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Tchem Solute carrier family 22 member 9

Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes.

 Comments

Property Summary

NCBI Gene PubMed Count 16
PubMed Score 27.77
PubTator Score 9.84

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
psoriasis 6685 6.3e-11
Disease Target Count Z-score Confidence
Hyperuricemia 35 3.25 1.6

Expression

  Differential Expression (1)

Disease log2 FC p
psoriasis -2.300 6.3e-11

Synonym

Accession Q8IVM8 A0AVB7 A4PB24 Q8TCC8 Q8TEC0 Q8WYN7
Symbols OAT4
OAT7
ust3
HOAT4
UST3H

Gene

SLC22A9

PANTHER Protein Class (2)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (10)

 GO Function (4)

 GO Component (2)

 GO Process (3)

 Compartment GO Term (16)

See all...

 GWAS Trait (1)

 HCA RNA Cell Line (49)

See all...

Pathway (3)

Protein-protein Interaction (65)

LMBR1   MBOAT7   SLC46A1   TMEM87A   TM9SF2   SLC9A6   SYNGR2   FLVCR1   INPPL1   CAV1   SLC22A5   MANEAL   SLC35B2   SACM1L   GHITM   ELOVL2   SLC29A1   CDS1   ELOVL5   B3GAT3   FITM2   TMEM67   YIPF4   GPR89A   SLC35F5   APOB   SLC25A51   TMEM115   ZDHHC6   ALG10   SC5D   TMEM242   ORMDL2   ORMDL3   ORMDL1   PIGW   NDUFB3   DPY19L1   ZDHHC21   SLC19A2   TMPPE   ARV1   KDELR3   CHPT1   MFSD5   SERINC1   EXTL2   ARL6IP5   SLC16A10   TMEM56   WRB   SURF4   ATP9A   TMEM184B   MFSD12   MT-CO1   DSG4   MTX3   ALG8   SLC26A2   SLC25A46   SGPP1   MFSD8   RAB4A   C20orf24  

Ligand (1)

Structure of CHEMBL388978

CHEMBL388978
pIC50 9.00

Gene RIF (9)

PMID Text
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19371258 Human organic anion transporter hOAT4 is a transporter of perfluorooctanoic acid.
18501590 Functional differences in steroid uptake of SLC22A9 and SLC02B1 in human placenta are reported.
18466105 Review summarizes current knowledge on the functional and phenotypic consequences of genetic variation in intestinally, hepatically and renally expressed members of solute carrier family (SLC22) member 9.
18414781 The regulatory single nucleotide polymorphism (SNP) of OAT4 found in the promoter region of nephrectomized patients is unlikely to influence mRNA expression or promoter activity of OAT4.
18365245 The data provide a model for the concerted action of OAT1 mediating apical secretion of glutarate derivatives from proximal tubule cells
17393504 OAT7 is the first liver-specific transporter among members of the organic anion transporters of SLC22 family.
17341544 Both progesterone and activation of PKC inhibited hOAT4 activity through redistribution of the transporter from cell surface to the intracellular compartments.
12409283 uptake of steroid sulfates by isolated trophoblasts is mediated by OATP-B and OAT-4 suggesting a physiological role of both carrier proteins in placental uptake of fetal-derived steroid sulfates.

AA Sequence 

MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDNDTGALSQD      1 - 70
ALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGWVYDRISFSSTIVTEWDLVCD     71 - 140
SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAA    141 - 210
MSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLL    211 - 280
ESARWLIINNKPEEGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKR    281 - 350
ISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAIC    351 - 420
LLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMIL    421 - 490
SVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPREPKQEDPRVEVTQF           491 - 553
//

Text Mined References (18)

PMID Year Title
22566634 2012 The genetic architecture of economic and political preferences.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19371258 2009 Human organic anion transporter hOAT4 is a transporter of perfluorooctanoic acid.
18501590 2008 Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) and organic anion transporting polypeptide 2B1 (OATP2B1) in human placenta.
18466105 2008 Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney.
18414781 2008 Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney.
18365245 2008 Organic anion transporters OAT1 and OAT4 mediate the high affinity transport of glutarate derivatives accumulating in patients with glutaric acidurias.
17393504 2007 Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate.
17341544 2007 Regulation of human organic anion transporter 4 by progesterone and protein kinase C in human placental BeWo cells.
16959974 2006 The consensus coding sequences of human breast and colorectal cancers.
16554811 2006 Human chromosome 11 DNA sequence and analysis including novel gene identification.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15037815 2004 Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12409283 2003 Characterization and identification of steroid sulfate transporters of human placenta.
11327718 2001 Isolation of a family of organic anion transporters from human liver and kidney.
10660625 2000 Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta.