| Tbio | Monocarboxylate transporter 5 |
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 1.0e-17 |
| ependymoma | 4679 | 1.3e-14 |
| non-small cell lung cancer | 2890 | 3.9e-11 |
| group 4 medulloblastoma | 1855 | 3.2e-09 |
| ovarian cancer | 8520 | 4.0e-09 |
| astrocytoma | 1146 | 6.4e-09 |
| malignant mesothelioma | 3232 | 3.4e-07 |
| pituitary cancer | 1972 | 4.2e-07 |
| Breast cancer | 3578 | 2.1e-06 |
| Astrocytoma, Pilocytic | 3081 | 3.3e-06 |
| glioblastoma | 5792 | 1.4e-04 |
| adult high grade glioma | 3801 | 2.7e-04 |
| pancreatic cancer | 2398 | 1.2e-03 |
| interstitial cystitis | 2312 | 2.8e-03 |
| active Crohn's disease | 922 | 1.3e-02 |
| active ulcerative colitis | 764 | 1.7e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Pseudomyxoma peritonei | 6 | 3.694 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | 1.366 | 1.3e-02 |
| active ulcerative colitis | 2.209 | 1.7e-02 |
| adult high grade glioma | 2.100 | 2.7e-04 |
| astrocytoma | 1.100 | 6.4e-09 |
| Astrocytoma, Pilocytic | 2.000 | 3.3e-06 |
| Breast cancer | -1.900 | 2.1e-06 |
| ependymoma | 3.100 | 1.3e-14 |
| glioblastoma | 1.800 | 1.4e-04 |
| group 4 medulloblastoma | 3.100 | 3.2e-09 |
| interstitial cystitis | 1.400 | 2.8e-03 |
| lung carcinoma | -1.800 | 1.0e-17 |
| malignant mesothelioma | -1.700 | 3.4e-07 |
| non-small cell lung cancer | -1.696 | 3.9e-11 |
| ovarian cancer | -1.900 | 4.0e-09 |
| pancreatic cancer | 1.400 | 1.2e-03 |
| pituitary cancer | -1.100 | 4.2e-07 |
MLKREGKVQPYTKTLDGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIGWIGSIMSSLR 1 - 70 FCAGPLVAIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAFLYQVAAVVTTKYF 71 - 140 KKRLALSTAIARSGMGLTFLLAPFTKFLIDLYDWTGALILFGAIALNLVPSSMLLRPIHIKSENNSGIKD 141 - 210 KGSSLSAHGPEAHATETHCHETEESTIKDSTTQKAGLPSKNLTVSQNQSEEFYNGPNRNRLLLKSDEESD 211 - 280 KVISWSCKQLFDISLFRNPFFYIFTWSFLLSQLAYFIPTFHLVARAKTLGIDIMDASYLVSVAGILETVS 281 - 350 QIISGWVADQNWIKKYHYHKSYLILCGITNLLAPLATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRN 351 - 420 STVNRFLGLASFFAGMAVLSGPPIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFVPLAERWKNSLT 421 - 487 //
