SLC14A2
Urea transporter 2
Protein Summary
Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
- ENST00000255226
- ENSP00000255226
- ENSG00000132874
- ENST00000586448
- ENSP00000465953
- ENST00000642891
- ENSP00000494834
- ENSG00000285096
- ENST00000643366
- ENSP00000494573
- HUT2
- UT2
- UT2
- UTA
- UTR
- HUT2
- UT-A2
- hUT-A6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
phenotype | 0.74 | ||
cell type or tissue | 0.73 | ||
co-expressed gene | 0.65 | ||
disease | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.87 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 67 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.87 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 67 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0