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Tbio Solute carrier family 22 member 9

Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes.

 Comments

Property Summary

NCBI Gene PubMed Count 17
PubMed Score 30.49
PubTator Score 9.84

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count P-value
psoriasis 6694 6.3e-11
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8
Disease Target Count Z-score Confidence
Gout 106 4.046 2.0
Hyperuricemia 49 4.006 2.0

Expression

  Differential Expression (1)

Disease log2 FC p
psoriasis -2.300 6.3e-11

Synonym

Accession Q8IVM8 A0AVB7 A4PB24 Q8TCC8 Q8TEC0 Q8WYN7
Symbols OAT4
OAT7
ust3
HOAT4
UST3H

Gene

SLC22A9

  Ortholog (4)

Species Source Disease
OMA EggNOG
OMA EggNOG
OMA EggNOG
OMA EggNOG

 UniProt Keyword (10)

 GO Function (5)

 GO Component (2)

 GO Process (4)

 Compartment GO Term (16)

See all...

 GWAS Trait (1)

 HCA RNA Cell Line (49)

See all...

Protein-protein Interaction (65)

LMBR1   MBOAT7   SLC46A1   TMEM87A   TM9SF2   SLC9A6   SYNGR2   FLVCR1   INPPL1   CAV1   SLC22A5   MANEAL   SLC35B2   SACM1L   GHITM   ELOVL2   SLC29A1   CDS1   ELOVL5   B3GAT3   FITM2   TMEM67   YIPF4   GPR89A   SLC35F5   APOB   SLC25A51   TMEM115   ZDHHC6   ALG10   SC5D   TMEM242   ORMDL2   ORMDL3   ORMDL1   PIGW   NDUFB3   DPY19L1   ZDHHC21   SLC19A2   TMPPE   ARV1   KDELR3   CHPT1   MFSD5   SERINC1   EXTL2   ARL6IP5   SLC16A10   TMEM56   WRB   SURF4   ATP9A   TMEM184B   MFSD12   MT-CO1   DSG4   MTX3   ALG8   SLC26A2   SLC25A46   SGPP1   MFSD8   RAB4A   C20orf24  

Gene RIF (10)

AA Sequence 

MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDNDTGALSQD      1 - 70
ALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGWVYDRISFSSTIVTEWDLVCD     71 - 140
SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAA    141 - 210
MSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLL    211 - 280
ESARWLIINNKPEEGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKR    281 - 350
ISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAIC    351 - 420
LLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMIL    421 - 490
SVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPREPKQEDPRVEVTQF           491 - 553
//

Text Mined References (19)

PMID Year Title