| Tbio | Solute carrier family 25 member 46 |
May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission.
This gene encodes a mitochondrial solute carrier protein family member. It functions in promoting mitochondrial fission, and prevents the formation of hyperfilamentous mitochondria. Mutation of this gene results in neuropathy and optic atrophy. [provided by RefSeq, Aug 2016]
This gene encodes a mitochondrial solute carrier protein family member. It functions in promoting mitochondrial fission, and prevents the formation of hyperfilamentous mitochondria. Mutation of this gene results in neuropathy and optic atrophy. [provided by RefSeq, Aug 2016]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Optic Atrophy | 242 | 3.871 | 1.9 |
| Charcot-Marie-Tooth disease | 62 | 0.0 | 4.0 |
| NEUROPATHY, HEREDITARY MOTOR AND SENSORY, TYPE VIB | 1 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Hereditary motor and sensory neuropathy with optic atrophy (disorder) | 2 |
| Disease | Target Count | P-value |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 5112 | 6.2e-07 |
| Pick disease | 1894 | 3.2e-05 |
| ovarian cancer | 8520 | 6.9e-05 |
| Multiple myeloma | 1332 | 1.7e-03 |
| hereditary spastic paraplegia | 318 | 4.0e-03 |
| progressive supranuclear palsy | 676 | 2.3e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.8e-02 |
| Alzheimer's disease | 658 | 3.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Allergic rhinitis | 94 | 0.0 | 3.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Neurodegenerative disease | 414 | 0.0 | 4.0 |
| Neuropathy | 261 | 0.0 | 4.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| tuberculosis | 2010 | 5.873 | 2.9 |
| Laryngeal tuberculosis | 3 | 4.063 | 2.0 |
| Pontocerebellar hypoplasia | 36 | 4.001 | 2.0 |
| Ancylostomiasis | 6 | 3.739 | 1.9 |
| Leprosy | 73 | 3.044 | 1.5 |
| Disease | Target Count |
|---|---|
| Neuropathy, Hereditary Motor and Sensory, Type 6B | 1 |
| Disease | log2 FC | p |
|---|---|---|
| Alzheimer's disease | -1.200 | 3.0e-02 |
| atypical teratoid / rhabdoid tumor | -1.600 | 6.2e-07 |
| hereditary spastic paraplegia | -1.139 | 4.0e-03 |
| Multiple myeloma | 1.745 | 1.7e-03 |
| ovarian cancer | -1.700 | 6.9e-05 |
| pancreatic ductal adenocarcinoma liver m... | -1.552 | 2.8e-02 |
| Pick disease | -1.500 | 3.2e-05 |
| progressive supranuclear palsy | -1.400 | 2.3e-02 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MHPRRPDGFDGLGYRGGARDEQGFGGAFPARSFSTGSDLGHWVTTPPDIPGSRNLHWGEKSPPYGVPTTS 1 - 70 TPYEGPTEEPFSSGGGGSVQGQSSEQLNRFAGFGIGLASLFTENVLAHPCIVLRRQCQVNYHAQHYHLTP 71 - 140 FTVINIMYSFNKTQGPRALWKGMGSTFIVQGVTLGAEGIISEFTPLPREVLHKWSPKQIGEHLLLKSLTY 141 - 210 VVAMPFYSASLIETVQSEIIRDNTGILECVKEGIGRVIGMGVPHSKRLLPLLSLIFPTVLHGVLHYIISS 211 - 280 VIQKFVLLILKRKTYNSHLAESTSPVQSMLDAYFPELIANFAASLCSDVILYPLETVLHRLHIQGTRTII 281 - 350 DNTDLGYEVLPINTQYEGMRDCINTIRQEEGVFGFYKGFGAVIIQYTLHAAVLQITKIIYSTLLQNNI 351 - 418 //
