SLC45A2
Membrane-associated transporter protein
Protein Summary
Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity). This gene encodes a transporter protein that mediates melanin synthesis. The protein is expressed in a high percentage of melanoma cell lines. Mutations in this gene are a cause of oculocutaneous albinism type 4, and polymorphisms in this gene are associated with variations in skin and hair color. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
- ENST00000296589
- ENSP00000296589
- ENSG00000164175
- ENST00000382102
- ENSP00000371534
- AIM1
- MATP
- 1A1
- AIM1
- MATP
- OCA4
- SHEP5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.99 | ||
trait | 0.86 | ||
cell type or tissue | 0.76 | ||
phenotype | 0.63 | ||
biological term | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 462.34 (req: < 5)
Gene RIFs: 54 (req: <= 3)
Antibodies: 104 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 462.34 (req: >= 5)
Gene RIFs: 54 (req: > 3)
Antibodies: 104 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0