Property Summary

NCBI Gene PubMed Count 17
PubMed Score 29.44
PubTator Score 21.37

Knowledge Summary


No data available


  Disease (3)

Disease Target Count P-value
non primary Sjogren syndrome sicca 840 1.9e-02
Disease Target Count Z-score Confidence
Testicular cancer 24 0.0 1.0
Disease Target Count Z-score Confidence
Strongyloidiasis 9 3.945 2.0


  Differential Expression (1)

Disease log2 FC p
non primary Sjogren syndrome sicca -1.200 1.9e-02

Gene RIF (7)

23266187 Compares and contrasts all the known human SLC25A* genes and includes functional information.
21827840 Data show the specific role of the ANT4 isoform in spermatozoid bioenergetics.
21532989 data define common and distinct biochemical characteristics of ANT4 in comparison to ANT1, 2 and 3 providing a basis for study of its unique adaptation to germ cells
20877624 Observational study of gene-disease association. (HuGE Navigator)
20060930 data highlight a cytoprotective activity of ANT4, and provide a novel dichotomy in the ANT isoform sub-family with ANT1 and 3 isoforms functioning as pro-apoptotic while ANT2 and 4 isoforms render cells resistant to death inducing stimuli
19556438 Male mice with disruptions of Slc25a31 are sterile and display an early meiotic arrest phenotype.
17137571 The co-localization of SFEC and glycolytic enzymes in the fibrous sheath supports a growing literature that the principal piece of the flagellum is capable of generating and regulating ATP independently from mitochondrial oxidation in the mid-piece.

AA Sequence

FRGAFSNVLRGTGGALVLVLYDKIKEFFHIDIGGR                                       281 - 315

Text Mined References (20)

PMID Year Title
25787250 2015 Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.
23266187 The mitochondrial transporter family SLC25: identification, properties and physiopathology.
21827840 2011 Computational analysis of the transcriptional regulation of the adenine nucleotide translocator isoform 4 gene and its role in spermatozoid glycolytic metabolism.
21630459 2011 Proteomic characterization of the human sperm nucleus.
21532989 2011 Functional expression of human adenine nucleotide translocase 4 in Saccharomyces cerevisiae.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
20060930 2010 The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells.
19556438 2009 Adenine nucleotide translocase 4 deficiency leads to early meiotic arrest of murine male germ cells.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17137571 2007 Compartmentalization of a unique ADP/ATP carrier protein SFEC (Sperm Flagellar Energy Carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece.
16381901 2006 The LIFEdb database in 2006.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15670820 2005 A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution.
15489336 2004 From ORFeome to biology: a functional genomics pipeline.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11329013 2001 Creation of genome-wide protein expression libraries using random activation of gene expression.
11256614 2000 Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.
11230166 2001 Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
11076863 2000 DNA cloning using in vitro site-specific recombination.