SIM1
Single-minded homolog 1
Protein Summary
Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or cognitive disability of Down syndrome. [provided by RefSeq, Jul 2008]
- ENST00000262901
- ENSP00000262901
- ENSG00000112246
- ENST00000369208
- ENSP00000358210
- BHLHE14
- bHLHe14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
gene perturbation | 0.8 | ||
PubMedID | 0.6 | ||
phenotype | 0.56 | ||
disease | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 262.02 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 153 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 262.02 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 153 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0