Tchem | Excitatory amino acid transporter 3 |
This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]
Comments
Property Summary
Ligand Count | 23 |
NCBI Gene PubMed Count | 95 |
PubMed Score | 395.60 |
PubTator Score | 234.66 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Epilepsy | 792 | 4.352 | 2.2 |
Schizophrenia | 1160 | 4.091 | 2.0 |
Low tension glaucoma | 7 | 3.847 | 1.9 |
Atrophy | 10 | 0.0 | 0.0 |
Brain Diseases | 24 | 0.0 | 0.0 |
Cognition Disorders | 32 | 0.0 | 0.0 |
Endometriosis | 540 | 0.0 | 0.0 |
Epilepsy, Temporal Lobe | 23 | 0.0 | 0.0 |
Malformations of Cortical Development | 13 | 0.0 | 0.0 |
Nerve Degeneration | 121 | 0.0 | 0.0 |
Retinal Degeneration | 106 | 0.0 | 0.0 |
Seizures | 596 | 0.0 | 0.0 |
Disease | Target Count |
---|---|
Atrophic | 10 |
Bipolar Disorder | 666 |
Depressive disorder | 409 |
Dicarboxylicaminoaciduria | 1 |
Mental Depression | 333 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
obsessive-compulsive disorder | 61 | 5.768 | 2.9 |
Amyotrophic lateral sclerosis | 451 | 3.828 | 1.9 |
Toxic encephalopathy | 141 | 3.412 | 1.7 |
Chronic tic disorder | 8 | 3.166 | 1.6 |
Parkinson's disease | 392 | 3.1 | 1.6 |
Vascular disease | 319 | 3.018 | 1.5 |
Disease | Target Count |
---|---|
Dicarboxylic aminoaciduria | 4 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |
CHEMBL425569
pIC50 6.00
CHEMBL373283
pIC50 6.00
CHEMBL198315
pIC50 6.00
CHEMBL446256
pKi 6.00
CHEMBL2113126
pIC50 6.07
CHEMBL2113117
pIC50 6.19
CHEMBL424838
pIC50 6.22
CHEMBL2113123
pIC50 6.22
CHEMBL2113113
pIC50 6.22
CHEMBL2113122
pIC50 6.30
CHEMBL2113118
pIC50 6.35
CHEMBL1628570
pIC50 6.38
CHEMBL2113111
pIC50 6.52
CHEMBL1257519
pIC50 6.52
CHEMBL2113116
pIC50 6.70
CHEMBL2113112
pIC50 6.85
CHEMBL575060
pKi 7.29
CHEMBL2113115
pIC50 7.30
DL-TBOA
pIC50 5.10
L-β-BA
pKi 6.10
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPL 1 - 70 IISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVD 71 - 140 AMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKEYKIVGMYSDGI 141 - 210 NVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFR 211 - 280 KLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQV 281 - 350 DKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMV 351 - 420 IVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALEST 421 - 490 ILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF 491 - 524 //