Tbio SLC38A3 Sodium-coupled neutral amino acid transporter 3

Protein Summary

Description

Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.

Uniprot Accession IDs

• Q99624
• B2R8Q0
• Q6IB34

Gene Name

• SLC38A3

Ensembl ID

• ENST00000614032
• ENSP00000481301
• ENSG00000188338

Symbol

• G17
• NAT1
• SN1
• SNAT3
• G17
• SN1
• NAT1
• SNAT3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.91
transcription factor perturbation	0.68
transcription factor	0.65
tissue	0.62
PubMedID	0.59

Protein Classes

PANTHER Classes

Protein / Transporter / Amino Acid Transporter / Sodium-coupled Neutral Amino Acid Transporter 3

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc38 Family Of Sodium-dependent Neutral Amino Acid Transporters / System N-like Transporters / Sodium-coupled Neutral Amino Acid Transporter 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1446.21   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1446.21   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0