| Tbio | Sodium/myo-inositol cotransporter |
Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.
Comments
| Disease | Target Count |
|---|---|
| Down syndrome | 548 |
| Bipolar Disorder | 266 |
| Muscle Weakness | 92 |
| Renal Cell Carcinoma | 199 |
| PMID | Text | |
|---|---|---|
| 25756525 | Hypotonic stress causes a significant upregulation of SLC5A3 gene expression as detected by semiquantitative RT-PCR and Western blot analysis. | |
| 24944204 | A kinetic model has been generated for the transport mechanism of SMIT2 allowing insight into the transport of members of the LeuT structural family at the millisecond timescale. | |
| 23207989 | JAK2 contributes to the regulation of the myoinositol transporter SMIT. | |
| 20971364 | Observational study of gene-disease association. (HuGE Navigator) | |
| 20738937 | Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | |
| 19198609 | Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | |
| 19032932 | Expression and/or function of SMIT2 may be reduced in diabetes mellitus, insulin resistance and polycystic ovary syndrome causing abnormal inositol meteabolism | |
| 17178845 | Tumor cells silence SLC5A8 and convert pyruvate into lactate as complementary mechanisms to avoid pyruvate-induced cell death. |
MRAVLDTADIAIVALYFILVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVTIGASLFVSNIGSEHFIGLAG 1 - 70 SGAASGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGHRIQVYFAALSLILYIFTKLS 71 - 140 VDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMIISIMEIGGF 141 - 210 EEVKRRYMLASPDVTSILLTYNLSNTNSCNVSPKKEALKMLRNPTDEDVPWPGFILGQTPASVWYWCADQ 211 - 280 VIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRILFTDDIACINPEHCMLVCGSRAGCSNIA 281 - 350 YPRLVMKLVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKLIRKSASSRELMIVGRIFVAFMVV 351 - 420 ISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVLGAVRLILAFA 421 - 490 YRAPECDQPDNRPGFIKDIHYMYVATGLFWVTGLITVIVSLLTPPPTKEQIRTTTFWSKKNLVVKENCSP 491 - 560 KEEPYQMQEKSILRCSENNETINHIIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASLGHSEAETPVDA 561 - 630 YSNGQAALMGEKERKKETDDGGRYWKFIDWFCGFKSKSLSKRSLRDLMEEEAVCLQMLEETRQVKVILNI 631 - 700 GLFAVCSLGIFMFVYFSL 701 - 718 //
| PMID | Year | Title | |
|---|---|---|---|
| 25756525 | 2015 | Hypotonic activation of the myo-inositol transporter SLC5A3 in HEK293 cells probed by cell volumetry, confocal and super-resolution microscopy. | |
| 24944204 | 2014 | The transport mechanism of the human sodium/myo-inositol transporter 2 (SMIT2/SGLT6), a member of the LeuT structural family. | |
| 23207989 | 2012 | Down-regulation of the myoinositol transporter SMIT by JAK2. | |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. | |
| 20971364 | 2010 | A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. | |
| 20738937 | 2010 | Additive effect of multiple genetic variants on the risk of coronary artery disease. | |
| 19198609 | 2009 | Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. | |
| 19032932 | 2009 | Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. | |
| 17178845 | 2006 | SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases. | |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | |
| 15342556 | 2004 | Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 10830953 | 2000 | The DNA sequence of human chromosome 21. | |
| 9685419 | 1998 | Transcription of the sodium/myo-inositol cotransporter gene is regulated by multiple tonicity-responsive enhancers spread over 50 kilobase pairs in the 5'-flanking region. | |
| 9612208 | 1998 | Human Na(+)-myo-inositol cotransporter gene: alternate splicing generates diverse transcripts. | |
| 9441750 | 1997 | The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter. | |
| 8646889 | 1996 | The 21q22.1 STS marker, VN02 (EST00541 cDNA), is part of the 3' sequence of the human Na+/myo-inositol cotransporter (SLC5A3) gene. | |
| 7789985 | 1995 | The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21. | |
| 1372904 | 1992 | Cloning of the cDNa for a Na+/myo-inositol cotransporter, a hypertonicity stress protein. |
