| Tchem | Folate transporter 1 |
The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Comments
Property Summary
| Ligand Count | 15 |
| NCBI Gene PubMed Count | 166 |
| PubMed Score | 97.75 |
| PubTator Score | 217.80 |
| Disease | Target Count |
|---|---|
| Malignant mesothelioma of pleura | 7 |
| non-small cell lung cancer | 2890 |
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3578 | 1.8e-14 |
| osteosarcoma | 7950 | 2.1e-10 |
| tuberculosis | 2010 | 7.8e-07 |
| ovarian cancer | 8520 | 7.9e-07 |
| malignant mesothelioma | 3232 | 1.1e-05 |
| sonic hedgehog group medulloblastoma | 467 | 3.8e-04 |
| adult high grade glioma | 3801 | 4.2e-04 |
| psoriasis | 6694 | 5.0e-04 |
| medulloblastoma, large-cell | 6241 | 6.1e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.5e-03 |
| active Crohn's disease | 922 | 2.9e-03 |
| active ulcerative colitis | 764 | 3.7e-03 |
| colon cancer | 1478 | 5.0e-02 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | -1.144 | 2.9e-03 |
| active ulcerative colitis | -1.330 | 3.7e-03 |
| adult high grade glioma | -1.300 | 4.2e-04 |
| Breast cancer | 1.400 | 1.8e-14 |
| colon cancer | 1.300 | 5.0e-02 |
| intraductal papillary-mucinous neoplasm ... | 1.200 | 1.5e-03 |
| malignant mesothelioma | 1.500 | 1.1e-05 |
| medulloblastoma, large-cell | -1.100 | 6.1e-04 |
| osteosarcoma | -3.652 | 2.1e-10 |
| ovarian cancer | 1.400 | 7.9e-07 |
| psoriasis | 1.600 | 5.0e-04 |
| sonic hedgehog group medulloblastoma | 1.100 | 3.8e-04 |
| tuberculosis | 1.300 | 7.8e-07 |
CHEMBL388501
pKi 6.28
CHEMBL390990
pKi 6.55
CHEMBL3409336
pIC50 6.61
CHEMBL3628344
pIC50 6.71
CHEMBL3628346
pIC50 6.72
CHEMBL3409334
pIC50 6.94
CHEMBL1834488
pIC50 7.00
CHEMBL3407519
pIC50 7.22
CHEMBL3628345
pIC50 7.27
CHEMBL3409335
pIC50 7.42
CHEMBL34259
pIC50 7.92
CHEMBL225071
pIC50 8.20
MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNEITP 1 - 70 VLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQLMELFYSVTMAARIAYSSYI 71 - 140 FSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSL 141 - 210 FFNRDDRGRCETSASELERMNPGPGGKLGHALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAG 211 - 280 YYLVVYYVHILWNEVDPTTNSARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLV 281 - 350 FLLAHTRHPSSIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSD 351 - 420 VRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKAAQALSVQDKG 421 - 490 LGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPVTTPSPCTLCSAQASGPEAAD 491 - 560 ETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ 561 - 591 //
