Tbio SHC4 SHC-transforming protein 4

Protein Summary

Description

Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.

Uniprot Accession IDs

• Q6S5L8
• Q6UXQ3
• Q8IYW3

Gene Name

• SHC4

Ensembl ID

• ENST00000332408
• ENSP00000329668
• ENSG00000185634
• ENST00000396535
• ENSP00000379786

Symbol

• SHCD
• RaLP
• SHCD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.86
virus perturbation	0.83
histone modification site profile	0.77
protein domain	0.73
hub protein	0.67

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Shc-transforming Protein 4

DTO Classes

Protein / Signaling / Shc-transforming Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.34   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.34   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0