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Tbio SH2 domain-containing protein 3A

May play a role in JNK activation.

 Comments

Property Summary

NCBI Gene PubMed Count 9
PubMed Score 291.41
PubTator Score 204.80

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count P-value
osteosarcoma 7950 3.5e-06
ovarian cancer 8520 3.9e-06
pancreatic cancer 2398 1.4e-04
colon cancer 1478 9.7e-03
interstitial cystitis 2312 1.2e-02
spina bifida 1074 2.7e-02
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8

Expression

  Differential Expression (6)

Disease log2 FC p
colon cancer 1.200 9.7e-03
interstitial cystitis -1.100 1.2e-02
osteosarcoma -1.396 3.5e-06
ovarian cancer -1.200 3.9e-06
pancreatic cancer 1.100 1.4e-04
spina bifida -1.401 2.7e-02

Synonym

Accession Q9BRG2 A8K9R6 B4DRS7 Q9Y2X4
Symbols NSP1

Gene

SH2D3A

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (6)

 GO Function (2)

 GO Component (1)

 GO Process (2)

 Compartment GO Term (11)

 HCA RNA Cell Line (56)

See all...

Gene RIF (2)

AA Sequence 

MQVPQDGEDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALRPR      1 - 70
PGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGPLRRSFSEDTLMDGPARIEPLR     71 - 140
ARKWSNSQPADLAHMGRSREDPAGMEASTMPISALPRTSSDPVLLKAPAPLGTVADSLRASDGQLQAKAP    141 - 210
TKPPRTPSFELPDASERPPTYCELVPRVPSVQGTSPSQSCPEPEAPWWEAEEDEEEENRCFTRPQAEISF    211 - 280
CPHDAPSCLLGPQNRPLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLEL    281 - 350
LTLPHGHHLRLELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAAVMGAL    351 - 420
LMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVAPMVRLLEGEEVAGPL    421 - 490
DESCERLLRTLHGARHMVRDAPKFRKVAAQRLRGFRPNPELREALTTGFVRRLLWGSRGAGAPRAERFEK    491 - 560
FQRVLGVLSQRLEPDR                                                          561 - 576
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Text Mined References (15)

PMID Year Title