Property Summary

NCBI Gene PubMed Count 20
PubMed Score 27.99
PubTator Score 24.50

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (10)

Disease log2 FC p
astrocytic glioma -1.200 1.7e-02
psoriasis -1.300 1.2e-03
osteosarcoma -1.774 4.3e-06
atypical teratoid / rhabdoid tumor -1.300 4.2e-07
glioblastoma -1.400 9.7e-06
medulloblastoma -1.100 1.0e-03
medulloblastoma, large-cell -1.200 4.9e-05
adult high grade glioma -1.200 3.6e-04
subependymal giant cell astrocytoma -1.310 4.0e-02
ovarian cancer 1.300 1.5e-03

Gene RIF (10)

PMID Text
23266757 Increased expression of cerebral UCP5 and UCP4 is observed in a model of high altitude hypoxia and mitochondrial oxidative phosphorylation deficiency.
23266187 Compares and contrasts all the known human SLC25A* genes and includes functional information.
22524567 Neuronal UCP5 exhibits transmembrane chloride transport activity.
22087257 observed significant associations between genetic variants in the SIRT6 and UCP5 genes and atherosclerotic plaque
19910678 The enhanced level of UCP5 is associated to mitochondrial dysfunction in colonic cells.
18018477 The brain may respond to neuroprotection through the increased expression of UCP5 under ischemic conditions.
17066476 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17066476 These findings suggest that UCP2 and UCP4 have a modest but important involvement in the genetic etiology of schizophrenia.
16941493 UCP5 might be physiologically important in the pathology of oxidative stress-induced neurodegeneration
12051969 expressed in skeletal muscle as three different isoforms; expression level of UCP5SI positively correlated with resting metabolic rate and lipid oxidation rate during a euglycemic clamp with infusion of insulin at a physiologic concentration

AA Sequence

MGIFPGIILIFLRVKFATAAVIVSGHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQV      1 - 70
QGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDET     71 - 140
LLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIV    141 - 210
VGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTV    211 - 280
DGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRLQI                             281 - 325
//

Text Mined References (20)

PMID Year Title
23266757 2013 Evidence for involvement of uncoupling proteins in cerebral mitochondrial oxidative phosphorylation deficiency of rats exposed to 5,000 m high altitude.
23266187 The mitochondrial transporter family SLC25: identification, properties and physiopathology.
23116158 2012 Brain region-specific altered expression and association of mitochondria-related genes in autism.
22950050 2012 Human neuronal uncoupling proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation, and physiological role in protection against oxidative stress and mitochondrial dysfunction.
22524567 2012 Toward understanding the mechanism of ion transport activity of neuronal uncoupling proteins UCP2, UCP4, and UCP5.
22087257 2011 Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque.
19910678 2009 Hydrogen peroxide regulates the mitochondrial content of uncoupling protein 5 in colon cancer cells.
18018477 2007 Amplified expression of uncoupling proteins in human brain ischemic lesions.
17066476 2007 Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia.
16941493 2006 Knockdown of uncoupling protein-5 in neuronal SH-SY5Y cells: Effects on MPP+-induced mitochondrial membrane depolarization, ATP deficiency, and oxidative cytotoxicity.
15772651 2005 The DNA sequence of the human X chromosome.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12051969 2002 UCP5/BMCP1 transcript isoforms in human skeletal muscle: relationship of the short-insert isoform with lipid oxidation and resting metabolic rates.
11701769 2001 BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production.
10928996 2000 Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation.
10772343 2000 Specific sequence of motifs of mitochondrial uncoupling proteins.
10620491 2000 The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP.
9852133 1998 BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast.