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Tchem
SLC12A5
Solute carrier family 12 member 5

Protein Summary
Description
Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262). K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript v ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243964
  • ENSP00000243964
  • ENSG00000124140
  • ENST00000454036
  • ENSP00000387694

Symbol
  • KCC2
  • KIAA1176
  • KCC2
  • EIG14
  • hKCC2
  • EIEE34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.7
small molecule perturbation
0.62
gene perturbation
0.6
molecular function
0.6
microRNA
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 760.53   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 311   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 760.53   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 311   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0