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Tbio Sodium/myo-inositol cotransporter

Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.

 Comments

Property Summary

NCBI Gene PubMed Count 20
PubMed Score 40.41
PubTator Score 81.62

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Bipolar Disorder 666 0.0 0.0
Carcinoma, Renal Cell 124 0.0 0.0
Disease Target Count
Renal Cell Carcinoma 214
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.7
Disease Target Count Z-score Confidence
Down syndrome 499 3.64 1.8

Expression

  Differential Expression (29)

Disease log2 FC p
acute myeloid leukemia -1.200 3.6e-02
acute quadriplegic myopathy 1.477 4.3e-06
Alzheimer's disease 1.300 3.0e-02
astrocytic glioma 1.100 3.8e-03
atypical teratoid / rhabdoid tumor 1.300 8.5e-05
autosomal dominant Emery-Dreifuss muscul... 1.338 7.4e-03
Breast cancer 3.200 2.4e-02
ependymoma 1.600 2.9e-02
gastric cancer 1.100 1.6e-03
glioblastoma 1.200 1.7e-02
intraductal papillary-mucinous adenoma (... 1.100 2.2e-03
intraductal papillary-mucinous carcinoma... 1.400 1.7e-03
intraductal papillary-mucinous neoplasm ... 1.100 2.2e-02
invasive ductal carcinoma 1.052 4.3e-02
juvenile dermatomyositis 1.325 4.5e-11
lung adenocarcinoma 1.200 3.4e-04
lung cancer 1.900 6.2e-04
malignant mesothelioma 1.300 3.2e-05
medulloblastoma, large-cell 1.600 2.4e-04
non-small cell lung cancer 1.190 5.7e-11
osteosarcoma -2.855 2.5e-06
pancreatic cancer 1.100 3.3e-05
Pick disease 1.700 1.5e-04
progressive supranuclear palsy 1.700 3.4e-02
psoriasis 1.400 3.0e-03
sarcoidosis 1.300 2.6e-02
subependymal giant cell astrocytoma 1.391 3.5e-02
tuberculosis -1.300 1.2e-03
ulcerative colitis -1.217 1.9e-02

Synonym

Accession P53794 O43489 Na(+)/myo-inositol cotransporter
Symbols BCW2
SMIT
SMIT1
SMIT2

Gene

SLC5A3

PANTHER Protein Class (2)

  Ortholog (3)

Species Source Disease
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (13)

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 GO Function (2)

 GO Component (3)

 GO Process (5)

 Compartment GO Term (13)

 MGI Phenotype (5)

 HCA RNA Cell Line (56)

See all...

Pathway (5)

Gene RIF (10)

AA Sequence 

MRAVLDTADIAIVALYFILVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVTIGASLFVSNIGSEHFIGLAG      1 - 70
SGAASGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGHRIQVYFAALSLILYIFTKLS     71 - 140
VDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMIISIMEIGGF    141 - 210
EEVKRRYMLASPDVTSILLTYNLSNTNSCNVSPKKEALKMLRNPTDEDVPWPGFILGQTPASVWYWCADQ    211 - 280
VIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRILFTDDIACINPEHCMLVCGSRAGCSNIA    281 - 350
YPRLVMKLVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKLIRKSASSRELMIVGRIFVAFMVV    351 - 420
ISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVLGAVRLILAFA    421 - 490
YRAPECDQPDNRPGFIKDIHYMYVATGLFWVTGLITVIVSLLTPPPTKEQIRTTTFWSKKNLVVKENCSP    491 - 560
KEEPYQMQEKSILRCSENNETINHIIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASLGHSEAETPVDA    561 - 630
YSNGQAALMGEKERKKETDDGGRYWKFIDWFCGFKSKSLSKRSLRDLMEEEAVCLQMLEETRQVKVILNI    631 - 700
GLFAVCSLGIFMFVYFSL                                                        701 - 718
//

Text Mined References (21)

PMID Year Title