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Tchem
SLC33A1
Acetyl-coenzyme A transporter 1

Protein Summary
Description
Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides (PubMed:9096318). Negatively regulates BMP signaling (PubMed:25402622). The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family, but not in similar patients of European descent. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359479
  • ENSP00000352456
  • ENSG00000169359
  • ENST00000392845
  • ENSP00000376587
  • ENST00000643144
  • ENSP00000496241

Symbol
  • ACATN
  • AT1
  • AT1
  • AT-1
  • ACATN
  • SPG42
  • CCHLND
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
transcription factor binding site profile
0.92
transcription factor
0.76
tissue sample
0.75
microRNA
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.05   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.05   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 143
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0