e-03 |
| psoriasis | 6694 | 3.9e-03 |
| ependymoma | 4679 | 4.2e-03 |
| pediatric high grade glioma | 1064 | 5.1e-03 |
| glioblastoma | 5792 | 5.5e-03 |
| astrocytic glioma | 2597 | 1.0e-02 |
| Polycystic ovary syndrome | 360 | 1.2e-02 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 3.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Glycine encephalopathy | 29 | 4.539 | 2.3 |
| Hyperekplexia | 16 | 3.323 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | 1.300 | 1.0e-02 |
| cutaneous lupus erythematosus | -1.200 | 2.8e-03 |
| ependymoma | 1.500 | 4.2e-03 |
| glioblastoma | 1.700 | 5.5e-03 |
| mucosa-associated lymphoid tissue lympho... | 1.150 | 3.8e-02 |
| oligodendroglioma | 1.300 | 3.6e-03 |
| pediatric high grade glioma | 1.300 | 5.1e-03 |
| Polycystic ovary syndrome | -1.035 | 1.2e-02 |
| psoriasis | -1.200 | 3.9e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
CHEMBL398398
pIC50 6.00
CHEMBL428386
pIC50 6.00
CHEMBL240031
pIC50 6.00
CHEMBL239999
pIC50 6.00
CHEMBL1834686
pIC50 6.00
CHEMBL3114963
pIC50 6.00
CHEMBL1834682
pIC50 6.00
CHEMBL64154
pIC50 6.00
CHEMBL377350
pEC50 6.01
CHEMBL377109
pEC50 6.01
CHEMBL62571
pIC50 6.01
CHEMBL399144
pIC50 6.02
CHEMBL250152
pIC50 6.02
CHEMBL209380
pEC50 6.02
CHEMBL213672
pEC50 6.02
CHEMBL213982
pIC50 6.02
CHEMBL1171648
pEC50 6.05
CHEMBL3114964
pIC50 6.05
CHEMBL3115207
pIC50 6.05
CHEMBL519701
pIC50 6.06
MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKVWHGAYNSGLL 1 - 70 PQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMF 71 - 140 PYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSS 141 - 210 MTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDI 211 - 280 GNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTP 281 - 350 QWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF 351 - 420 MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGN 421 - 490 EWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDI 491 - 560 QMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMF 561 - 630 RLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSR 631 - 700 LQDSRI 701 - 706 //
