Tbio SLC24A3 Sodium/potassium/calcium exchanger 3

Protein Summary

Description

Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 [PubMed 11294880]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9HC58
• B1AKV7
• Q9BQJ9
• Q9BQL7
• Q9BQY3
• Q9H519

Gene Name

• SLC24A3

Ensembl ID

• ENST00000328041
• ENSP00000333519
• ENSG00000185052
• ENST00000613834
• ENSP00000482967

Symbol

• NCKX3
• NCKX3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
molecular function	0.79
disease perturbation	0.74
gene perturbation	0.74
disease	0.72

Protein Classes

PANTHER Classes

Protein / Transporter / Sodium/potassium/calcium Exchanger 3

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc24 Family Of Sodium/potassium/calcium Exchangers / Sodium/potassium/calcium Exchanger 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.27   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 104   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.27   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0