Property Summary

NCBI Gene PubMed Count 16
PubMed Score 81.85
PubTator Score 23.20

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count
Cholestasis 93
Biliary cirrhosis 33
Disease Target Count P-value
osteosarcoma 7933 4.1e-06
ulcerative colitis 2087 3.6e-04
active Crohn's disease 918 1.0e-03
Disease Target Count Z-score Confidence
Osteoporosis 259 5.23 2.6

Expression

  Differential Expression (3)

Disease log2 FC p
osteosarcoma -2.330 4.1e-06
active Crohn's disease -4.085 1.0e-03
ulcerative colitis -3.600 3.6e-04

Gene RIF (12)

PMID Text
24703425 Hepatic OSTalpha-OSTbeta expression is induced by hypoxia.
22535958 Ostbeta is required for both proper trafficking of Ostalpha and formation of the functional transport unit, and identify specific residues of Ostbeta critical for these processes.
22404213 Knockdown of organic solute transporter alpha (OSTalpha) by siRNA enhances HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells
21691099 The present report summarizes the evidence for a pleiotropic role of Ostalpha-Ostbeta in different tissues.
18847488 human OSTalpha is a glycoprotein that requires interaction with OSTbeta to reach the plasma membrane. However, glycosylation of OSTalpha is not necessary for interaction with the beta subunit or for membrane localization .
18469300 The mRNA expression of OSTalpha-OSTbeta was significantly reduced (OSTalpha: 3.3-fold, P = 0.006; OSTbeta: 2.6-fold, P = 0.03) in normal-weight but not overweight gallstone carriers
17332473 Demonstrate association of OST-alpha and OST-beta to determine trafficking to plasma membrane and activity.
16423920 These results indicate that expression of Ostalpha and Ostbeta are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor.
16317684 the selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.
16269519 OSTalpha/OSTbeta expression is induced by bile acids through ligand-dependent transactivation of both OST genes by the nuclear bile acid receptor/farnesoid X receptor (FXR).
16251721 overexpression of human OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate and the activation of FXR target genes
12719432 OSTalpha has roles in biological transport and is widely expressed in human tissues

AA Sequence

MEPGRTQIKLDPRYTADLLEVLKTNYGIPSACFSQPPTAAQLLRALGPVELALTSILTLLALGSIAIFLE      1 - 70
DAVYLYKNTLCPIKRRTLLWKSSAPTVVSVLCCFGLWIPRSLVLVEMTITSFYAVCFYLLMLVMVEGFGG     71 - 140
KEAVLRTLRDTPMMVHTGPCCCCCPCCPRLLLTRKKLQLLMLGPFQYAFLKITLTLVGLFLVPDGIYDPA    141 - 210
DISEGSTALWINTFLGVSTLLALWTLGIISRQARLHLGEQNMGAKFALFQVLLILTALQPSIFSVLANGG    211 - 280
QIACSPPYSSKTRSQVMNCHLLILETFLMTVLTRMYYRRKDHKVGYETFSSPDLDLNLKA              281 - 340
//

Text Mined References (17)

PMID Year Title
24816252 2014 An atlas of genetic influences on human blood metabolites.
24703425 2015 The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes.
22535958 2012 ?-Subunit of the Ost?-Ost? organic solute transporter is required not only for heterodimerization and trafficking but also for function.
21691099 2011 Pleiotropic functions of the organic solute transporter Ost?-Ost?.
20538072 2010 Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism.
18847488 2008 N-Glycosylation of the alpha subunit does not influence trafficking or functional activity of the human organic solute transporter alpha/beta.
18469300 2008 Reduced ileal expression of OSTalpha-OSTbeta in non-obese gallstone disease.
17332473 2007 Protein-protein interactions and membrane localization of the human organic solute transporter.
16713569 2006 A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
16423920 2006 Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.
16317684 2005 OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia.
16269519 2006 The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes.
16251721 2006 FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.
15563450 2005 The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12719432 2003 Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.