Property Summary

NCBI Gene PubMed Count 19
PubMed Score 10.75
PubTator Score 10.24

Knowledge Summary


No data available


  Differential Expression (1)

Disease log2 FC p
malignant mesothelioma -1.300 1.3e-06

Protein-protein Interaction (2)

Gene RIF (7)

25239688 two Turkish siblings with a novel mutation in GDP-fucose transporter and features of congenital disorder of glycosylation IIc
23730929 Fx enzyme and GDP-L-Fuc Tr overexpression in the tumur tissue of colorectal cancer (CRC) patients suggests that GDP-L-Fuc transport to the Golgi apparatus may be an important factor associated with increased alpha(1,6)fucosylation in CRC.
22492235 the conserved glycine residues at positions 180 and 277 of SLC35C1 have significant impacts on lectin binding
22134107 In the rare LAD-II disease, the fucosylation of selectin ligands is disturbed, caused by mutations in SLC35C1, the gene that encodes a GDP-fucose transporter of the Golgi system. (Review)
17884843 the upregulation of GDP-Fuc Tr plays a pivotal role in increased fucosylation in hepatocellular carcinoma
16455955 Leukocyte adhesion deficiency II patients display dual defect in functoin ang Golgi expression of FUCT1.
12406889 In the GDP-fucose transporter a new single nucleotide deletion produced an open-reading frame shift & polypeptide truncation. Overexpression of the mutant protein in fibroblasts did not rescue fucosylation. The deletion ablated transporter activity.

AA Sequence

EPSPKDSEKSAMGV                                                            351 - 364

Text Mined References (19)

PMID Year Title
25239688 2014 A novel mutation in leukocyte adhesion deficiency type II/CDGIIc.
24144296 2013 Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
23730929 2013 FX enzyme and GDP-L-Fuc transporter expression in colorectal cancer.
22589738 2012 Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
22492235 2012 Identification of functional elements of the GDP-fucose transporter SLC35C1 using a novel Chinese hamster ovary mutant.
22134107 2012 Hematologically important mutations: leukocyte adhesion deficiency (first update).
22020285 2011 Image-based genome-wide siRNA screen identifies selective autophagy factors.
17884843 2007 A high expression of GDP-fucose transporter in hepatocellular carcinoma is a key factor for increases in fucosylation.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16554811 2006 Human chromosome 11 DNA sequence and analysis including novel gene identification.
16455955 2006 Leukocyte adhesion deficiency II patients with a dual defect of the GDP-fucose transporter.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12406889 2003 Insights into leukocyte adhesion deficiency type 2 from a novel mutation in the GDP-fucose transporter gene.
11326280 2001 Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency.
11326279 2001 The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.