| Tbio | Zinc transporter 4 |
Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment.
Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]
Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Alzheimer Disease | 83 | 0.0 | 0.0 |
| Respiratory Hypersensitivity | 19 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Alzheimer's disease | 658 |
| Schizophrenia, Catatonic | 4 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 1.2e-16 |
| malignant mesothelioma | 3232 | 1.2e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.9e-06 |
| medulloblastoma, large-cell | 6241 | 4.1e-06 |
| ulcerative colitis | 1819 | 7.2e-05 |
| glioblastoma | 5792 | 7.9e-05 |
| adult high grade glioma | 3801 | 8.5e-04 |
| medulloblastoma | 720 | 8.7e-04 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.2e-03 |
| primitive neuroectodermal tumor | 3035 | 1.6e-03 |
| lung cancer | 4740 | 1.1e-02 |
| astrocytic glioma | 2597 | 1.6e-02 |
| ependymoma | 4679 | 1.7e-02 |
| colon cancer | 1478 | 2.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Acrodermatitis enteropathica | 18 | 5.927 | 3.0 |
| Ileocolitis | 5 | 3.168 | 1.6 |
| Acrodermatitis | 5 | 3.041 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.400 | 8.5e-04 |
| astrocytic glioma | -1.500 | 1.6e-02 |
| atypical teratoid / rhabdoid tumor | -1.800 | 1.9e-06 |
| colon cancer | -1.500 | 2.5e-02 |
| ependymoma | -2.000 | 1.7e-02 |
| glioblastoma | -1.100 | 7.9e-05 |
| lung cancer | -1.200 | 1.1e-02 |
| malignant mesothelioma | -2.200 | 1.2e-07 |
| medulloblastoma | -1.100 | 8.7e-04 |
| medulloblastoma, large-cell | -3.100 | 4.1e-06 |
| ovarian cancer | -4.100 | 1.2e-16 |
| pancreatic ductal adenocarcinoma liver m... | -1.025 | 1.2e-03 |
| primitive neuroectodermal tumor | -1.400 | 1.6e-03 |
| ulcerative colitis | -1.300 | 7.2e-05 |
MAGSGAWKRLKSMLRKDDAPLFLNDTSAFDFSDEAGDEGLSRFNKLRVVVADDGSEAPERPVNGAHPTLQ 1 - 70 ADDDSLLDQDLPLTNSQLSLKVDSCDNCSKQREILKQRKVKARLTIAAVLYLLFMIGELVGGYIANSLAI 71 - 140 MTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRLEVLSAMISVLLVYILMGFLLYEAVQRTIHMN 141 - 210 YEINGDIMLITAAVGVAVNVIMGFLLNQSGHRHSHSHSLPSNSPTRGSGCERNHGQDSLAVRAAFVHALG 211 - 280 DLVQSVGVLIAAYIIRFKPEYKIADPICTYVFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKEALMK 281 - 350 IEDVYSVEDLNIWSLTSGKSTAIVHIQLIPGSSSKWEEVQSKANHLLLNTFGMYRCTIQLQSYRQEVDRT 351 - 420 CANCQSSSP 421 - 429 //
