Tbio SLC31A1 High affinity copper uptake protein 1

Protein Summary

Description

High-affinity, saturable copper transporter involved in dietary copper uptake. The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• O15431
• A8K8Z6
• Q53GR5
• Q5T1M4

Gene Name

• SLC31A1

Ensembl ID

• ENST00000374212
• ENSP00000363329
• ENSG00000136868

Symbol

• COPT1
• CTR1
• CTR1
• COPT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
histone modification site profile	0.89
transcription factor perturbation	0.88
cell type or tissue	0.79
transcription factor	0.7

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc31 Family Of Copper Transporters / High Affinity Copper Uptake Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.15   (req: < 5)

Gene RIFs: 73   (req: <= 3)

Antibodies: 220   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.15   (req: >= 5)

Gene RIFs: 73   (req: > 3)

Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0